THE CENTRAL NERVOUS SYSTEM IN MORPHINISM

JEAN M. SWAINAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 102, Number 3

https://doi.org/10.1176/ajp.102.3.378

Get Access

Abstract

1. A brief review of the literature concerning the central nervous system involvement in morphinism is presented. Although there are scattered clinical and pathological reports which indicate that acute and chronic residuals may result, no consistent picture of the neurological involvement can be formulated.

2. Histopathological studies are reported in three cases of morphinism in which the illness varied in duration from the very acute to the chronic stage.

3. Definite histological alterations were present within the brains of all cases and consisted of acute or chronic neuronal alteration and destruction and irregular penvascular demyelinization. The damage was similar in all cases but was more apparent in the chronic ones. The most severe nerve cell changes were observed in the medulla.

4. There is good experimental evidence to suggest that morphine at certain doses may be a cortical stimulant and is probably contraindicated in toxic conditions resulting in convulsive phenomena.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 102 • Number 3 • November 1945

Pages: 378 - 384

PubMed: 21007688

History

Published in print: November 1945

Published online: 1 April 2006

Authors

Affiliations

JEAN M. SWAIN

The Department of Neuropsychiatry, University of Minnesota.

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

There are no citations for this item

View Options

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

THE CENTRAL NERVOUS SYSTEM IN MORPHINISM

Abstract

Get full access to this article