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Published Online: May 1953

NEUROPATHOLOGIC LESIONS FOLLOWING LOBOTOMY : A Study of Fifteen Cases of Bilateral Prefrontal Lobotomy

NAOMI RASKIN, GEORGE STRASSMAN, and CHARLOTTE C. VAN WINKLEAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 109, Number 11

https://doi.org/10.1176/ajp.109.11.808

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Abstract

The objectives of this survey were the study of the brain changes following lobotomy and the influence of infection, toxins, systemic disease, etc., on the course of healing of the wound. The findings in the cases of long and short survival are compared and evaluated.

1 The brain wound is larger than the original incision in all cases.

2. The process of repair in an aseptic wound is slow and when completed results in cystic necrotic formations in the white matter of frontal lobes.

3. The cortical wound heals faster than the subcortical.

4. The meninges are thickened and there are often adhesions between the dura, leptomeninges, and the cortical wound.

5. The process of repair may be greatly retarded by bacterial infections, toxins, focal and systemic infection, nephritis, etc., preceding or following lobotomy.

6. Because of technical difficulties, more tissue is destroyed than the rationale of this treatment warrants.

7. The clinical expression of this added destruction may account for many symptoms beclouding the release of tension and anxiety achieved by sectioning of the thalamofrontal fibers.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 109 • Number 11 • May 1953

Pages: 808 - 816-5

PubMed: 13050800

History

Published in print: May 1953

Published online: 1 April 2006

Authors

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NAOMI RASKIN

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GEORGE STRASSMAN

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CHARLOTTE C. VAN WINKLE

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The Pathological Laboratories of the Boston State Hospital, Boston, Mass.

Metropolitan State Hospital, Waltham, Mass.

Taunton State Hospital, Taunton, Mass.

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NEUROPATHOLOGIC LESIONS FOLLOWING LOBOTOMY : A Study of Fifteen Cases of Bilateral Prefrontal Lobotomy

Abstract

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