APPLICATION OF AN OBJECTIVE METHOD FOR MEASURING THE ACTION OF "ANTIDEPRESSANT" MEDICATIONS

GORDON W. OLSONAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 118, Number 11

https://doi.org/10.1176/ajp.118.11.1044

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Abstract

Most investigations of "antidepressant" medications have depended on clinical assessment of the symptom. This study undertook to apply an objective measure of depression to determine the effectiveness of nialamide, as representative of monoamine oxidase inhibitors, in a state hospital population.

The results showed that both ward behaviour and depression improved significantly more in a high dosage group than for the low dosage and control groups but at the risk of additional behavioral and physical side effects. It was concluded that the measure of depression employed has merit and that nialamide used watchfully in high doses represents a worthwhile contribution for the treatment of the depressed or apathetic patient.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 118 • Number 11 • May 1962

Pages: 1044 - 1045

PubMed: 14481934

History

Published in print: May 1962

Published online: 1 April 2006

Authors

Details

GORDON W. OLSON

Anoka State Hospital, Anoka, Minn.

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APPLICATION OF AN OBJECTIVE METHOD FOR MEASURING THE ACTION OF "ANTIDEPRESSANT" MEDICATIONS

Abstract

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