OBSERVATIONS ON PHENOTHIAZINE CONCENTRATES AND DILUTING AGENTS

P. GORDON LEVER and J. ROSS HAGUEAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 120, Number 10

https://doi.org/10.1176/ajp.120.10.1000

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Abstract

When phenothiazine concentrates are administered with the diluting agents recommended by the manufacturers, precipitates may be formed which are sometimes colored. These render the mixture unpalatable and the patient may not ingest the full amount of the phenothiazine prescribed. It is possible that some of the compounds formed are reverted to their original form by the gastric acidity. However, some do appear to be permanently insoluble.

As a result of these studies, it appears that, ideally, the phenothiazine concentrates should be given diluted with freshly distilled water only. When this method of administration was tried on two wards, patient acceptance was varied and was dependent upon the taste of the vehicle and the total amount of phenothiazine involved.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 120 • Number 10 • April 1964

Pages: 1000 - 1002

PubMed: 14138826

History

Published in print: April 1964

Published online: 1 April 2006

Authors

Affiliations

P. GORDON LEVER

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J. ROSS HAGUE

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Chief, Psychiatric Serv., Instructor in Psychiatry, Univ. Miami.

Senior Psychiatrist, South Florida State Hosp., Hollywood, Fla.

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OBSERVATIONS ON PHENOTHIAZINE CONCENTRATES AND DILUTING AGENTS

Abstract

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