Metronidazole in the Treatment of Alcoholism: A Negative Report

DONALD W. GOODWINAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 123, Number 10

https://doi.org/10.1176/ajp.123.10.1276

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Abstract

The present study was an attempt to confirm Taylor's observations that metronidazole reduces the desire of alcoholics to drink and produces disulfiram-like reactions to alcohol. Neither observation was confirmed.

Of 12 "good prognosis" alcoholics receiving metronidazole as outpatients, eight resumed heavy drinking within six weeks. Two of the remaining four patients stopped the drug because of apparent side effects and the other two, although abstinent on the drug for four months, remained sober on placebo and were unable to distinguish drug from placebo.

Disulfiram-like reactions, when reported, were equivocal and in one patient persisted on placebo.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 123 • Number 10 • April 1967

Pages: 1276 - 1278

PubMed: 6021697

History

Published in print: April 1967

Published online: 1 April 2006

Authors

Affiliations

DONALD W. GOODWIN

Department of Psychiatry, Washington University School of Medicine, Barnes and Renard Hospitals, 4940 Audubon Avenue, St. Louis, Mo. 63110

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Metronidazole in the Treatment of Alcoholism: A Negative Report

Abstract

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