Critique of Studies of Lithium Salts in the Treatment of Mania

WILLIE KAI SHULL and JOSEPH D. SAPIRAAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 127, Number 2

https://doi.org/10.1176/ajp.127.2.218

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Abstract

The authors review all available studies of lithium therapy of mania (comprising 805 patients) to determine whether lithium's pharmacologic efficacy has been demonstrated in the customary manner. All studies reviewed except for one were found to have serious methodological deficiencies. The authors conclude that the available data demonstrate neither efficacy nor inefficacy, primarily because of inadequate experimental design.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 127 • Number 2 • August 1970

Pages: 218 - 222

PubMed: 4919638

History

Published in print: August 1970

Published online: 1 April 2006

Authors

Affiliations

WILLIE KAI SHULL

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JOSEPH D. SAPIRA

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Intern at St. Vincent's Hospital and Medical Center of New York, 153 W. 11th St., New York, N. Y. 10011

Assistant professor of medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa.

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Critique of Studies of Lithium Salts in the Treatment of Mania

Abstract

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