S-adenosylmethionine and Catechol-O-methyltransferase in Schizophrenia

STEVEN MATTHYSSE and ROSS J. BALDESSARINIAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 128, Number 10

https://doi.org/10.1176/ajp.128.10.1310

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Abstract

The authors examined the hypothesis of disordered transmethylation in schizophrenia by comparing S-adenosylmethionine (SAMe) concentration and cathechol-O-methyltransferase (COMT) activities in venous blood of schizophrenic and nonschizophrenic patients. While they did not find a difference in blood SAMe concentration between the groups, they did find a significant correlation between blood COMT activity and SAMe concentration. This suggests that some schizophrenics may methylate biogenic amines more actively than others.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 128 • Number 10 • April 1972

Pages: 1310 - 1312

PubMed: 5013751

History

Published in print: April 1972

Published online: 1 April 2006

Authors

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STEVEN MATTHYSSE

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ROSS J. BALDESSARINI

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Assistant Professor of Psychobiology, Psychiatric Research Laboratories, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Mass. 02114

Assistant Professor of Psychiatry and Chief of the Neuropsychopharmacology Laboratory, Psychiatric Research Laboratories, Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, Mass. 02114

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S-adenosylmethionine and Catechol-O-methyltransferase in Schizophrenia

Abstract

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