Page numbers printed in boldface type refer to tables or figures.
Ablative surgery,365–366
Absence seizures,151
Acalculia,115
Acamprosate,279,
280, 281
Acetylcholine,25,
26, 145
Achromatopsia,120, 122
Acquired demyelination,251
Acquired hepatocerebral degeneration,217Acquired stuttering,113
Acute adrenocortical insufficiency,308–309, 310
Acute dystonia,229Addiction, neurobiology of,274–275
Addison’s disease,308
Adenosine receptor antagonists,208Adrenocortical insufficiency,308–309, 310, 312
Aducanumab,189Affect, and depression or mania,42, 44.
See also Emotions; Mood
Age, and stroke,233,
237–
238.
See also Children; Older adults
Age of onset, of PD,205
Aggressiondifferential diagnosis of,63–64
TBI and,269
Agitation, and dementia,190, 201–202
Agnosias,124–127
Agranulocytosis,345, 346
Agraphia,108–109, 168
AIDS, and progressive multifocal leukoencephalopathy,260
See also HIV
Akathisia,229, 344
Akinesia,229, 344
Akinetic mutism,96
Alcohol use disorder (AUD), and alcoholism,144, 273–274, 279,
280, 281.
See also Substance abuse
Alcohol Use Disorders Identification Test (AUDIT),275–276
Alexias,108–109
Alice in Wonderland syndrome,53
Alternative psychosis,159–160
Alzheimer’s diseaseantipsychotics and,347
brain imaging and,187dementia and,181, 183–185, 188,
189pathological and neurochemical changes in,186treatment of,189Amantadine,208, 209, 258
Ambulatory monitoring, and electroencephalography,15
American Academy of Neurology,157, 211
American Epilepsy Society,158
Amnesia,144, 145–146.
See also Anterograde amnesia; Dissociative amnesia; Posttraumatic amnesia; Psychogenic amnesias; Retrograde amnesia; Transient global amnesia
Amoxapine,161
Amusia,110,
136Amygdalaaddiction and,275
ASD and,288
essential neuroanatomy and,26,
27memory and,144
Amyloid PET, and dementia,178, 180
Amyloid plaques, and Alzheimer’s disease,185
Angelman syndrome,47
Angular gyrus syndrome,116
Anomic aphasia,106, 107, 168
Anosodiaphoria,130
Anosognosia,7,
50, 129–130,
136Anoxia,144Anterior capsulotomy,366
Anterior cingulate cortex (ACC),248, 366–367
Anterior temporal lobectomy, and epilepsy,162,
163Anterograde amnesia,37, 143
Anticholinergics, and PD,208, 209
Anticoagulation therapy, and stroke,238
Anticonvulsant(s)clinical applications of,350,
351–
354drug–drug interactions and,356electroencephalography and,13
pharmacokinetics of,355–357
psychiatric risk of in patients with epilepsy,160,
161Anticonvulsant-induced chorea,217Antidepressants.
See also Monoamine oxidase inhibitors; Selective serotonin reuptake inhibitors; Tetracyclic antidepressants; Tricyclic antidepressants; Unicyclic antidepressants
ASD and,294
drug interactions and,343
novel forms of,341–342
for psychiatric symptoms in epilepsy patients,158–159, 161
serotonin augmenting agents and,340–341
side effects of,342,
343Anti-LG11 encephalitis,320–321
Anti-NMDA receptor encephalitis,227, 320
Antipholipid antibody syndrome,217Antipsychotics.
See also Neuroleptic-induced movement disorders
ASD and,293–294
Huntington’s disease and,218
indications for,347
older patients with dementia and,241–242
parkinsonism and,215
PD and,212
pharmacokinetics of,344
side effects of,344,
345, 346–347
tic syndromes and,222
typical and atypical forms of,343–344
Anton’s syndrome,50, 123
Anxiety, and anxiety disorders ASD and,290
differential diagnosis of,53–55
epilepsy and,155, 159
hypothyroidism and,303
left-brain lesions and,137multiple sclerosis and,257
PD and,210
stroke and,239, 240
Apathydementia and,190, 202
frontal-subcortical circuits and,30medial frontal syndrome and,95–96
PD and,210–211
personality change and,59,
60stroke and,239, 241
TBI and,269
Apathy Evaluation Scale,241
Aphasia,105–108,
137, 184.
See also Transcortical aphasia
Aphemia,112Apperceptive visual agnosia,126
Applied behavior analysis (ABA),292
Apractic agraphia,109
Apraxia,113–115, 130,
137Aprosodia,94, 109–110
Arcuate fasciculus,31, 33
Aripiprazole,345Arteriovenous malformations,237Ashton Manual,278
Asomatagnosia,50Assessment.
See also Diagnosis; Screening
aphasias and,108
of ASD,288,
289brain imaging and,15–21
of cerebrovascular disease,236
of dementia,178–180
electroencephalography and,12–15
of FNSD,70–71, 75, 77
frontal lobe syndromes and,87–
89, 90–97
initial observations and,2–4
of mutism,111
neurological examination and,8,
9–
10neuropsychological testing and,4–8
of TBI,267
Associative visual agnosia,126–127
Asymptomatic neurocognitive impairment (ANI),324,
325Ataxia,222–224
Ataxic dysarthrias,111
Atherothrombotic occlusion,234,
235Attention.
See also Cognitive impairment
assessment and span of,6
delirium and,168
dorsolateral prefrontal syndrome and,93–94
Attention-deficit/hyperactivity disorder (ADHD),294
Atypical parkinsonism,213–215
Auditory hallucinations,53, 241
Auditory neglect,128
Autism spectrum disorder (ASD),285–295
Autistic-like traits,287
Autoimmune disorders,46,
252, 259
Automatisms, and epilepsy,151
Autonomic disturbances, and anxiety,54
Autosomal dominant ataxia, and autosomal recessive ataxia,223Babinski sign,94
Balance difficulties, and TBI,270
Balint’s syndrome,120, 123
Baltic myoclonus,153
Barbiturates,347
Basal ganglia,29–30, 205, 207, 274–275
Bear-Fedio Inventory,157
Beck Depressive Inventory,255
Bedside mental state testing,5–
6Behavior.
See also Aggression; Agitation; Apathy; Disinhibition; Irritability; Repetitive behaviors; Schizoid behavior; Self-injurious behavior; Sexual behavior; Social behavior
brain regions and,37–39
Huntington’s disease and,216
stroke and,239TBI and,268–269
Behavioral neurology, and brain-behavior relationships,37–39.
See also Assessment; Diagnosis; Interventional psychiatry; Neuroanatomy; Neuropsychiatric disorders; Treatment;
specific disordersBehavioral therapy, for TBI,267
Behavioral variant frontotemporal dementia (bvFTD),192
Bells Test,127–128
Benign epilepsy with centrotemporal spikes,152
Benign familial chorea,217Benzodiazepines,227, 257, 276–278, 348, 349
Beta-blockers,307
Binswanger disease,261
Bipolar depression,342
Bipolar disorder,158, 240, 256–257, 302.
See also Mania Biopsychological formulation epilepsy and,155
FNSD and,75, 77
Blindness, and visuoperceptual disorders,120–122
Body-spatial disorientation,130–131
Botulinum toxin, and dystonia,220
Bradykinesia, and PD,206
Brain.
See also Brain tumors; Left hemisphere; Neuroanatomy; Right hemisphere
brain-behavior relationships,37–39
depression and disorders of,43,
44evolution and vulnerability of to ischemic injury,233
hemispheric specialization and cerebral dominance,103–105
HIV and,323
network organization of,34, 36
repetitive behaviors and dysfunction of,57–
58Brain imaging.
See also Computed tomography; Electroencephalography; Magnetic resonance imaging; Positron emission tomography
addiction and,274
assessment and,15–21
dementia and,178,
179, 187–188
Brain tumors,245–249.
See also Cerebral tumors
Brief neurological screening examination,9–
10Broca’s aphasia,106, 107
Broca’s area,37
Bromosis,50Buccal-lingual apraxia,114
Buprenorphine,281–282
Bupropion,161, 211, 341
Bush-Francis Catatonia Rating Scale,225
Buspirone,349
Butterfly glioma,245–246
California Encephalitis Project,315
Callosal apraxia,114,
115, 116
Cancer. See Brain tumors; Neoplastic disordersCapgras syndrome,49, 136, 148
Carbamazepine,351, 355
Cardiac side effects, of antipsychotics,345, 346
Cardiopulmonary disease, and delirium,171Cardiovascular symptoms, of hyperthyroidism and hypothyroidism,303, 307
Caregivers, and Alzheimer’s disease,188
Case exampleof delirium,173–174
of limbic encephalitis,316–317
Catatonia,225,
226, 227,
228, 291
Catechol-O-methyltransferase inhibitors,208Center for Epidemiologic Studies Depression Scale,239
Centers for Medicare and Medicaid Services,368
Central nervous system (CNS)metastatic disease and,246
neuropsychiatric syndromes and tumors of,247–248
pharmacotherapy and,336
white-matter disorders and,251
Cerebellum,36, 288
Cerebral cortex, and essential neuroanatomy,31–36
Cerebral dominance,103–105
Cerebral emboli,234,
235Cerebral palsy,217Cerebral surgery, and epilepsy,162,
163Cerebral tumors,146, 163.
See also Brain tumors
Cerebral venous thrombosis,237Cerebrospinal fluid (CSF),180, 185
Cerebrovascular disease-stroke,233–243.
See also Stroke
Charles Bonnet syndrome,50
Chelation therapies,294
Children, and epilepsy,153.
See also Age; Developmental conditions; Developmental delay
Chlordiazepoxide,348Chlorpromazine,345Cholinesterase inhibitors,195
Choreas, differential diagnosis of,217, 218–219
Chronic autoimmune thyroiditis,302, 304
Chronic traumatic encephalopathy (CTE),194, 216
See also Traumatic encephalopathy syndrome
Cingulate gyrus,27, 29
Clobazam,348, 351
Clock-drawing tests,128, 169
Clomipramine,161
Clonazepam,348, 351
Clorazepate,348Clothing, and body-spatial disorientation,130–131
Clozapine,161, 196, 344,
345CNS HIV Anti-Retroviral Therapy Effects Research study,325
Cognitive-behavioral therapy FNSD and,78
multiple sclerosis and,256
substance use disorders and,278
Cognitive impairment.
See also Attention; Cognitive rehabilitation; Memory
anxiety and,53
bedside mental state testing and,5–
6depression and,42
ECT and,364
HIV-associated neurocognitive disorders and,324
Huntington’s disease and,216
hypercortisolemia and,310–311
hyperthyroidism and hypothyroidism,303,
307lateral orbitofrontal syndrome and,95
mania and,44–45
medial frontal syndrome and,96
multiple sclerosis and,257
OCD and,55
PD and,206
TBI and,268
visuospatial disorders and,134–135
Cognitive rehabilitationHIV-related neurocognitive disorders and,329
TBI and,267
Color blindness,120, 122, 124,
125Combination antiretroviral therapy (cART),323, 324, 327–328, 330
Comorbidity, of psychiatric disordersepilepsy and,155
FNSD and,71
multiple sclerosis and,254–259
OCD and,55
Comprehension, of spoken language,105, 107
Compulsivity, and addiction,275
Computed tomography (CT),15, 16,
18–
19, 20, 108
Concussion,265.
See also Poststroke syndrome
Conduction aphasia,106,
115, 116
Confabulation,143, 145
Constructional ability, and assessment,7
Constructional disorders,131–134
Contingent negative variation (CNV),14–15
Continuous performance tasks,93–94
Control, delusions of,50Conversion reaction, and blindness,121
Copying deficits, and constructional disorders,132–133
Copying tasks, and dorsolateral prefrontal syndrome,91
Corpus callosum,31
Cortical blindness,120, 122–123
Corticobasal degeneration (CBD),181, 183,
186,
187, 193–194
Corticobasal syndrome,213–214
Cortisol, and depression,42
Cotard’s syndrome,49Coup contrecoup,265
Creutzfeldt-Jakob disease,198–199
Cursive seizures,151
Cushing’s syndrome,310
Cytochrome P450 system,336–337
Dacrystic seizures,46
Deep brain stimulation (DBS)behavioral neurology and,36, 39
epilepsy and,162, 163
interventional psychiatry and,366–367
PD and,209
Default network, of cerebral cortex,34, 36
Degenerative disorders, and frontal lobes,98Dehydration, and delirium,171Dehydroepiandrosterone (DHEA),309
Deliriumdefinition of,167
dementia and,174diagnosis of,170, 172
HIV/AIDS and,329
hypocortisolemia and,309
mental status examination and,168–169
neurological examination and,169
pathophysiology of,169–170
prevention and treatment of,172–174
types of,167–168
Delusion(s)assessment and,3, 4
differential diagnosis of,48
DLB and,195
right-brain dysfunction and,136
stroke and,241
types of,49–
50Delusional jealousy,49Delusional misidentification syndromes,148
Delusional parasitosis,50Dementia.
See also Alzheimer’s disease; Dementia with Lewy bodies; Frontotemporal dementias; Parkinson’s disease
assessment of,178–180
definition of,177
delirium and,174differential diagnosis of,180–183
ECT for,365treatment of,199, 201–202, 241–242
types of,192–199
Dementia with Lewy bodies (DLB)antipsychotics and,347
brain imaging and,187clinical features of,214–215
differential diagnosis of,182, 183
pathological and neurochemical changes,186, 194–196
Dementia with Lewy Bodies Consortium (2017),214
Demyelinating disorders,98,
200Depersonalization,59, 61–62
Depression.
See also Bipolar depression
ablative surgery for,365–366
ASD and,289–291
brain tumors and,248
DBS and,366–367
dementia and,190, 202
differential diagnosis of,41–44
ECT and,363–364
epilepsy and,155, 157
hypothyroidism and,303, 305
left-brain lesions and,137PD and,210
right-brain dysfunction and,136
stroke and,239–240, 242–243
TMS and,362–363, 364
VNS for,368
Derealization,59, 61–62
Dermatological symptoms, of endocrine disorders,303, 314
Design fluency test,92, 134–135
Deutetrabenazine,218, 222
Developmental conditions, and mutism,112.
See also Neurodevelopmental disorders
Developmental delay, and assessment,8
Dexamethasone suppression test,42, 312
Diagnosis.
See also Assessment; Differential diagnosis
basis of neuropsychiatric,41
of bipolar depression,342
of delirium,170, 172
of FNSD,67
of hypercortisolemia,311–312
of hyperthyroidism,308
of hypocortisolemia,309
of hypothyroidism,304
of limbic encephalitis,317–318
of multiple sclerosis,252,
253of substance use disorder,275–278
Diaschisis, and brain network functions,36, 39
Diazepam,348Diet, and monoamine oxidase inhibitors,338
Differential diagnosis.
See also Assessment; Diagnosis
of aggressive behavior,63–64
of altered sexual behavior and paraphilic disorders,62–63
of anxiety,53–55
of brain tumors,247of catatonia,228of chorea,217of delusions,48
of dementia,180–183
of depression,41–44
of dissociative disorders,59, 61–62
of FNSD,70–71, 75, 77
of hallucinations and illusions,48–53
of HIV neurocognitive disorders,328, 329–330
of limbic encephalitis,318–319
of mania,44–45
of mood and affect lability,45–47
of mutism,112of OCD,55–59
of personality change,59,
60–
61of psychosis,47–48
Diffusion weighted imaging (DWI),17
Digit span test,93–94
Direct electrical stimulation, of neural tissue,37–39
Disability, and FNSD,79
Disconnection syndromes,116
Discontinuation syndrome, and tricyclic antidepressants,340
Disinhibitiondementia and,190, 192
frontal-subcortical circuits and,30lateral orbitofrontal syndrome and,95
personality change in neurological disorders,60Dissociative amnesia,59, 147
Dissociative disorders, differential diagnosis of,61–62, 69
Disulfiram,280, 281
Donepezil,189Dopamine, clinical relevance of,25,
26.
See also Dopamine receptors Dopamine agonists,
208, 212–213
Dopamine receptors, and antipsychotics,344
Dorsolateral prefrontal syndrome,60,
87–
88, 90–94
Drawing abnormalities,132, 133–134
Dressing disturbances,130–131,
136Drug-induced parkinsonism,215
DSM-5, and criteria forASD,285,
286delirium,170
FNSD,67
major depressive episodes,41–42
manic episodes,45
psychiatric disorders comorbid with epilepsy,155
PTSD,54
somatic symptom disorder,67
substance use disorder,276,
277Dysarthria,110–111
Dysmnesic states,148
Dysmyelination,251
Dysphagia,111
Dystonic disorders,219–220
Dystonic dysarthrias,111
Echolalia,113
Edentulous dyskinesia,217Education, on TBI,267
Electroconvulsive therapy (ECT)ASD and,295
catatonia and,227
interventional psychiatry and,363–364,
365multiple sclerosis and,256
for patients with epilepsy,161
for patients with post-stroke depression,242–243
Electroencephalography (EEG)assessment and,12–15
delirium and,170, 172
limbic encephalitis and,317–318
Emotions.
See also Affect; Mood anxiety and,53
right-brain dysfunction and,137
TBI and,268
Encephalitis. See also Anti-LG11 encephalitis; Anti-NMDA receptor encephalitis; Herpes simplex encephalitis; Limbic encephalitis; NMDA receptor encephalitismemory disorders and,146
temporal lobe disorders and,163–164
Endocannabinoid,25Endocrine disorders, and depression,42.
See also Hypercortisolemia; Hyperthyroidism; Hypocortisolemia; Hypothyroidism
Environmental agnosia,120, 124,
125Environmental dependence, and dorsolateral prefrontal syndrome,94
Environmental recognition,136Epidemiologyof alcohol use disorder,273–274
of ASD,285–286
of epilepsy,151, 155
of FNSD,68
of PD,205
Epilepsia partialis continua,152
Epilepsy. See also Temporal lobe epilepsyaffect abnormalities and,46–47
description of syndromes,151–154
ECT for,365electroencephalography and,14
epidemiology of,151, 155
FNSD and,69, 71
memory and,144psychiatric disorders and,154–160
TBI and,271
treatment of,161–163
Episodic ataxia,223Erotomanic (de Clerambault syndrome) delusions,49Esketamine,342
Estrogen, and hyperthyroidism,306
Ethosuximide,351European AIDS Clinical Society (EACS),325, 326–327
Evoked potentials, and electroencephalography,14–15
Executive aprosodia,136Executive functionassessment and,7
dorsolateral prefrontal syndrome and,90
frontal-subcortical circuits and,30Executive prosody,109–110
Expressive aphasia,94
Expressive language,7
Extended amygdala,29
Extrapyramidal reactions (EPRs), and antipsychotics,344,
345, 347
Eyes, and hyperthyroidism,307.
See also Visual hallucinations
Facial discrimination defects,136Facial recognition, and prosopagnosia,125–126
Family history, and assessment,7
Fatiguemultiple sclerosis and,257–258
PD and,211
Felbamate,352Finger agnosia,116, 125
Flaccid dysarthrias,110
Fluent aphasias,105
Fluid-attenuated inversion recovery (FLAIR),17
Flumazenil,349
Fluorodeoxyglucose (FDG) PET imaging, and dementia,178
Fluoxetine,159
Flurazepam,348Focal seizures,151,
152, 153
Folie á deux,49Food and Drug Administration (FDA),279
Forced normalization,159–160
4-Aminopyridine,224
Fregoli syndrome,49, 148
Freud, Sigmund,69
Frontal alexia,108
Frontal cortex,288
Frontal lobe(s). See also Frontal lobe syndromesassessment and,7
diseases of,97–100
dysfunction associated with white matter injury,97
memory function and,144–145
neuroanatomy and,31, 33, 85–86
tumors of,248
Frontal lobe syndromes,86,
87–
89, 97, 99–100.
See also Dorsolateral prefrontal syndrome; Lateral orbitofrontal syndrome; Medical frontal syndrome
Frontal-subcortical circuits, and emotional behavior,30Frontotemporal dementias (FTDs),55,
181, 183,
186,
187, 192–194
Fugues,59, 147
Functional-anatomical networks, and cerebral cortex,34,
35Functional behavior analysis,292
Functional magnetic resonance imaging (fMRI),34, 162
Functional neurological symptoms disorder (FNSD),67–79
GABA, clinical relevance of,25, 26
GABA agonists,349
Gabapentin,353, 355
Gait. See also Motor symptomsFNSD and,75, 78
frontal white matter and,97
Galantamine,189Ganser syndrome,147, 148
Gastaut syndrome,152, 153, 156–157
Gastrointestinal disturbancesdelirium and,171hyperthyroidism and hypothyroidism,303, 307
Gaze deviation, and dorsolateral prefrontal syndrome,94
Gelastic seizures,46, 151
Generalized Anxiety Disorder–7,159
Generalized seizures,151,
152,
153Genetic syndromesaggressive behavior and,64
ataxia and,223ASD and,286–287
dementia and,200epilepsy and,154white matter diseases and,252Genetic testing, and dementia,178Gerstmann syndrome,115–116, 125
Geste antagoniste,219–220
Glasgow Coma Scale (GCS),265,
266Glial cells, and composition of brain,23–24
Gliomas,245, 246
Global aphasia,106, 107
Globoid cell leukodystrophy (Krabbe disease),261
Glucocorticoids,310
Glutamate, clinical relevance of,25Goal management training (GMT),97, 99
Go-no go test,91, 96
Gradient echo sequence, and magnetic resonance imaging,17
Gramophone syndrome,113
Grandiose delusions,49Graves’ disease,306
Gustatory hallucinations,53
Hallucinations. See also Visual hallucinationsassessment and,3–4
definition of,48
differential diagnosis of,48–53
DLB and,214
stroke and,241
visuoperceptual disorders and,122
Haloperidol,294,
345Hamartomas,163
Hamilton Rating Scale for Depression,239, 256, 368
Handedness, and cerebral dominance,104–105
Hashimoto’s thyroiditis,302, 304, 305
Headaches. See also Migrainesbrain tumors and,247
TBI and,270
Head injury. See Traumatic brain injuryHeautoscopy (autoscopy),49Hematological disorders, and stroke,237Hemialexia,108
Hemispatial neglect, and visuospatial attention,127
Hemispheric specialization,103–105.
See also Left hemisphere; Right hemisphere
Hemorrhagic strokes,234,
235Hepatic enzymes, and anticonvulsants,356Herpes simplex (HSV-1) encephalitis,144, 318–319
Hippocampus,26,
27, 144, 146
HIV, effects of on brain,323.
See also AIDS
HIV-associated dementia (HAD),324,
325HIV-associated neurocognitive disorders (HANDs),324–329
HIV Dementia Scale,325
Homonymous hemianopsia,120, 122
Hooper Visual Organization Test,134
Hormones, and pituitary damage,270.
See also Endocrine disorders
Hospital(s), and hospitalization catatonia and,227
prevalence of delirium in,167
Hospital Elder Life Program,172
Huntington’s disease,216–218
Hydrocephalus, and dementia,200Hydrocortisone,310
Hyperactive type, of delirium,167–168
Hypercortisolemia,310–312
Hyperesthesia,4
Hyperkalemia, and delirium,171Hyperkinetic dysarthrias,111
Hypernatremia, and delirium,171Hypersexuality,62, 137
Hypertension, and cerebrovascular disease,234
Hyperthyroidism,171,
217, 306–308
Hypocortisolemia,308–310
Hypomania,45,
46Hypomyelination,251
Hypnosis, and FNSD,71
Hypoactive type, of delirium,167–168
Hypoglycemia,144, 171
Hypokinetic dysarthrias,111
Hyposexuality,62,
136, 137
Hypothalamus,27Hypothyroidism,171, 301–305
Hypsarrhythmia,153–154
Hysterical dementia,148
Ictal aggression,64
Ictal hallucinations,50
Ictal syndrome,156
Ideational apraxia,115
Ideomotor apraxias,114,
115Illusions. See HallucinationsImmune disorders, and epilepsy,154
See also Autoimmune disorders; HIV; Immunosuppression; Immunotherapy
Immune reconstitutioninflammatory syndrome,329
Immunosuppressionlimbic encephalitis and,320
progressive multifocal leukoencephalopathy and,260
Immunotherapy, for multiple sclerosis,254.
See also Combination antiretroviral therapy
Impulse-control disorders, and PD,212
Impulsivity, and addiction,275
Incubus syndrome,49Infectious disorders. See also Encephalitisdementia and,199,
200epilepsy and,154, 163
frontal lobes and,99mania or hypomania and,46stroke and,237white matter diseases and,252Inflammatory disordersdementia and,199,
200depression and,43
epilepsy and,157
frontal lobes and,99myoclonus and,225white matter diseases and,252Instrumental Activities of Daily Living (IADL) Scale,326–327
Integrase strand transfer inhibitors,327–328
Interictal syndrome,156
Intermetamorphosis,49International HIV Dementia Scale,325
International League Against Epilepsy (ILAE),75, 151–152, 154, 316, 355
Interventional psychiatry, approaches to and modalities of,361–362.
See also Ablative surgery; Deep brain stimulation; Electroconvulsive therapy; Theta burst stimulation; Transcranial magnetic stimulation; Vagus nerve stimulation
Intracerebral hemorrhage,234,
235Involuntary emotional expression disorder,45
IrritabilityHuntington’s disease and,216
personality change in neurological disorders and,60TBI and,268
Ischemic strokes,234,
235I WATCH DEATH mnemonic,172,
173Janz syndrome,153
John Cunningham (JC) virus,260
Juvenile myoclonic epilepsy,153
Kernicterus,217Ketamine,341–342
Kleine-Levin syndrome,60, 62
Klüver-Bucy syndrome,60, 62,
63, 163
Koro,50Korsakoff’s syndrome,145
Laboratory testsassessment of neuropsychological function and,8,
10delirium and,170
dementia and,178,
179multiple sclerosis and,253Lacosamide,353Lafora disease,153
Lamotrigine,353, 355
Language. See also Aphasia; Mutism; Speechassessment and,7
Broca’s area of brain and,37
comprehension of,105, 107
left-brain lesions and,137right-hemisphere injuries and,135
Lateralization, and brain-behavior relationships,37
Lateral orbitofrontal syndrome,95
Learning, and dorsolateral prefrontal syndrome,90
Left hemisphere, of brain,104,
137, 240
Left spatial neglect,136Lennox-Gastaut syndrome,154
Letter fluency task,96
Leukoaraiosis,260–261
Leukodystrophies,261
Levetiracetam,188, 320,
353, 356
Levodopa,207,
208, 217
Lifestyle, and Alzheimer’s disease,188
Limbic encephalitis (LE),315–321
Limbic leucotomy,366
Limbic system, and neuroanatomy,24, 26–29
Limb-kinetic apraxia,114
Line bisection test, for visual neglect,127
Linguistic agraphias,108
Lithium,302, 349–350
Localization, and brain-behavior relationships,37
Locked-in syndrome,96
Locus coeruleus,27Logoclonia,113
Long-term memory,141,
142, 144
Lorazepam,227, 349
Lumbar puncture,12, 180
Lurasidone,345Lycanthropy,49Magnetic resonance imaging (MRI). See also Functional magnetic resonance imagingaphasia and,108
assessment and,15, 17,
18–
19, 20
Magnetoencephalography,15
Major depressive disorder (MDD),248, 254–255
Major neurocognitive disorder,177
Mammillary bodies,27Maniadifferential diagnosis of,44–45
epilepsy and,157
neurological disorders associated with,46right-brain dysfunction and,135–136
stroke and,239, 240
Maprotiline,161
Map reading, and body-spatial disorientation,131
McDonald criteria, and multiple sclerosis,253Mechanical agraphias,109
Medial frontal syndrome,61,
89, 95–96
Medical conditions. See also Cardiopulmonary disease; Cardiovascular symptoms; Cerebrovascular disease-stroke; Gastrointestinal disturbances; Infectious disorders; Neoplastic disordersFNSD and,71
mutism and,112Medulloblastomas,246
Melatonin,294
Memantine,189Memory. See also Amnesia; Cognitive impairmentAlzheimer’s disease and,184
assessment and,7
delirium and,168–169
disorders of in clinical practice,145–146
dorsolateral prefrontal syndrome and,90
dysmnesic states and,148
neuroanatomy of,143–145
systems of,141,
142, 143
tests of function,148,
149visuospatial disorders and,134–135
Meningiomas,245, 246, 248
Mental rotation tests,134
Mental status examination,5–
6, 132, 168–169
Metabolic disordersdelirium and,171dementia and,199,
200epilepsy and,154myoclonus and,225stroke and,237white matter diseases and,252Metachromatic leukodystrophy,261
Methadone,282
Methamphetamine, and HIV,330
Methylphenidate,211
Methylprednisolone,320
Michigan Alcohol Screening Test,276
Migraines,52–53,
237Mild cognitive impairment (MCI),177, 184, 209–210
Mild neurocognitive disorder (MND),324,
325Mild TBI,265
Mineralocorticoid,310
Mini-Mental State Examination,325
Mirror agnosia,49Mirtazapine,341
Misidentification syndromes, and types of delusions,49, 136
Misoplegia,130
Mixed type, of delirium,168
Mnemonics, and delirium,172,
173Moclobemide,338
Modafinil,211, 258
Monoamine oxidase inhibitors,161, 208–209, 337–340
Monocular blindness,120–122
Montreal Cognitive Assessment,325
Mood. See also Affect; Emotions; Mood disordersassessment and,4
depression and changes in,42
lability of,45–47
lateral orbitofrontal syndrome and,95
mania and changes in,44
medial frontal syndrome and,95–96
OCD and changes in,55
Mood disorders. See also Depressionepilepsy and,157–159
neuropsychiatric aspects of,254–256
Mood stabilizers,45, 294.
See also Lithium
Moria,47,
61Mortality, and post-stroke depression with psychosis,241
Motivation, depression and alterations in,42
Motivational counseling, for substance use disorder,278,
279Motor-neglect syndromes,128–129
Motor programming tasks, and dorsolateral prefrontal syndrome,91–93
Motor symptoms. See also Gait; Movement disorders; Tremoranxiety and,53–54
assessment and,2–3
DBS and,366
depression and,42
FNSD and,74mania and,45
Movement disorders. See also Ataxia; Catatonia; Dystonic disorders; Huntington’s disease; Myoclonus; Parkinson’s disease; Parkinsonism; Non-Huntington’s disease choreas; Tic syndromes; Tremorbasal ganglia and,205
limbic encephalitis and,316
mild cognitive impairment and PD dementia,209–210
neuroleptic-induced,228,
229Movement Disorders Society,206
Multiple sclerosis,251–259,
365Multiple system atrophy,182,
186,
188, 196–197, 214
Muscle weakness, and dorsolateral prefrontal syndrome,94
Musculoskeletal symptoms, of hypothyroidism,303Music, and amusia,110
Musical hallucinations,53
Mutism,111,
112Myelin-oligodendrocyte glyprotein (MOG),259
Myoclonic seizures,151
Myoclonus,224–225
N-acetylcysteine,294
Naltrexone,279,
280, 281, 282, 294
Naming, and aphasia,107
Namzaric,189Narcolepsy,53
National Survey on Drug Use and Health (2018),273
Nefazodone,340–341
Neoplastic disorders. See also Brain tumorsamnesia and,144dementia and,201frontal lobes and,98Network organization, of brain,34, 36
Neuroacanthocytosis,217Neuroanatomy. See also Brainaddiction and,275
ASD and,287–288
basal ganglia,29–30
cerebellum,36
cerebral cortex,31–36
FNSD and,70
limbic system,24, 26–29
memory and,143–145
overview of,23–24
reticular activating system,31
visuospatial information,119
Neurodegenerative disorders,185,
186, 225
Neurodevelopmental disorders, and self-injurious behavior,64Neurofibrillary tangles, and Alzheimer’s disease,185
Neuroleptic-induced movement disorders,228,
229Neuroleptic malignant syndrome,345, 346
Neurological disorders. See also Functional neurological symptom disorder; Neurodegenerative disordersaphasias and,107–108
catatonia and,228delirium and,171delusions and,51mania or hypomania,46mood and affective lability,47mutism and,112OCD and,56personality changes and,60–
61visual hallucinations and,52Neurological Disorders Depression Inventory,158
Neurological examinationassessment and,8,
9–
10delirium and,169
FNSD and,71,
74–
75lateral orbitofrontal syndrome and,95
Neuromodulation,36, 162
Neuromyelitis optica (NMO),259
Neurons, and neuroanatomy,23–24
Neuropsychiatric disordersASD and,289–291
brain tumors and,247–248
ECT and,365hypercortisolemia and hypocortisolemia,308–310
multiple sclerosis and,254–259
PD and,210–213
stroke and,238–241
TBI and,268–271
Neuropsychiatry. See Assessment; Behavioral neurology; Diagnosis; Interventional psychiatry; Neuropsychiatric disorders; Treatment; specific disordersNeuropsychological testingdementia and,178
assessment and,4–8,
11visuospatial disorders and,134
Neuroreceptors, and clinical relevance,25Neurostimulation.
See Responsive neurostimulation
Neurosurgery, and mania and,46
See also Ablative surgery
Neurotransmitters. See also Dopamine; Serotonindelirium and,170
epilepsy and,157
essential neuroanatomy and,24, 26
Neurovegetative features, of depression or mania,42, 45
NMDA antagonist. See AmantadineNMDA receptor (NMDAR) encephalitis,315
Nonfluent aphasia,105
Nonfluent variant of primary progressive aphasia (nfPPA),181,
186,
187, 192–193
Non-Huntington’s disease choreas,218–219
Noninvasive stimulation therapies, and FNSD,78–79.
See also Electroconvulsive therapy; Theta burst stimulation; Transcranial magnetic stimulation
Nonnucleoside reverse transcriptase inhibitors,327–328
Nonverbal amnesia,136Norepinephrine, clinical relevance of,25, 26
Normal pressure hydrocephalus,198
Nucleoside/nucleotide reverse transcriptase inhibitors,327–328
Nucleus accumbens,27, 29
Obsessive-compulsive disorder (OCD)ablative surgery for,365–366
ASD and,290
DBS and,366
differential diagnosis of,55–59
rTMS and,99, 363
Olanzapine,161,
345Older adults. See also Ageantipsychotics for,241–242, 347
hypothyroidism and,301
Olfactory hallucinations,53
Oligodendroglias,246
Omega-3 fatty acids,294
Opioid(s), and substance abuse,276, 281–282
Opioid receptor, clinical relevance of,25Optic nerve, and blindness,121–122
Oral contraceptives, and anticonvulsants,356Orbitofrontal syndromes,61,
88, 248
See also Lateral orbitofrontal syndrome
Orthostatic hypotension, and antipsychotics,345Oxazepam,349
Oxcarbazepine,353, 356
Oxytocin,294
Pain, and delirium,171Palilalia,113
Palinopsia,136, 137
Panayiotopoulos syndrome,152, 153
Panic disorder, and epilepsy,155Parahippocampal gyrus,26–27
Paraictal symptoms, and epilepsy,156Parallel distributed processing (PDP),37
Paraphasias,105
Paraphilic disorders,62–63
Parietal apraxia,114,
115Parkinsonism,213,
229.
See also Atypical parkinsonism; Druginduced parkinsonism; Secondary parkinsonism
Parkinson’s disease (PD)antipsychotics and,347
anxiety and,54
brain imaging and,188clinical features of,206–207
DBS and,366
dementia and,182,
186, 196, 209–210
ECT for,365epidemiology of,205
neuropsychiatric disorders and,210–213
pathology of,207
treatment of,207–209
Patient Health Questionnaire (PHQ-9),239, 256
Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS),221
Peduncular hallucinations,52
Peptide, clinical relevance of,25Perampanel,353Perception, and visuospatial processing,119–120
Persecutory delusions,50Personality changedifferential diagnosis of,59,
60–
61epilepsy and,156–157
Pharmacotherapy. See also Anticonvulsants; Antidepressants; Antipsychotics; Mood stabilizers; Sedative-hypnotics; Treatmentfor Alzheimer’s disease,189for ASD,293–294
classification system for psychotropic drugs,338cytochrome P450system and,336–337
for dementia,190–
191, 195–196, 201–202
FNSD and,78
for PD,208, 211–212
stroke induced by,237for substance use disorders,279–282
therapeutic drug monitoring and,335–336
Phenelzine,337
Phenobarbital,352Phenytoin,352, 355
Phosphenes,121
Physical therapy, and FNSD,78
Physiological dependence, and substance use disorder,276–278
Pimavanserin,195, 196, 211, 347
Pituitary ACTH-producing tumors,312
Planning abilities, and dorsolateral prefrontal syndrome,91
Plasma markers, for Alzheimer’s disease,185
Polycythemia vera,217Polysomnography,270
Poriomania,59, 61
Positron emission tomography (PET),15, 20–21, 55
Post-concussive syndrome,271
Postictal symptoms, and epilepsy,64,
156, 160
Posttraumatic amnesia (PTA),141, 143
Posttraumatic parkinsonism,216
Posttraumatic pituitary dysfunction,270
Posttraumatic psychosis,269
Posttraumatic stress disorder (PTSD),54
Precipitating factors. See also Risk factorsfor delirium,170,
171FNSD and,75, 77
Prednisone,310, 312
Prefrontal cortex,33, 275
Pregabalin,353, 355
Preictal symptoms, and epilepsy,156Prevalence. See EpidemiologyPrevention, of delirium,172
Primary acalculia,137Primary brain injury,265
Primary motor cortex,31
Primary progressive form, of multiple sclerosis,254
Primidone,352Prognostic factors, and outcome of FNSD,79
Progressive multifocal leukoencephalopathy (PML),259–260
Progressive myoclonic epilepsy (PME) syndromes,153,
225Progressive supranuclear palsy (PSP),181, 183,
186,
187, 193, 213
Prosody,109
Prosopagnosia,120, 124, 125–126,
136Protease inhibitors,327–328
Protective factors, and Alzheimer’s disease,184
Pseudobulbar affect,45–46,
47, 241, 258, 268
Pseudodementia,42, 148
Psychiatric disorders. See also Anxiety; Comorbidity; Depression; Neuropsychiatric disorders; Psychosis; specific disorderscatatonia and,228epilepsy and,154–160
Psychogenic amnesia,147–148
Psychogenic fugue,59
Psychogenic nonepileptic seizures (PNES),67, 68, 69, 70,
72–
73, 75,
76, 77–79, 271
Psychosis, and psychotic disordersanticonvulsants and,355
ASD and,291
dementia and,190, 202, 211, 214
differential diagnosis of,47–48
epilepsy and,155, 159–160
left-brain lesions and,137multiple sclerosis and,257
PD and,211–212, 347
right-brain dysfunction and,136
stroke and,240–241
Psychosocial treatment, of substance use disorder,278–279, 281
Psychotherapy. See also Cognitive-behavioral therapy; Motivational counselingfor depression,44
for FNSD,78
for TBI,267
P300 wave, and electroencephalography,14, 15
Quetiapine,195, 196, 211–212,
345Rabbit syndrome,229Radioactive iodine,307–308
Raphe,27Rapid eye movement (REM) sleep, and electroencephalography,13–14
Rasagiline,339
Rasmussen’s syndrome,152
Reading comprehension, and aphasia,107
Receptive aprosodia,136Receptive language,7
Receptive prosody,109
Reduplicative paramnesia,49, 135, 148
Reference, delusions of,50Reflex epilepsies,154
Reiterative speech disturbances,111, 113
Relapsing-remitting multiple sclerosis,253–254
Release hallucinations,50
Repetitive behaviorsaphasia and,107
dementia and,191, 202
differential diagnosis of,55–59
Repetitive transcranial magnetic stimulation (rTMS),78–79, 99, 362, 364
Residential addiction treatment programs,279
Responsive neurostimulation (RNS), and epilepsy,162–163
Rest tremor,229Reticular activating system (RAS),31
Retrieval deficit, and dorsolateral prefrontal syndrome,90
Retrograde amnesia (RA),141
Revisualization, and visuospatial disorders,135
Rey-Osterreith Complex Figure,129, 132
Right hemisphere, of brain,61,
104, 135–137, 240
Right spatial neglect,137Rigidity, and PD,206
Riluzole,233–234
Risk factors. See also Precipitating factors; Protective factorsfor Alzheimer’s disease,184
for cerebrovascular disease,234, 236
for delirium,169–170
for FNSD,68–69
for hyperthyroidism or hypothyroidism,302, 306
Risperidone,161, 293,
345Rivastigmine,189Rolandic epilepsy,153
Rufinamide,354Safinamide,339
Schizoid behavior, and right-brain lesions,136, 137
Screening. See also Assessmentfor alcohol use,275
for mood disorders in epilepsy patients,157–158
Secondary brain injury,265–266
Secondary memory,141
Secondary parkinsonism,215–216
Sedative-hypnotics,347–349
Segmental myoclonus,224–225
Seizures. See also Dacrystic seizures; Gelastic seizures; Psychogenic nonepileptic seizuresantidepressants and,342
antipsychotics and,345brain tumors and,247, 249
limbic encephalitis and,316
types of,151,
152, 153
Selective serotonin reuptake inhibitors (SSRIs). See also Antidepressantsdrug interactions and,339, 343
emotional sequelae of TBI and,268
mood disorders in patients with epilepsy and,158–159
patients with post-stroke depression and,242
Selegilene,337, 339
Self-awareness, and right-brain dysfunctions,137
Self-injurious behavior, differential diagnosis of,64
Semantic variant of primary progressive aphasia (svPPA),181,
186,
187, 193
Sensory homunculus, in human brain,38Sensory symptoms, of FNSD,74–
85Sepsis, and delirium,171Serial 7s subtraction test,6
Serotonin, clinical relevance of,25, 26
Serotonin augmenting agents, and antidepressants,340–341
Serotonin-norepinephrine reuptake inhibitors (SNRIs),158–159, 340
Serotonin syndrome, and monoamine oxidase inhibitors,339
Sexual behavior, differential diagnosis of altered,62–63.
See also Hypersexuality; Hyposexuality
Short-term memory,141, 144
“Silent strokes,”240
Simultanagnosia,120, 123
Single-photon emission computed tomography (SPECT),15, 20–21
Situational amnesia,147
Sleep disordersdelirium and,171dementia and,191, 195, 202
PD and,206–207
TBI and,270
Social behaviorsbasal ganglia and,30
lateral orbitofrontal syndrome and,95
medial frontal syndrome and,96
Social skills training, and ASD,292–293
“Soft signs,” neurological,8
Somatic delusions,50Somatic symptom(s), of TBI,270–271
Somatic symptom disorder (SSD),67
Somatoparaphrenia,50, 130
Somesthetic neglect,128
Spastic dysarthrias,110–111
Spatial agraphias,109
Speech, and assessment,3.
See also Language; Reiterative speech disturbances
Status epilepticus,151–152
Stereotypies, and ASD,291
Steroids, and multiple sclerosis,258–259
Stevens-Johnson syndrome,355
Stimulant(s), and ASD,294
Stimulant-induced chorea,217Striatum,29
Stroke. See also Cerebrovascular disease-stroke; Hemorrhagic strokesamnesia and,144, 146
ECT for,365etiologies of in young individuals,237–
238mania or hypomania,46neuropsychiatric syndromes associated with,238–241
risks of treatment for,241–243
Stroke Aphasia Depression Questionnaire,239
Stroop Color-Word Interference Test,94
Structural brain imaging, clinical indications for,15,
16Structured Clinical Interview for DSM-IV,157
Stuttering,111, 113
Subarachnoid hemorrhage,234,
235Substance abuse, and substance use disorders (SUDs). See also Alcohol use disordercatatonia and,228delirium and,171diagnosis of,275–278
medications for,279–282
myoclonus and,225neurobiology of addiction,274–275
psychosocial treatment of,278–279
stroke and,237Substantia innominata,29
Suicide, and suicidal ideationbrain tumors and,248
epilepsy and,155, 160
multiple sclerosis and,255
TBI and,269
Sydenham’s chorea,219
Sylvian fissure,31
Symbo- or figure-cancellation abnormalities,130
Sympathetic apraxia,114,
115, 116
Tactile hallucinations,53
Tardive akathisia,229Tardive dyskinesia (TD),217, 218–219,
229,
345, 346
Tardive dystonia,229Tardive myoclonus,229Taylor Complex Figure,132,
133Telehealth,282
Temporal lobe epilepsy,61, 163–164
Tetrabenazine,218, 222
Tetracyclic antidepressants,341
Thalamic aphasia,106Thalamus, and neuroanatomy,29, 33
Therapeutic drug monitoring (TDM),335–336
Theta burst stimulation (TBS),363
Thiamine deficiency, and amnesia,144Thiothixene,345Thyroid-stimulating hormone (TSH),301, 304,
305, 307
Thyrotropin-releasing hormone,42–43
Thyroxine,304
Tiagabine,354, 356
Tic syndromes,221–222,
229.
See also Tourette’s disorder
Tissue plasminogen activator (TPA),236
TI weighted images,17
Tonic-clonic seizures,151
Topiramate,281,
354, 356–357
Tourette’s disorder,221, 222,
229, 290–291
“Tower” tests, and dorsolateral prefrontal syndrome,91
Toxicity, and toxic disordersanticonvulsants and,356dementia and,200MAOIs and,339
white matter diseases and,252Transcortical aphasia,96,
106, 107
Transcranial magnetic stimulation (TMS)ASD and,295
epilepsy and,161
interventional psychiatry and,362–363
patients with post-stroke depression and,242–243
Transient global amnesia,59, 145–146
Transient ischemic attacks (TIAs),234,
235Tranylcypromine,337
Traumatic brain injury (TBI)amnesia and,141, 143,
144assessment and,267
chronic traumatic encephalopathy and,194
dementia and,201epilepsy and,163
frontal lobe disorders and,98mania or hypomania,46neuropsychiatric aspects of,268–271
parkinsonism and,216
pathophysiology of,265–266
post-concussive syndrome and,271
stroke and,238treatment of,267, 268–271
Traumatic encephalopathy syndrome,182,
186, 187.
See also Chronic traumatic encephalopathy
Trazodone,340–341
Treatment. See also Cognitive-behavioral therapy; Electroconvulsive therapy; Pharmacotherapy; Prevention; Psychotherapyof Alzheimer’s disease,185, 188
of amnesia,146
of anxiety disorders,55
of ataxia,223–224
of ASD,291–295
of brain tumors,248–249
of catatonia,227
of cerebrovascular disease,236–238, 241–243
of delusions,48
of depression,43–44
of delirium,172–174
of dementia,194, 201–202
of epilepsy,161–163
of FNSD,77–79
of frontal lobe syndromes,97, 99–100
of HIV-associated neurocognitive disorders,327–329
of Huntington’s disease,218
of hypercortisolemia,312
of hyperthyroidism,307–308
of hypocortisolemia,310
of hypothyroidism,304–305
of limbic encephalitis,319–320
of mania and hypomania,45
of multiple sclerosis,255, 258
of myoclonus,224–225
of OCD,56, 59
of PD,207–209, 212–213
of psychiatric disorders in patients with epilepsy,158–159, 160–162
of substance use disorder,278–279
of tic syndromes,222
of TBI,267
Tremor,74, 206, 225,
226Tricyclic antidepressants (TCAs),158–159, 340
Triiodothyronine (T3),305
Tuberculous meningitis, and amnesia,144Uncinate fasciculus,33
Unicyclic antidepressants,341
Unilateral visual neglect,127–129
U.S. Preventive Services Task Force,275
Utilization behavior, and dorsolateral prefrontal syndrome,94
Vagus nerve stimulation (VNS),162, 367–368
Valbenazine,222
Valproate,294,
352Vascular cognitive disorder,182, 183,
186,
188, 197–198
Vascular dementia (VaD),201, 238–239
Vascular parkinsonism,216
Venlafaxine,158
Ventral tegmental area,27Verbal amnesia,137Verbal fluency, and dorsolateral prefrontal syndrome,90
Verbal perseveration,113
Vertical supranuclear gaze palsy,213
Video electroencephalogram,71
Video telemetry,15
Vigabatrin,354Vilazodone,341
Viral escape, and HIV,330
Visual discrimination deficits,124
Visual hallucinations,48, 50–51,
52, 121, 136–137, 211, 241.
See also Hallucinations Visual object agnosia,120,
125, 126–127
Visual recognition disorders,124–127
Visual search, and visuospatial disorders,134–135
Visuoperceptual disorders,119–123
Visuospatial attention,127–130
Visuospatial disorders,134–135,
136Vitamin B12 deficiency,260
Voice discrimination and recognition deficits,136Vorbeireden,147–148
Vortioxetine,341
Wada test,162
Waveforms, and electroencephalography,13–14
Wernicke’s aphasia,106, 107, 240
Wernicke’s encephalopathy,145
West’s syndrome,153
White matter disordersdementia and,199,
200–
201frontal lobe dysfunction and,97
leukoaraiosis and,260–261
leukodystrophies and,261
multiple sclerosis and,251–259
neuromyelitis optica and,259
progressive multifocal leukoencephalopathy and,259–260
vitamin B12 deficiency and,260
Wilson’s disease,217Wisconsin Card Sorting Test,91
Withdrawal, and substance use disorders,276, 281
Witzelsucht,47,
61Working memory,141
World Health Organization,281, 285
World Health Organization Classification of Tumors of the Central Nervous System (2016),245
Writing, and aphasia,107
X-linked ataxia,223Ziprasidone,345Zonisamide,354