American Journal of Psychiatry
- Volume 154
- Number 1
- January 1997
Publication date: 01 January 1997
Pages4–17OBJECTIVE: The authors summarize current knowledge regarding the psychomotor symptoms of depression. METHOD: Findings from the objective quantification of psychomotor symptoms are reviewed, and methodological issues are considered. The contemporary ...
https://doi.org/10.1176/ajp.154.1.4Publication date: 01 January 1997
Pages18–24OBJECTIVE: Both the magnitude of brain atrophy and premorbid brain size determine the volume of the brain affected by Alzheimer's disease. To examine the possibility that premorbid brain volume is a determinant of cognitive reserve in patients with ...
https://doi.org/10.1176/ajp.154.1.18Publication date: 01 January 1997
Pages25–30OBJECTIVE: Although loss of noradrenergic neurons in the locus ceruleus has been consistently demonstrated postmortem in Alzheimer's disease, several small studies suggest that indices of central noradrenergic activity increase with the severity of ...
https://doi.org/10.1176/ajp.154.1.25Publication date: 01 January 1997
Pages31–36OBJECTIVE: Demonstration of antidepressant efficacy beyond 6 months has infrequently been addressed, and no long-term efficacy data exist for patients with chronic atypical depression. METHOD: Sixty patients with atypical depression (according to Columbia ...
https://doi.org/10.1176/ajp.154.1.31Publication date: 01 January 1997
Pages37–43OBJECTIVE: In two preliminary studies, pindolol produced robust results in hastening clinical response to antidepressant drugs in depressed patients. Validity of those pilot studies was limited by use of an open- label, unblinded study design, and so the ...
https://doi.org/10.1176/ajp.154.1.37Publication date: 01 January 1997
Pages44–49OBJECTIVE: Although available data suggest that bipolar disorder most commonly begins in adolescence, it has often been underrecognized and misdiagnosed in this age group. The authors hypothesized that this might in part be because adolescent mania is ...
https://doi.org/10.1176/ajp.154.1.44Publication date: 01 January 1997
Pages50–55OBJECTIVE: The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity. METHOD: They used positron emission ...
https://doi.org/10.1176/ajp.154.1.50Publication date: 01 January 1997
Pages56–63OBJECTIVE: Although there is evidence from postmortem studies suggestive of deficient inhibitory neurotransmission of gamma- aminobutyric acid (GABA) in schizophrenia, no direct in vivo evidence has been obtained to date. The authors used single photon ...
https://doi.org/10.1176/ajp.154.1.56Publication date: 01 January 1997
Pages64–68OBJECTIVE: The purpose of this study was to examine the relationships between clinical and neurobiological measures of childhood-onset schizophrenia. It was hypothesized that there would be a more striking pattern in the rare cases with very early onset ...
https://doi.org/10.1176/ajp.154.1.64Publication date: 01 January 1997
Pages69–74OBJECTIVE: Pediatric studies of cerebrospinal fluid (CSF) monoamine metabolites in childhood-onset schizophrenia may help to elucidate both pathophysiology and treatment response in early-onset psychosis. METHOD: CSF homovanillic acid (HVA), 5-...
https://doi.org/10.1176/ajp.154.1.69Publication date: 01 January 1997
Pages75–80OBJECTIVE: The usefulness of carbohydrate-deficient transferrin is widely accepted in screening (male) population samples for heavy alcohol consumption, but its role in relapse detection is not convincingly established. The authors therefore compared the ...
https://doi.org/10.1176/ajp.154.1.75Publication date: 01 January 1997
Pages81–87OBJECTIVE: The purpose of this study was to explore central serotonergic functions in subgroups of alcoholics and in healthy comparison subjects. METHOD: The mixed serotonin (5-HT) agonist/antagonist m-chlorophenylpiperazine (m-CPP) was administered to ...
https://doi.org/10.1176/ajp.154.1.81Publication date: 01 January 1997
Pages88–93OBJECTIVE: The authors determined the rates and patterns of violence toward persons by psychiatric patients before admission to the inpatient service of the Payne Whitney Clinic and determined which factors were associated with a greater risk of violence. ...
https://doi.org/10.1176/ajp.154.1.88Publication date: 01 January 1997
Pages94–98OBJECTIVE: The authors sought to evaluate how the services required by the Italian Psychiatric Reform of 1978 were implemented in Emilia- Romagna, a region of 4 million inhabitants in Northern Italy. METHOD: All psychiatric facilities were monitored from ...
https://doi.org/10.1176/ajp.154.1.94Publication date: 01 January 1997
Pages99–105OBJECTIVE: The purposes of the study were 1) to characterize the quality of life of three patient groups with chronic mental illness, 2) to evaluate differences in reported life quality among the three groups, and 3) to evaluate the validity of a self-...
https://doi.org/10.1176/ajp.154.1.99Publication date: 01 January 1997
Pages110–112OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive- compulsive disorder and tic disorders) ...
https://doi.org/10.1176/ajp.154.1.110Publication date: 01 January 1997
Pages113–115OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Two common COMT alleles determine high and low activity of the enzyme. Previous studies using biochemical methods found lower enzyme activity in patients with ...
https://doi.org/10.1176/ajp.154.1.113Publication date: 01 January 1997
Pages116–118OBJECTIVE: The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects. METHOD: In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region ...
https://doi.org/10.1176/ajp.154.1.116Publication date: 01 January 1997
Pages119–121OBJECTIVE: The purpose of this study was to evaluate gender differences in baseline measures of regional brain metabolism and to assess their reproducibility. METHOD: Fifteen male and 13 female healthy subjects, whose mean age was 44 years, were tested ...
https://doi.org/10.1176/ajp.154.1.119Publication date: 01 January 1997
Pages122–123OBJECTIVE: The authors determined the risk of suicide during pregnancy. METHOD: The autopsy reports of all female residents of New York City, 10-44 years old, who committed suicide from 1990 to 1993 were assessed for pregnancy. These data were compared ...
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