Association of the Alzheimer's Gene SORL1 With Hippocampal Volume in Young, Healthy Adults
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Sample
Age (Years) | |||||
---|---|---|---|---|---|
Cohort | N | Mean | SD | Gender (Male/Female) | Single Nucleotide Polymorphisms Analyzed |
Discovery (scanned with 1.5-T) | 446 | 22.9 | 3.54 | 258/188 | 117 |
Replication (scanned with 3.0-T) | 490 | 22.6 | 3.14 | 291/199 | 115 |
Combined | 936 | 22.8 | 3.34 | 549/387 | 117 |
Apolipoprotein E subsample | 735 | 22.8 | 3.28 | 299/436 | 117 |
Genotyping
Neuroimaging Procedures
Brain Segmentation
Analysis
Results
Discovery Cohort (N=446) | Replication Cohort (N=490) | Combined Cohort (N=936) | ||||||
---|---|---|---|---|---|---|---|---|
SNP | Positionb | Unadjusted (p) | Empirical (p) | Unadjusted (p) | Empirical (p) | Unadjusted (p) | Empirical (p) | Type |
rs17125342 | 120813518 | 0.55 | 1.0 | 0.03 | 0.73 | 0.04 | 0.88 | upstream |
rs661057c | 120834164 | 0.94 | 1.0 | 0.01 | 0.39 | 0.05 | 0.89 | intron 2 |
rs1784934 | 120843203 | 0.59 | 1.0 | 0.02 | 0.66 | 0.04 | 0.82 | intron 2 |
rs3781826 | 120848256 | 0.0001 | 0.009 | 0.71 | 1.0 | 0.03 | 0.81 | intron 3 |
rs676759 | 120864475 | 0.21 | 1.0 | 0.001 | 0.07 | 0.001 | 0.06 | intron 5 |
rs560573 | 120866094 | 0.16 | 1.0 | d | d | 0.0004 | 0.02 | intron 6 |
rs593769 | 120869213 | 0.16 | 1.0 | 0.0011 | 0.06 | 0.0006 | 0.03 | intron 6 |
rs12364988 | 120872836 | 0.18 | 1.0 | 0.0024 | 0.13 | 0.0013 | 0.07 | exon 7 |
rs668387c | 120873131 | 0.14 | 1.0 | 0.0003 | 0.02 | 0.0002 | 0.01 | intron 7 |
rs923892 | 120873373 | 0.17 | 1.0 | 0.0003 | 0.02 | 0.0002 | 0.01 | intron 7 |
rs666004 | 120903788 | 0.30 | 1.0 | 0.02 | 0.58 | 0.01 | 0.44 | intron 12 |
rs7933552 | 120922038 | 0.98 | 1.0 | 0.00 | 0.19 | 0.03 | 0.75 | intron 15 |
rs640479 | 120937693 | 0.09 | 1.0 | 0.06 | 0.93 | 0.01 | 0.53 | intron 22 |
rs924746 | 120948247 | 0.02 | 0.70 | 0.09 | 1.0 | 0.01 | 0.32 | intron 24 |
rs3781834 | 120951150 | 0.66 | 1.0 | 0.00 | 0.15 | 0.01 | 0.43 | intron 25 |
rs4420280 | 120951269 | 0.04 | 0.83 | 0.12 | 1.0 | 0.01 | 0.47 | intron 25 |
rs3781836 | 120953548 | 0.89 | 1.0 | 0.00 | 0.20 | 0.05 | 0.89 | intron 26 |
rs1699103 | 120957136 | 0.08 | 0.97 | 0.16 | 1.0 | 0.03 | 0.77 | intron 26 |
rs7116734 | 120957150 | 0.02 | 0.61 | 0.11 | 1.0 | 0.01 | 0.33 | intron 26 |
rs1620003 | 120978203 | 0.07 | 0.96 | 0.15 | 1.0 | 0.03 | 0.71 | intron 33 |
rs1629493 | 120982306 | 0.05 | 0.89 | 0.33 | 1.0 | 0.04 | 0.87 | intron 37 |
rs1784931 | 120988148 | 0.06 | 0.93 | 0.19 | 1.0 | 0.03 | 0.72 | intron 40 |
rs540860 | 121036098 | 0.28 | 1.0 | 0.03 | 0.78 | 0.02 | 0.67 | downstream |
rs663175 | 121039037 | 0.44 | 1.0 | 0.02 | 0.62 | 0.03 | 0.72 | downstream |
rs647905 | 121040148 | 0.40 | 1 | 0.02 | 0.68 | 0.03 | 0.72 | downstream |
rs568599 | 121041221 | 0.33 | 1 | 0.02 | 0.52 | 0.01 | 0.53 | downstream |
rs11218381 | 121067926 | 0.01 | 0.31 | 0.09 | 1 | 0.003 | 0.17 | downstream |
rs10502260 | 121073107 | 0.01 | 0.53 | 0.52 | 1 | 0.03 | 0.80 | downstream |
rs2887763 | 121073389 | 0.02 | 0.58 | 0.04 | 0.85 | 0.003 | 0.17 | downstream |
rs10892771 | 121073472 | 0.04 | 0.87 | 0.02 | 0.53 | 0.003 | 0.15 | downstream |
Discussion
Acknowledgments
Footnotes
Supplementary Material
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