Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Participants
Clinical Assessment
Image Acquisition
[11C]IMA107 PET Data Processing
Movement minimization and correction.
Data analysis.
Image processing and definition of regions of interest.
Kinetic modeling.
Statistical Analysis
Results
Measure | Schizophrenia Patients (N=12) | Healthy Comparison Subjects (N=12) | ||
---|---|---|---|---|
N | % | N | % | |
Male | 8 | 67 | 8 | 67 |
Right-handed | 12 | 100 | 12 | 100 |
Education | ||||
High school diploma (GCSE) | 6 | 50 | 2 | 17 |
High school diploma, advanced (A-level) | 3 | 25 | 4 | 33 |
University | 3 | 25 | 6 | 50 |
Antipsychotics used (% of atypicals) | 9 | 75 | ||
Mean | SD | Mean | SD | |
Age at scan (years) | 33.16 | 6.88 | 32.58 | 7.06 |
Cotinine blood level (ng/ml) | 372.90 | 345.30 | 296.70 | 287.90 |
Caffeine blood level (mg/L) | 3.10 | 0.60 | 3.08 | 0.23 |
Positive and Negative Syndrome Scale score | 61.50 | 9.70 | ||
Antipsychotic dosage (mg per day of chlorpromazine equivalents) | 259.70 | 169.90 | ||
Radioactivity injected (MBq) | 275.30 | 43.50 | 261.20 | 57.90 |
Specific activity (GBq/μmol) | 2.95 | 1.74 | 3.25 | 1.80 |
Schizophrenia Patients (N=12) | Healthy Comparison Subjects (N=12) | % Change in Patientsa | |||
---|---|---|---|---|---|
Region of Interest | Mean | SD | Mean | SD | |
Thalamus | 0.47 | 0.09 | 0.43 | 0.09 | 8 |
Substantia nigra | 0.63 | 0.16 | 0.67 | 0.18 | –6 |
Caudate | 1.26 | 0.20 | 1.28 | 0.26 | –1 |
Putamen | 2.39 | 0.35 | 2.26 | 0.35 | 6 |
Nucleus accumbens | 0.87 | 0.18 | 0.88 | 0.15 | –2 |
Globus pallidus | 2.20 | 0.30 | 2.17 | 0.40 | 2 |
Correlations Between PDE-10A Availability and Clinical Characteristics
Discussion
Footnote
Supplementary Material
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