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Chapter 23.Buspirone

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as23

Sections

The 5-HT1A Receptor | History and Development | Pharmacological Profile | Pharmacokinetics and Mechanism of Action | Indications and Efficacy | Dosage and Administration | Side Effects and Toxicology | Conclusion | References

Excerpt

Altered central serotonergic function is implicated in several psychiatric disorders, especially mood and anxiety disorders. Discovery of the serotonin-1A (5-HT1A) receptor linked modulation of serotonin (5-hydroxytryptamine [5-HT]) neurotransmission to anxiety symptoms. Similarly, tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) linked serotonin to the pathophysiology and treatment of depression.

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