Systematic Review of an Emerging Trend in China: Resting-State Functional Connectivity in Major Depressive Disorder
Abstract
Data Analysis | MDD>HC | MDD<HC | Reference |
---|---|---|---|
First-episode, treatment-naïve depressed subjects | |||
ReHo | Left middle temporal gyrus genotype- dependent | 92 | |
ReHo | No differences | No differences | 93 |
Seed-based anterior cingulate cortex and thalamus | Left parahippocampus, parietal lobe and frontal lobe | Right parietal lobe and cingulate gyrus | 45 |
Seed-based left posterior cingulate cortex | Bilateral dorsolateral prefrontal cortex and inferior parietal lobe | Medial prefrontal cortex / orbitofrontal cortex | 46 |
VMHC | Medial prefrontal cortex and posterior cingulate cortex / precuneus | 47 | |
ALFF | Fusiform gyri and anterior and posterior lobes of the cerebellum | Left inferior temporal gyrus and right inferior parietal lobe | 1 |
ALFF | Left superior occipital gyrus and cuneus | Right cerebellum posterior lobe, left parahippocampal gyrus and right middle frontal gyrus | 39 |
ALFF | Right dorsolateral frontal cortex, bilateral inferior frontal gyrus and orbital frontal region | Left insula, bilateral caudate and left hippocampus | 43 |
Network analysis | Left hippocampus and right parahippocampal gyrus | Left superior orbitofrontal cortex and left medial frontal cortex | 48 |
Graph analysis | Anterior cingulate cortex, dorsolateral, medial and inferior prefrontal cortex, insula, amgydala and superior and middle temporal gyri | 44 | |
Depressed outpatients | |||
ReHo | Insula, cerebellum anterior lobe, middle frontal gyrus, superior temporal gyrus, lentiform nucleus, precentral gyrus and postcentral gyrus | Interior frontal gyrus, inferior parietal lobule and posterior lobe of the cerebellum | 50 |
ReHo and ROI analysis | Bilateral anterior cingulate cortex, medial prefrontal cortex, right insula and right parahippocampalgyrus | Left posterior fusiform gyrus, inferior frontal area, inferior parietal lobule and caudate | 51 |
ReHo | Right orbitofrontal cortex, fusiform gyrus, ventral anterior cingulate gyrus, posterior cingulate gyrus. Left dorsal anterior cingulated gyrus and lentiform nucleus | 55 | |
ReHo | Right inferior temporal gyrus | Left posterior lobe of the cerebellum, right fusiform gyrus, left parahippocampal gyrus and right postcentral gyrus | 56 |
ReHo | Left thalamus, left temporal lobe, bilateral occipital lobe and left posterior lobe of the cerebellum | 94 | |
Seed-based cerebellar regions | Regions of the cerebellum, left middle frontal cortex and poles of the temporal cortex | Regions of the cerebellum, posterior cingulate cortex, ventromedial prefrontal cortex, superior frontal gyri, left orbitalfrontal gyrus and hippocampus | 12 |
Seed-based right dorsolateral prefrontal cortex | Right dorsolateral prefrontal cortex, left anterior cingulate cortex, left parahippocampal gyrus, thalamus and precentral gyrus | Right dorsolateral prefrontal cortex and right parietal lobe | 52 |
Seed-based left and right hippocampus | Left and right hippocampus, middle frontal gyrus, inferior parietal lobe and cerebellum | 53 | |
Seed-based left and right amygdala | Amygdala and left ventral prefrontal cortex | 54 | |
Seed-based 16 ROIs | Left thalamus and right cingulate cortex; right insula and precuneus | 57 | |
ALFF | Right dorsomedial frontal gyrus and right precuneus | Bilateral lingual gyri | 49 |
Treatment-resistant, depressed subjects | |||
ReHo | Left superior temporal gyrus, anterior and posterior lobe of the cerebellum, right cerebellar tonsil and bilateral fusiform gyrus | Left insula, superior temporal gyrus, inferior frontal gyrus, lingual gyrus and anterior lobe of the cerebellum | 95 |
Seed-based 16 ROIs | Precuneus, left middle frontal gyrus and cingulate cortex | 57 | |
Seed-based gray matter volume of right middle temporal gyrus and right caudate nucleus | Right precuneus, middle temporal gyrus, bilateral superior frontal gyrus and left middle frontal gyrus | Right cuneus | 63 |
Elderly depressed subjects | |||
ReHo | Left anterior insula, right posterior insula and right dorsolateral prefrontal cortex | Right orbitofrontal cortex, left middle frontal gyrus, left dorsolateral prefrontal, left inferior temporal gyrus and left postcentral gyrus | 67 |
ReHo | Superior frontal gyrus, postcentral gyrus and putamen | Superior and middle frontal and temporal gyri, postcentral gyrus, fusiform gyrus and precuneus | 68 |
Cohe-ReHo | Left posterior lobe of the cerebellum, left superior temporal gyrus, bilateral supplementary motor area and right postcentral gyrus | Left caudate nucleus, right anterior cingulate gyrus, left dorsolateral prefrontal cortex, right angular gyrus, bilateral medial prefrontal cortex and right precuneus | 64 |
Seed-based posterior cingulate cortex | Posterior cingulate cortex and temporal cortex | Posterior cingulate cortex and frontal cortex | 65 |
Suicidal, traumatized, or somatically ill depressed subjects | |||
ALFF | Parahippocampal gyrus, anterior cingular gyrus and angular gyrus of the parietal lobe | 69 | |
ALFF | Anterior and posterior lobes of the cerebellum | Right dorsolateral prefrontal cortex, ventromedial prefrontal cortex, superior frontal cortex, right middle temporal gyrus and rostral anterior cingulate cortex | 71 |
Graph analysis | Prefrontal cortex and anterior cingulate gyrus | 70 |
Methods
Literature Search
Main Features of Resting-State Neuroimaging
Main Features of Resting-State Functional Connectivity MRI
Main Principles of rs-fcMRI Data Analysis
Results
First-Episode, Treatment-Naïve Depressed Subjects
Depressed Outpatients
Treatment-Resistant Depressed Subjects
Elderly Depressed Subjects
Suicidal, Traumatized, or Somatically Ill Depressed Subjects
Discussion
Acknowledgments
References
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