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Published Online: December 1962

THE EFFECT OF MP-809 IN DEPRESSIVE STATES: A MULTI-BLIND STUDY

H. AZIMA, DOROTHY ARTHURS, A. SILVER, and FERN J. AZIMAAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 119, Number 6

https://doi.org/10.1176/ajp.119.6.573

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Abstract

1. A new substance, MP-809, a tryptamine derivative, was investigated in 50 depressed patients, as compared to two other groups of 50 depressed patients receiving inert and potent placebo, in a multiblind controlled setting.

2. Clinically MP-809 had a significant (marked to moderate) antidepressant activity in 52% of all patients and in 74.1% of neurotic depressions. Statistically the results were significantly in favour of MP-809 as compared with the two placebos, and this significance reached the high level of P<0.001 in neurotic depressions.

3. Side effects were frequent but minimal in their intensity.

4. The final conclusion was that MP-809 is a potent antidepressant agent particularly in neurotic depressive states.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 119 • Number 6 • December 1962

Pages: 573 - 574

PubMed: 13965759

History

Published in print: December 1962

Published online: 1 April 2006

Authors

Details

H. AZIMA

McGill University, Dept. of Psychiatry, Allan Memorial Institute, Psychopharmacology Section.

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DOROTHY ARTHURS

McGill University, Dept. of Psychiatry, Allan Memorial Institute, Psychopharmacology Section.

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A. SILVER

McGill University, Dept. of Psychiatry, Allan Memorial Institute, Psychopharmacology Section.

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FERN J. AZIMA

McGill University, Dept. of Psychiatry, Allan Memorial Institute, Psychopharmacology Section.

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THE EFFECT OF MP-809 IN DEPRESSIVE STATES: A MULTI-BLIND STUDY

Abstract

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