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Published Online: 1 April 2016

Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs

Yang Sheng, B.S., Emily Filichia, B.S., Elizabeth Shick, B.S., Kenzie L. Preston, Ph.D., Karran A. Phillips, M.D., Leslie Cooperman, B.S., Zhicheng Lin, Ph.D., Paul Tesar, Ph.D., Barry J. Hoffer, M.D., Ph.D., and Yu Luo, Ph.D.Authors Info & Affiliations
Publication: American Journal of Psychiatry
Volume 173, Number 4
https://doi.org/10.1176/appi.ajp.2015.15121545
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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Volume 173 • Number 4 • April 01, 2016
Pages: 429 - 431
PubMed: 27035534

History

Accepted: December 2015
Published online: 1 April 2016
Published in print: April 01, 2016

Authors

Details

Yang Sheng, B.S.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Emily Filichia, B.S.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Elizabeth Shick, B.S.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Kenzie L. Preston, Ph.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Karran A. Phillips, M.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Leslie Cooperman, B.S.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Zhicheng Lin, Ph.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Paul Tesar, Ph.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Barry J. Hoffer, M.D., Ph.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Yu Luo, Ph.D.
From the Departments of Neurological Surgery and of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland; the Intramural Research Program, Clinical Trials Treatment Branch, the Clinical Pharmacology and Therapeutics Research Branch, and the Cellular Neurobiology Branch, NIDA, Baltimore; and the Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.
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Funding Information

National Institute on Drug Abuse10.13039/100000026: R21DA032962, Intramural Research Program
Supported by NIDA grant R21DA032962 to Dr. Tesar and Dr. Luo, by NIDA grant DA021409 to Dr. Lin, and by the Intramural Research Program of NIDA.The authors report no financial relationships with commercial interests.

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