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Published Online: 5 April 2019

Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths

Thorhildur Halldorsdottir, Ph.D. [email protected], Charlotte Piechaczek, M.S., Ana Paula Soares de Matos, Ph.D., Darina Czamara, Ph.D., Verena Pehl, Ph.D., Petra Wagenbuechler, Lisa Feldmann, M.S., Peggy Quickenstedt-Reinhardt, Dipl.-Psych., Antje-Kathrin Allgaier, Ph.D., Franz Joseph Freisleder, Ph.D., Ellen Greimel, Ph.D., Tuomas Kvist, M.A., Jari Lahti, Ph.D., Katri Räikkönen, Ph.D., Monika Rex-Haffner, Eiríkur Örn Arnarson, Ph.D., W. Edward Craighead, Ph.D., Gerd Schulte-Körne, Ph.D., and Elisabeth B. Binder, M.D., Ph.D. [email protected]Authors Info & Affiliations
Publication: American Journal of Psychiatry
Volume 176, Number 8
https://doi.org/10.1176/appi.ajp.2019.18091014
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Abstract

Objective:

Identifying risk factors for major depression and depressive symptoms in youths could have important implications for prevention efforts. This study examined the association of polygenic risk scores (PRSs) for a broad depression phenotype derived from a large-scale genome-wide association study (GWAS) in adults, and its interaction with childhood abuse, with clinically relevant depression outcomes in clinical and epidemiological youth cohorts.

Methods:

The clinical cohort comprised 279 youths with major depression (mean age=14.76 years [SD=2.00], 68% female) and 187 healthy control subjects (mean age=14.67 years [SD=2.45], 63% female). The first epidemiological cohort included 1,450 youths (mean age=13.99 years [SD=0.92], 63% female). Of those, 694 who were not clinically depressed at baseline underwent follow-ups at 6, 12, and 24 months. The replication epidemiological cohort comprised children assessed at ages 8 (N=184; 49.2% female) and 11 (N=317; 46.7% female) years. All cohorts were genome-wide genotyped and completed measures for major depression, depressive symptoms, and/or childhood abuse. Summary statistics from the largest GWAS to date on depression were used to calculate the depression PRS.

Results:

In the clinical cohort, the depression PRS predicted case-control status (odds ratio=1.560, 95% CI=1.230–1.980), depression severity (β=0.177, SE=0.069), and age at onset (β=−0.375, SE=0.160). In the first epidemiological cohort, the depression PRS predicted baseline depressive symptoms (β=0.557, SE=0.200) and prospectively predicted onset of moderate to severe depressive symptoms (hazard ratio=1.202, 95% CI=1.045–1.383). The associations with depressive symptoms were replicated in the second epidemiological cohort. Evidence was found for an additive, but not an interactive, effect of the depression PRS and childhood abuse on depression outcomes.

Conclusions:

Depression PRSs derived from adults generalize to depression outcomes in youths and may serve as an early indicator of clinically significant levels of depression.

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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Volume 176 • Number 8 • August 01, 2019
Pages: 615 - 625
PubMed: 30947532

History

Received: 2 September 2018
Revision received: 23 November 2018
Revision received: 22 January 2019
Accepted: 28 January 2019
Published online: 5 April 2019
Published in print: August 01, 2019

Keywords

  1. Prevention
  2. Mood Disorders-Unipolar
  3. Early-Onset Depression
  4. Polygenic Risk
  5. At-Risk Youth
  6. Childhood Abuse

Authors

Affiliations

Thorhildur Halldorsdottir, Ph.D. [email protected]
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Charlotte Piechaczek, M.S.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Ana Paula Soares de Matos, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Darina Czamara, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Verena Pehl, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Petra Wagenbuechler
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Lisa Feldmann, M.S.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Peggy Quickenstedt-Reinhardt, Dipl.-Psych.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Antje-Kathrin Allgaier, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Franz Joseph Freisleder, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Ellen Greimel, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Tuomas Kvist, M.A.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Jari Lahti, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Katri Räikkönen, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Monika Rex-Haffner
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Eiríkur Örn Arnarson, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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W. Edward Craighead, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Gerd Schulte-Körne, Ph.D.
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Elisabeth B. Binder, M.D., Ph.D. [email protected]
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich (Halldorsdottir, Czamara, Rex-Haffner, Binder); Center of Public Health Sciences (Halldorsdottir) and Landspitali National University Hospital, School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik (Arnarson); Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig Maximilian University, Munich (Piechaczek, Pehl, Wagenbuechler, Feldmann, Quickenstedt-Reinhardt, Allgaier, Greimel, Schulte-Körne); Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal (Soares de Matos); Department of Psychology, Faculty of Social Sciences, University of the German Federal Armed Forces, Neubiberg, Germany (Allgaier); KBO Heckscher Hospital, Munich (Freisleder); Department of Psychology and Logopedics, University of Helsinki, Helsinki (Kvist, Lahti, Räikkönen); Department of Psychiatry and Behavioral Sciences (Craighead, Binder) and Department of Psychology (Craighead), Emory University School of Medicine, Atlanta; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (see online supplement for list of researchers).
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Notes

Send correspondence to Dr. Halldorsdottir ([email protected]) and Dr. Binder ([email protected]).

Author Contributions

Drs. Craighead, Schulte-Körne, and Binder contributed equally to this article.

Funding Information

Dr. Halldorsdottir receives funding from European Research Council Consolidator Grant 726413. Drs. Arnarson and Craighead are board members of Hugarheill, an Icelandic company dedicated to the prevention of depression. Dr. Craighead receives book royalties from John Wiley & Sons; he has received research support from the Fuqua Family Foundation, the Mary and John Brock Foundation, and NIH; and he is a consultant to the George West Mental Health Foundation and AIM for Mental Health Foundation. Dr. Binder is a co-inventor on a patent on FKBP5, a novel target for antidepressant therapy (European patent 1687443 B1), and receives research funding from Boehringer Ingelheim for a collaboration on functional investigations of FKBP5. The other authors report no financial relationships with commercial interests.

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