American Journal of Psychiatry

Objective:Identifying risk factors for major depression and depressive symptoms in youths could have important implications for prevention efforts. This study examined the association of polygenic risk scores (PRSs) for a broad depression phenotype ...

https://doi.org/10.1176/appi.ajp.2019.18091014

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Neurobiology of Self-Regulation: Longitudinal Influence of FKBP5 and Intimate Partner Violence on Emotional and Cognitive Development in Childhood

Publication date: 05 April 2019

Pages626–634

Objective:Self-regulation includes the volitional and nonvolitional regulation of emotional, cognitive, and physiological responses to stimulation. It develops from infancy through individual characteristics and the environment, with the stress hormone ...

https://doi.org/10.1176/appi.ajp.2019.18091018

Identifying Novel Types of Irritability Using a Developmental Genetic Approach

Publication date: 01 July 2019

Pages635–642

Objective:Irritability, which is strongly associated with impairment and negative outcomes, is a common reason for referral to mental health services but is a nosological and treatment challenge. A major issue is how irritability should be conceptualized. ...

https://doi.org/10.1176/appi.ajp.2019.18101134

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A Third Linear Association Between Olduvai (DUF1220) Copy Number and Severity of the Classic Symptoms of Inherited Autism

Publication date: 15 February 2019

Pages643–650

Objective:The authors previously reported that the copy number of sequences encoding an Olduvai protein domain subtype (CON1) shows a linear association with the severity of social deficits and communication impairment in individuals with autism. In this ...

https://doi.org/10.1176/appi.ajp.2018.18080993

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GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Publication date: 05 June 2019

Pages651–660

Objective:More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors ...

https://doi.org/10.1176/appi.ajp.2019.18080957

CME

The Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank

Publication date: 04 January 2019

Pages661–666

Objective:Schizophrenia is associated with a marked reduction in reproductive success, yet alleles that are common contribute substantially to the liability of the disorder. Among several possible explanations for this, it has been postulated that ...

https://doi.org/10.1176/appi.ajp.2018.18020140