Predictive Value of Acute Neuroplastic Response to rTMS in Treatment Outcome in Depression: A Concurrent TMS-fMRI Trial
Abstract
Objective:
Methods:
Results:
Conclusions:
Methods
Participants
Characteristic | ||
---|---|---|
Mean | SD | |
Age (years) | 41.84 | 16.12 |
Educationa (years) | 15.21 | 2.12 |
Crystallized cognition scoreb | 109.39 | 15.45 |
N | % | |
Female | 26 | 68 |
Right-handed | 32 | 84 |
Unemployed | 19 | 50 |
Mean | SD | |
Length of current episode (months) | 46.08 | 68.00 |
Antidepressant Treatment History Form | ||
Score | 9.18 | 4.83 |
N | % | |
One failed trial | 21 | 55 |
Two failed trials | 13 | 34 |
Three or more failed trials | 4 | 11 |
Psychotropic medication | 33 | 87 |
None | 5 | 13 |
Antidepressants | 32 | 84 |
Benzodiazepines | 9 | 24 |
Antipsychotics | 16 | 42 |
Mood stabilizers | 2 | 5 |
Sedatives | 5 | 13 |
Stimulants | 9 | 24 |
Combination of psychotropics | 33 | 87 |
Mean | SD | |
Antidepressant dosage (escitalopram equivalents, mg) | 24.05 | 21.48 |
Benzodiazepine dosage (lorazepam equivalents, mg) | 0.53 | 1.06 |
Montgomery-Åsberg Depression Rating Scale | ||
Score at study entry | 29.50 | 6.84 |
Score at study end | 18.63 | 9.62 |
N | % | |
Responderc | 16 | 42 |
Remitterd | 8 | 21 |
Neuroimaging Acquisition and Concurrent rTMS-fMRI Procedures
Construction of the Whole-Brain Functional Network
Repetitive Transcranial Magnetic Stimulation Treatment
Statistical Analysis
Assessment of rTMS-induced connectivity changes.
Connectome-based predictive modeling of clinical outcome.
Sensitivity Analysis
Results
rTMS-Induced Functional Connectivity Changes
Connectome-Based Predictive Modeling of Clinical Outcome
Results of Sensitivity Analysis
Discussion
Acute Neuroplastic Response to rTMS Predicts Treatment Outcome
The Relevance of Macro-Level Neuroplasticity for Depression
Low-Frequency Right DLPFC rTMS Is Associated With Widespread Distal Functional Connectivity Changes
Limitations and Future Directions
Conclusions
Acknowledgments
Footnote
Supplementary Material
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