American Journal of Psychiatry
- Volume 179
- Number 7
- July 2022
Editor’s Note
Editorials
Reviews and Overviews
Publication date: 01 July 2022
Pages458–469Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a formidable treatment challenge across neuropsychiatric disorders. In major depressive disorder, anhedonia has been linked to poor disease course, worse response to ...
https://doi.org/10.1176/appi.ajp.20220423Articles
Publication date: 18 May 2022
Pages470–481Objective: Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of ...
https://doi.org/10.1176/appi.ajp.20081180Publication date: 12 April 2022
Pages482–489Objective: The authors evaluated AKL-T03, an investigational digital intervention delivered through a video game–based interface, designed to target the fronto-parietal network to enhance functional domains for attentional control. AKL-T03 was tested in ...
https://doi.org/10.1176/appi.ajp.21020125Publication date: 18 May 2022
Pages490–499Objective: Altered glutamatergic neurotransmission is implicated in the pathogenesis of major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA receptor antagonist and sigma-1 receptor agonist, which utilizes inhibition of CYP2D6 to ...
https://doi.org/10.1176/appi.ajp.21080800Publication date: 18 May 2022
Pages500–508Objective: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. Methods: Cross-sectional ...
https://doi.org/10.1176/appi.ajp.21050541Priority Data Letter
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