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American Journal of Psychiatry

  • Volume 179
  • Number 7
  • July 2022

Editor’s Note

Editorials

Reviews and Overviews

Publication date: 01 July 2022

Pages458–469

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a formidable treatment challenge across neuropsychiatric disorders. In major depressive disorder, anhedonia has been linked to poor disease course, worse response to ...

https://doi.org/10.1176/appi.ajp.20220423

Articles

Publication date: 12 April 2022

Pages482–489

Objective: The authors evaluated AKL-T03, an investigational digital intervention delivered through a video game–based interface, designed to target the fronto-parietal network to enhance functional domains for attentional control. AKL-T03 was tested in ...

https://doi.org/10.1176/appi.ajp.21020125

Publication date: 18 May 2022

Pages490–499

Objective: Altered glutamatergic neurotransmission is implicated in the pathogenesis of major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA receptor antagonist and sigma-1 receptor agonist, which utilizes inhibition of CYP2D6 to ...

https://doi.org/10.1176/appi.ajp.21080800

Publication date: 18 May 2022

Pages500–508

Objective: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. Methods: Cross-sectional ...

https://doi.org/10.1176/appi.ajp.21050541

Priority Data Letter

Past Issues

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No.11
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1 Nov 2024

Vol. 181 | No. 11

No.10
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1 Oct 2024

Vol. 181 | No. 10

No.9
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1 Sep 2024

Vol. 181 | No. 9

No.8
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1 Aug 2024

Vol. 181 | No. 8