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Published Online: 1 November 1998

Relationship of Cognitive and Functional Impairment to Depressive Features in Alzheimer's Disease and Other Dementias

Jennifer L. Payne, M.D., Constantine G. Lyketsos, M.D., M.H.S., Cynthia Steele, R.N., M.P.H., Lori Baker, B.A., Elizabeth Galik, R.N., M.S.N., Susan Kopunek, R.N., Martin Steinberg, M.D., and Andrew Warren, M.B.B.S.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 10, Number 4
https://doi.org/10.1176/jnp.10.4.440
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Abstract

Patients with clinical diagnoses of Alzheimer's disease, vascular dementia, or undifferentiated dementia were rated on standardized measures of depression, cognitive impairment, and functional impairment. Logistic regression was used to evaluate the relationship between functional or cognitive impairment, as well as their interaction, and depressive features in each group. This analysis revealed notable differences by type of dementia. The results imply that the mechanisms underlying depression in Alzheimer's disease may be different from those in vascular and other types of dementia. These results also provide indicators to the clinician for further evaluation of depression in different dementia subtypes.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 10 • Number 4 • November 1998
Pages: 440 - 447
PubMed: 9813790

History

Published online: 1 November 1998
Published in print: November 1998

Authors

Details

Jennifer L. Payne, M.D.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Constantine G. Lyketsos, M.D., M.H.S.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Cynthia Steele, R.N., M.P.H.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Lori Baker, B.A.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Elizabeth Galik, R.N., M.S.N.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Susan Kopunek, R.N.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Martin Steinberg, M.D.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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Andrew Warren, M.B.B.S.
Received December 3, 1996; revised May 1, 1997; accepted July 8, 1997. From the Neuropsychiatry and Memory Group, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, and Copper Ridge, Sykesville, Maryland. Address correspondence to Dr. Lyketsos, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21287.
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