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Published Online: 1 February 2000

Cognitive Correlates of the Negative, Disorganized, and Psychotic Symptom Dimensions of Schizophrenia

Daniel S. O'Leary, Ph.D., Michael Flaum, M.D., Marilyn L. Kesler, Laura A. Flashman, Ph.D., Stephan Arndt, Ph.D., and Nancy C. Andreasen, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 12, Number 1
https://doi.org/10.1176/jnp.12.1.4
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Abstract

Knowledge of the relationship between specific cognitive abnormalities and the clinical symptoms of schizophrenia could give insight into the nature of their underlying pathophysiology. Composite scores were generated for negative, disorganized, and psychotic symptom ratings in 134 patients with schizophrenia (DSM-IV criteria). Partial correlations (each composite corrected for the others) were computed with neuropsychological measures. Negative symptoms were related to poor performance on tests of verbal learning and memory, verbal fluency, visual memory, and visual-motor sequencing. Disorganized symptoms were correlated with lower verbal IQ and poor concept attainment. Psychotic symptoms had no significant relationship with cognitive deficit.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 12 • Number 1 • February 2000
Pages: 4 - 15
PubMed: 10678506

History

Published online: 1 February 2000
Published in print: February 2000

Authors

Affiliations

Daniel S. O'Leary, Ph.D.
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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Michael Flaum, M.D.
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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Marilyn L. Kesler
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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Laura A. Flashman, Ph.D.
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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Stephan Arndt, Ph.D.
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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Nancy C. Andreasen, M.D., Ph.D.
Received July 14, 1998; revised August 18, 1999; accepted October 1, 1999. From the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky; Dartmouth Hitchcock Medical School, Lebanon, New Hampshire; and Department of Preventive Medicine and Environmental Health, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa. Address correspondence to Dr. O'Leary, the Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa Hospitals and Clinics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242.
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