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Published Online: 1 November 2002

Clinical Features and Comorbidity of Mood Fluctuations in Parkinson's Disease

Brad A. Racette, M.D., Johanna M. Hartlein, R.N., B.S.N., Tamara Hershey, Ph.D., Jonathan W. Mink, M.D., Ph.D., Joel S. Perlmutter, M.D., and Kevin J. Black, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 14, Number 4
https://doi.org/10.1176/jnp.14.4.438
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Abstract

Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor “on” or “off” states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 14 • Number 4 • November 2002
Pages: 438 - 442
PubMed: 12426412

History

Published online: 1 November 2002
Published in print: November 2002

Authors

Details

Brad A. Racette, M.D.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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Johanna M. Hartlein, R.N., B.S.N.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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Tamara Hershey, Ph.D.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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Jonathan W. Mink, M.D., Ph.D.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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Joel S. Perlmutter, M.D.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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Kevin J. Black, M.D.
Received July 10, 2001; accepted September 18, 2001. From the Departments of Neurology & Neurological Surgery (b.a.r., j.w.m., j.s.p., k.j.b.), Anatomy & Neurobiology (j.w.m., j.s.p.), Pediatrics (j.w.m.), and Psychiatry (j.m.h., t.h., k.j.b.) and the Mallinckrodt Institute of Radiology (j.s.p., k.j.b.), Washington University School of Medicine, St. Louis, Missouri; and the American Parkinson Disease Association Advanced Center for Parkinson Research (all authors). Address correspondence to Dr. Racette, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110. E-mail: [email protected].
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