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Published Online: 1 February 2003

Cognitive and Motor Functioning in Gene Carriers for Huntington's Disease: A Baseline Study

Marie-Noëlle W. Witjes-Ané, M.Sc., Maria Vegter-van der Vlis, M.D., Jeroen P.P. van Vugt, M.D., Jan B.K. Lanser, Ph.D., Jo Hermans, Ph.D., Aeilko H. Zwinderman, Ph.D., Gert-Jan B. van Ommen, M.D., Ph.D., and Raymund A.C. Roos, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 15, Number 1
https://doi.org/10.1176/jnp.15.1.7
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Abstract

The aim of this study was to investigate the first changes in cognitive and motor functioning in Huntington's disease. Forty-six gene carriers, not clinically diagnosed for HD, were compared with 88 non–gene carriers. Gene carriers performed significantly worse on the Benton Visual Retention Test. This result was due to a minority of participants who had already developed cognitive impairment. Marginal differences appeared on the motor times of single reaction time measures after correction for motor signs. The findings are discussed in the context of inconsistencies in previous studies and underscore the need for longitudinal research.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 15 • Number 1 • February 2003
Pages: 7 - 16
PubMed: 12556566

History

Published online: 1 February 2003
Published in print: February 2003

Authors

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Marie-Noëlle W. Witjes-Ané, M.Sc.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Maria Vegter-van der Vlis, M.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Jeroen P.P. van Vugt, M.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Jan B.K. Lanser, Ph.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Jo Hermans, Ph.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Aeilko H. Zwinderman, Ph.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Gert-Jan B. van Ommen, M.D., Ph.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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Raymund A.C. Roos, M.D., Ph.D.
Received May 21, 2001; revised October 12, 2001; accepted December 14, 2001. From Leiden University Medical Center, Departments of Neurology, Clinical Genetics, Medical Statistics, and Human Genetics, Leiden; and the Department of Neuropsychology, Rijnland Hospital, Leiderdorp, the Netherlands. Address correspondence to M.N.W. Witjes-Ané, Leiden University Medical Center, Department of Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, the Netherlands. E-mail: [email protected]
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