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Published Online: 1 November 2004

Relationships Between Cognitive and Neurological Performance in Neuroleptic-Naïve Psychosis

Richard D. Sanders, M.D., Daniel Schuepbach, M.D., Gerald Goldstein, Ph.D., Gretchen L. Haas, Ph.D., John A. Sweeney, Ph.D., and Matcheri S. Keshavan, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 16, Number 4
https://doi.org/10.1176/jnp.16.4.480
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Abstract

The authors explored relationships between neuropsychological performance and neurological exam abnormalities in 86 never-medicated patients with nonorganic psychosis (59 with schizophrenia or schizoaffective disorder) and 51 healthy subjects. Assessments include a reliable subset of the Neurological Evaluation Scale (rNES) and several neuropsychological tests of attention, executive function, memory, and current and premorbid intelligence. Principal components analysis of the rNES yielded two main factors. Of these, CogPer (consisting of more cognitively demanding perceptual tasks) showed stronger relationships than RepMot (consisting of repetitive manual motor tasks) to neuropsychological measures. Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 16 • Number 4 • November 2004
Pages: 480 - 487
PubMed: 15616175

History

Published online: 1 November 2004
Published in print: November 2004

Authors

Affiliations

Richard D. Sanders, M.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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Daniel Schuepbach, M.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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Gerald Goldstein, Ph.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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Gretchen L. Haas, Ph.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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John A. Sweeney, Ph.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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Matcheri S. Keshavan, M.D.
Received May 23, 2002; revised November 5, 2002; accepted November 18, 2002. From the Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Sanders, Dayton VA, 116-M, 4100 West Third St., Dayton OH 45428; [email protected] (E-mail).
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