Conflict-of-Interest Charge

Another interesting strategy is the progesterone receptor antagonist mifepristone (RU 486), which at high concentrations is an effective antagonist of glucocorticoid action in vivo and in vitro (Lamberts et al. 1984; Proux-Ferland et al. 1982). Mifepristone has been observed to be useful in rapidly reversing psychotic depression secondary to Cushing’s syndrome (Nieman et al. 1985; Van Der Lely et al. 1991) and in patients with psychotic major depression (Belanoff et al. 2001; Rothschild and Belanoff 2000). Studies of mifepristone for the treatment of psychotic major depression using a double-blind, placebo-controlled paradigm are currently in progress at our center and several others across the country.