A Molecular Signature of Depression in the Amygdala
Abstract
Method
Subjects
Brain Samples
Microarray Samples
Microarray Quality Control
Rodent UCMS Model
White Matter/Gray Matter Analysis
Array Data Statistical Analysis
Selection of significant genes
Statistical criteria
Real-Time qPCR
Western Blot Analysis
Gene Coexpression Networks
Results
Amygdala-Anterior Cingulate Cortex Altered Gene Expression in Human Major Depression
Profiles of Altered Gene Transcripts Are Conserved Between Human Major Depression and the UCMS Mouse Model of Depression and Are Reversed by Antidepressant Treatments in Mice
Amygdala Cross-Species Correlations of Depression-Related Molecular Changes Identified a Subgroup of Human Major Depression Subjects
Two Distinct Oligodendrocyte and Neuronal Depression-Related Phenotypes in Amygdala
Genes With Conserved Major Depression- and UCMS-Related Changes Participate in a Highly Cohesive and Interactive Gene Coexpression Network
Discussion
A Phylogenetically Conserved Molecular Subtype of Depression in Amygdala
Oligodendrocyte and Principal Pyramidal Neuronal Changes in Amygdala in Depression
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