A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Sibling-Pair Sample for Linkage Analysis
Clinical Assessment
Sibling-Pair Blood Samples for Linkage Analysis
Sibling-Pair Linkage Analysis
Linkage Analysis Descriptive
Phenotype | ||||||
---|---|---|---|---|---|---|
Clinical Site | Number of Probands Ascertained | Age of Onset (Years) | Male (%) | Recurrent Depression | Severe Recurrent Depression | Very Severe Recurrent Depression |
St. Louis | 732 | 19.1 | 24.9 | 575 | 262 | 95 |
London | 233 | 21.1 | 24.5 | 222 | 170 | 84 |
Dublin | 274 | 22.3 | 32.8 | 262 | 195 | 113 |
Cardiff, United Kingdom | 248 | 24.9 | 25.8 | 232 | 162 | 96 |
Birmingham, United Kingdom | 303 | 24.0 | 31.4 | 295 | 232 | 143 |
Bonn, Germany | 276 | 29.8 | 25.4 | 260 | 249 | 238 |
Lausanne, Switzerland | 208 | 24.6 | 27.9 | 194 | 126 | 46 |
Aarhus, Denmark | 138 | 25.9 | 34.8 | 124 | 51 | 12 |
Total | 2,412 | 2,164 | 1,447 | 827 |
Phenotype | Total | Male (%) | Average Age of Onset (Years) |
---|---|---|---|
Recurrent depression | 2,164 | 26.12 | 22.6 |
Severe recurrent depression | 1,447 | 26.14 | 23.1 |
Very severe recurrent depression | 827 | 26.98 | 24.2 |
Samples for Case-Control Analysis
Genotyping for Case Patients and Comparison Subjects
Genotyping Workflow
Quality Control
Statistical Analysis
Results
Genome-Wide Linkage for Depression Phenotypes
Chromosome 3
Chromosome 7
Other Regions
Association Analyses
Discussion
Footnotes
Supplementary Material
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