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Abstract

Objective

Although anorexia nervosa has a high mortality rate, our understanding of the timing and predictors of mortality in eating disorders is limited. The authors investigated mortality in a long-term study of patients with eating disorders.

Method

Beginning in 1987, 246 treatment-seeking female patients with anorexia nervosa or bulimia nervosa were interviewed every 6 months for a median of 9.5 years to obtain weekly ratings of eating disorder symptoms, comorbidity, treatment participation, and psychosocial functioning. From January 2007 to December 2010 (median follow-up of 20 years), vital status was ascertained with a National Death Index search.

Results

Sixteen deaths (6.5%) were recorded (lifetime anorexia nervosa, N=14; bulimia nervosa with no history of anorexia nervosa, N=2). The standardized mortality ratio was 4.37 (95% CI=2.4–7.3) for lifetime anorexia nervosa and 2.33 (95% CI=0.3–8.4) for bulimia nervosa with no history of anorexia nervosa. Risk of premature death among patients with lifetime anorexia nervosa peaked within the first 10 years of follow-up, resulting in a standardized mortality ratio of 7.7 (95% CI=3.7–14.2). The standardized mortality ratio varied by duration of illness and was 3.2 (95% CI=0.9–8.3) for patients with lifetime anorexia nervosa for 0 to 15 years (4/119 died), and 6.6 (95% CI=3.2–12.1) for those with lifetime anorexia nervosa for >15 to 30 years (10/67 died). Multivariate predictors of mortality included alcohol abuse, low body mass index, and poor social adjustment.

Conclusions

These findings highlight the need for early identification and intervention and suggest that a long duration of illness, substance abuse, low weight, and poor psychosocial functioning raise the risk for mortality in anorexia nervosa.
Mortality rates are higher in anorexia nervosa than in other psychiatric disorders (1), but few studies have examined when death is more likely to occur in the course of this eating disorder. Most commonly, rates of premature death are described by the standardized mortality ratio, calculated as the number of observed deaths during a given period in a specific population of interest divided by the number of deaths expected in the general population, matched for age, race, and sex. A meta-analysis of 25 studies of patients with anorexia nervosa found a standardized mortality ratio of 5.9 in studies with a mean follow-up duration of 12.8 years (1). A similar standardized mortality ratio of 6.2 over 13.4 years of follow-up has also been reported (2). Although both are elevated, there was considerable variability in standardized mortality ratios across studies included in the meta-analysis (1), and these standardized mortality ratios are lower than those reported in studies with shorter follow-up periods (3, 4). Such variability across studies might be accounted for by ascertainment rates, sample size, severity of illness, and duration of follow-up, which may differ substantially from study to study. Thus, it would be instructive to examine the standardized mortality ratio in relation to the duration of follow-up as well as the duration of illness to understand whether there are high-risk periods for premature death in eating disorders.
Six longitudinal studies, including three in adolescents (57) and three in adults (810), have examined mortality rates over time. All of these investigations assessed anorexia nervosa patients at inpatient admission and again at multiple varying time points, ranging from 2 to 20 years after admission. Four of these studies found that the number of deaths increased with increasing duration of follow-up, with greater consistency in the adult studies than in the adolescent studies. However, it is unclear whether risk of death remained constant during follow-up because at least three studies (5, 9, 10) detected a majority of recorded deaths earlier in the follow-up period.
In the literature, it remains unknown at what point in the progression of the disorder death is more likely to occur and whether there are differences between patients with anorexia nervosa who die relatively early in the follow-up period (or early in the course of the disorder) and those who die later (after a more protracted or chronic course). These two variables, timing of follow-up assessment and duration of illness, are distinct; individuals with eating disorders do not necessarily seek treatment or enter a study at the exact point when they meet full diagnostic criteria. To clarify this distinction, our first aim in this longitudinal study was to examine standardized mortality ratios at two time points as well as at varying years of duration of illness. Such data might be informative as to whether there is a peak period for death in eating disorders. Our second aim was to examine factors that might increase vulnerability to premature death. Studies have indicated that older age at hospital admission, longer duration of eating disorder, history of attempted suicide, use of diuretics, more severe eating disorder symptoms, desire for lower weight at admission, repeated admission, and psychiatric comorbidity predict mortality (24, 11). We address the question of which variables predict mortality when examined at a later follow-up point in this longitudinal study. Predictor variables included eating disorder symptoms, comorbidity, treatment, and psychosocial functioning assessed both at intake and through interviews conducted over the study period.

Method

Participants

The sample consisted of females recruited for participation in the Massachusetts General Hospital Longitudinal Study of Anorexia and Bulimia Nervosa between 1987 and 1991. Most participants were seeking outpatient treatment for their eating disorder. Participants who met the following inclusion criteria were invited to participate: DSM-III-R diagnosis of anorexia nervosa or bulimia nervosa; female; age ≥12 years old; reside within 200 miles of Boston; English speaking; and no evidence of organic brain syndrome or terminal illness. Of the 294 individuals who met the study criteria, 250 (85%) agreed to participate; four dropped out after their intake interview, resulting in a sample size of 246. Participants were reclassified according to DSM-IV criteria, resulting in 51 with anorexia nervosa, restricting type, 85 with anorexia nervosa, binge eating/purging type, and 110 with bulimia nervosa. Of these, 186 (76%) were identified as having lifetime presence of anorexia nervosa, which was defined as 1) being diagnosed at study intake with anorexia nervosa (N=136), 2) having a history of anorexia nervosa prior to study intake (N=26), or 3) developing anorexia nervosa over the course of the study (N=24). Given our previous observations that individuals with lifetime anorexia nervosa who die continue to be at risk even when not actively ill and our previous analyses suggesting that deaths observed among individuals with intake diagnoses of bulimia nervosa might be attributable to a lifetime diagnosis of anorexia nervosa (11), we chose to analyze mortality by lifetime presence (not just intake diagnosis) of anorexia nervosa.

Procedure

This study was approved by the institutional review board at Massachusetts General Hospital. After brief telephone screening, individuals were scheduled for a face-to-face interview to confirm eating disorder diagnoses, assess other psychiatric disorders and treatment history, and measure height and weight. Follow-up interviews were conducted every 6 to 12 months until 2000.

Measures

During intake interviews, participants’ lifetime axis I psychiatric history was assessed using the Schedule for Affective Disorders and Schizophrenia–Lifetime Version (12), modified to include DSM-III-R diagnostic criteria for anorexia nervosa and bulimia nervosa. The 1983 Metropolitan Insurance Company (13) height and weight norms were used to calculate percent ideal body weight.
Over the course of the study, the Longitudinal Interval Follow-Up Evaluation, adapted for eating disorders (14), was used to assess eating pathology, treatment, and comorbid psychiatric disorders. Once a diagnosis was determined, the course of psychopathology was coded on a week-by-week basis using the Psychiatric Status Rating Scale (11), with scores ranging from 1 (no symptoms) to 6 (full diagnostic criteria). Major depressive disorder and substance use disorders were rated similarly.
Psychosocial functioning was assessed longitudinally using semistructured interviews to examine interpersonal relationships and functioning at work, in household chores, and in recreational activities, as well as global life satisfaction and overall functioning (15, 16). Ratings were made on a 5-point scale ranging from 1, no impairment, to 5, severe impairment. We refer to the global score measuring overall psychosocial functioning as the “social adjustment score.” The Global Assessment of Functioning Scale was used to evaluate overall level of symptom severity and impairment, with higher scores indicating better functioning. Further study details have been presented elsewhere (17).

Ascertainment of Vital Status

Vital status was ascertained in 2010 by searching the National Death Index (18). This index represents a branch of the National Center for Health Statistics with a national death certificate database updated through December 31, 2008, at the time of this investigation (19). Cause of death was obtained from death certificates, and, whenever possible, interviews were conducted with the deceased participant’s relatives to collect data concerning the participant immediately prior to her death.
The median time from study intake to last study visit was 9 years (range, 13 weeks–12 years), and the median time from last study visit to ascertainment of vital status was 11 years (range, 9 weeks–11 years), resulting in a median total follow-up time of 20 years (range, 13 weeks–23 years).

Statistical Data

To summarize mortality, we calculated crude mortality ratios, annual mortality rates (deaths per person-years), and standardized mortality ratios quantifying the excess number of deaths in our study population compared with what would be expected after adjusting for age, sex, and duration of follow-up. The expected number of deaths for a general white female population, adjusted for age, was derived from U.S. decennial life tables for Massachusetts from 1989 to 1991 (20). Fisher’s exact 95% confidence intervals around the standardized mortality ratios were calculated using chi-square centile cutoffs (21). We examined how risk of death changed over time by comparing the standardized mortality ratio by years of follow-up (0–10 years compared with >10–20 years) and by total duration of eating disorder (0–15 years compared with >15–30 years; from full-onset eating disorder through last study visit, excluding weeks with full eating disorder recovery). Formal comparison of the standardized mortality ratios by years of follow-up was not conducted because the ratios are not independent, and comparison by duration of illness is not recommended because our standardized mortality ratios were obtained by indirect standardization (because of the small number of deaths).
Cox proportional hazards regression was used to identify predictors of mortality. The proportional hazards assumption and functional form of the continuous covariates were verified using the methods of Lin et al. (22). Because mortality status was ascertained for many participants after the last study measurement of the course variables, use of time-varying covariates was not possible. Instead, we summarized the variability in course variables using mean scores for continuous covariates and percentage of weeks below or above a cutoff for ordinal or categorical covariates. All covariates analyzed are listed in Table 1.
TABLE 1. Summary of Covariates Analyzed for Female Patients With Lifetime Anorexia Nervosaa
VariableAlive (N=172)Died (N=14)b
 MeanSDMeanSD
Intake covariate    
Age (years) at eating disorder onset174.6175.9
Age (years) at study intake246.7307.7
Years of eating disorder prior to study intake75.7136.9
Body mass index (BMI)193.2163.4
Percent ideal body weight8414.07415.9
 N%N%
Eating disorder diagnosis    
 Anorexia nervosa, restricting type4426750
 Anorexia nervosa, binge eating/purging type7946643
 Bulimia nervosa492817
History of hospitalization for an eating disorder7745964
History of alcohol abuse2515429
History of drug use disorder1911429
History of bipolar disorder138214
Any suicidal gestures or attempts4928750
 MeanSDMeanSD
Course covariate    
Years from study intake to last visit92.063.1
Years from last visit to last follow-up or death121.734.2
Total years of eating disorder136.8177.0
Number of changes in eating disorder diagnosis22.011.6
Psychiatric Status Rating Scale    
 Anorexia nervosa score, percent of weeks ≥52332.75442.3
 Anorexia nervosa score, last visit2.31.94.31.8
Weight loss, percent of weeks ≥21%–29% below ideal body weight2032.65043.4
BMI, percent of 13-week periods <1625.8912.1
Last visit covariate    
BMI, last visit213.0173.9
Psychiatric Status Rating Scale    
 Alcohol abuse score, percent of weeks ≥326.61829.3
 Alcohol abuse score, last visit0.20.50.91.2
 Major depressive disorder score, percent of weeks ≥51219.52832.5
 Major depressive disorder score, last visit21.632.0
 Manic score, last visit0.10.40.30.8
Social adjustment ratingc    
 Average during study30.741.0
 Last visit30.941.1
Global Assessment of Functioning Scale score    
 Average during study569.04311.7
 Last visit5710.44212.2
a
Other course variables analyzed included the percent of study weeks meeting the following criteria: bulimia psychiatric status rating score ≥5 (percent of weeks dichotomized as above compared with at or below the median); binge eating/purging (including vomiting, laxative use, and diuretic use); other compensatory behavior (including diet pill use, fasting, and vigorous exercise); drug abuse psychiatric status rating score ≥3; hospitalized for an eating disorder; and suicidal gestures or attempts. Also analyzed were sessions of individual therapy received (mean over time) and marital status at last visit (single; married or living with a partner; or separated, divorced, or widowed).
b
A total of 16 patients died during the course of the study; two of the 16 had bulimia nervosa with no history of anorexia nervosa.
c
The ratings for social adjustment were as follows: 1=very good; 2=good; 3=fair; 4=poor; 5=very poor.
Univariate analyses were conducted first to ensure that relationships were not obscured by collinearity among the covariates; consistent with methods used previously (11), we conservatively applied a Bonferroni-corrected significance threshold of 0.0011, adjusting for the 46 individual comparisons made. Significant covariates were then entered into multivariate models, and stepwise variable selection (with alpha=0.01 to enter and alpha=0.05 to remain) was used to identify a final model. To facilitate comparison with cross-sectional studies that examined only intake covariates, we performed automated selection separately on variables measured at intake, over the course of the study, and at last study visit. All analyses were conducted using SAS, version 9.3 (SAS Institute, Cary, N.C.).

Results

Overall, 16 deaths (6.5%) were observed among the 246 participants (Table 2). Among the 186 individuals with a lifetime history of anorexia nervosa, 14 (7.5%) died, which translated to an annual mortality rate of 3.87 deaths per 1,000 person-years. After adjusting for age, sex, and race, the standardized mortality ratio for individuals with lifetime anorexia nervosa was 4.37 (95% exact confidence interval [CI]=2.4–7.3). Among the 60 participants with bulimia nervosa and no history of anorexia nervosa, two (3.3%) died, which translates to an annual mortality rate of 1.63 deaths per 1,000 person-years and a standardized mortality ratio of 2.33 (95% CI=0.3–8.4). When standardized mortality ratios were calculated by intake diagnosis rather than presence of lifetime anorexia nervosa, findings were consistent in that individuals with anorexia nervosa at intake had significantly elevated mortality (6.2 times the expected rate), while those with an intake diagnosis of bulimia nervosa did not (1.5 times the expected rate, with the confidence interval overlapping 1.0). Given the small number of deaths in the bulimia nervosa group, and the fact that the confidence interval for the standardized mortality ratio includes 1.0 (no elevated mortality), additional analyses focused primarily on participants with lifetime anorexia nervosa.
TABLE 2. Clinical Characteristics of 16 Women With an Eating Disorder Who Died During the Course of the Study
ParticipantEating Disorder Diagnosis at IntakeLifetime Anorexia NervosaAge at Intake (Years)Age at Death (Years)Years of Eating Disorder at IntakeTotal Years of Eating DisorderNumber of Changes in Eating Disorder DiagnosisPercent Below Ideal Body Weight at Last VisitYears From Intake to DeathYears From Last Visit to DeathCause of Death
1Anorexia nervosa, restricting typeYes393919.920.4030–390.80.4Suicide
2Anorexia nervosa, restricting typeYes324420.622.1021–2912.511.0Complications of resuscitated cardiac arrest; acute methadone, diazepam, and chloral hydrate intoxication
3Anorexia nervosa, restricting typeYes21290.95.76a6–98.20.7Suicide
4Anorexia nervosa, restricting typeYes43527.415.40≥409.11.1Respiratory failure due to amyotrophic lateral sclerosis
5Anorexia nervosa, restricting typeYes29369.717.0010–147.70.5Suicide
6Anorexia nervosa, restricting typeYes264311.019.5021–2917.18.7Gastrointestinal hemorrhage, esophageal ulceration
7Anorexia nervosa, restricting typeYes304813.221.5010–1418.09.7Anoxic brain injury, septic shock
8Anorexia nervosa, binge eating/purging typeYes293815.323.6210–149.10.9Fungal pneumonia
9Anorexia nervosa, binge eating/purging typeYes20248.110.616–94.92.4Cardiac arrhythmia, seizure disorder
10Anorexia nervosa, binge eating/purging typeYes434524.927.2221–292.40.2Acute ethanol intoxication
11Anorexia nervosa, binge eating/purging typeYes303912.914.02a10–149.80.3Cardiopulmonary arrest, cardiovascular disease, diabetes mellitus
12Anorexia nervosa, binge eating/purging typeYes303516.820.11≥405.32.0Suicide
13Anorexia nervosa, binge eating/purging typeYes333817.622.91≥405.80.5Cardiorespiratory failure, hepatic failure, cirrhosis
14Bulimia nervosaYes18352.52.51b6–917.39.1Chronic ethanol abuse with early cirrhosis of liver
15Bulimia nervosaNo20350.910.206–915.26.0Acute bronchopneumonia; cerebral glioma
16Bulimia nervosaNo304020.229.706–910.51.0Mitral valve prolapse
a
Participant recovered from eating disorder during follow-up but subsequently relapsed.
b
Participant had recovered from eating disorder by the time of her last study visit.
Of the 16 deaths, four occurred by suicide (all four of these patients had anorexia nervosa). We previously reported the standardized mortality ratio for suicide in our sample to be 56.9 (11). With no new completed suicides in the sample, but an increased number of expected suicides in the demographically matched population since our last analysis, the standardized mortality ratio for suicide among individuals with lifetime anorexia in this sample is now substantially lower, calculated to be 25.2 [95% CI=6.9–64.5].
Risk of premature mortality appeared to decrease over time among individuals with lifetime anorexia nervosa. Within the first 10 years of follow-up, the annual mortality rate for this group was 5.49 deaths per 1,000 person-years, compared with 1.13 deaths per 1,000 person-years thereafter. The standardized mortality ratio also varied substantially by follow-up time. For the follow-up duration from 0 to 10 years (10/186 died), the standardized mortality ratio was 7.7 (95% CI=3.7–14.2), and for the follow-up duration >10 to 20 years (4/176 died), the ratio was 0.7 (95% CI=0.2–1.7). When we examined the standardized mortality ratio by illness duration, we again found considerable variation. The standardized mortality ratio for those with an eating disorder for 0 to 15 years (4/119 died) was 3.2 (95% CI=0.9–8.3), and for those with an eating disorder lasting >15 to 30 years (10/67 died), the ratio was 6.6 (95% CI=3.2–12.1). In other words, the standardized mortality ratio was higher within the first decade of the study compared with the second decade and for those with a longer duration of illness. Specifically, seven of the 10 patients with a longer duration of illness died in the first decade of the study (Table 2), although three of the four patients who died in the second decade also had a longer duration of illness. Thus, the 10 patients who died in the first decade were not the same 10 patients with >15 years of an eating disorder, suggesting that these covariates capture somewhat different information.
The number of changes in eating disorder diagnosis over the course of the study is presented in Table 2. Our previous work indicated that over time, the majority of patients with an intake diagnosis of anorexia nervosa in the entire sample experienced crossover between the anorexia nervosa subtypes or from anorexia nervosa to bulimia nervosa; crossover was recurrent and bidirectional with the subtypes (23, 24). In contrast, crossover from bulimia nervosa to anorexia nervosa in individuals without a history of anorexia nervosa at intake was less common (23). It is noteworthy that two of the three individuals with an intake diagnosis of bulimia nervosa who died did not meet criteria for anorexia nervosa during the course of follow-up, nor did they have a history of anorexia nervosa at intake. It is possible that associations between mortality and eating disorder diagnoses depend on when in the course of illness diagnostic status is assessed. Importantly, however, an examination of diagnostic crossover in our predictor analyses indicated that it was not a significant predictor of mortality.
Values of covariates ascertained at intake and course variables examined as predictors of mortality are summarized in Table 1. Although the mean age at eating disorder onset was similar between participants who were still alive at last follow-up and those who died prematurely, those who were still alive at last follow-up entered the study at a much earlier age than those who died prematurely, indicating that those who died had a longer duration of illness prior to study intake, which may reflect delays between disorder onset and seeking treatment.
As shown in the survival curve (Figure 1), whereas individuals without lifetime anorexia nervosa were more likely to die later in the study, most deaths among those with lifetime anorexia nervosa occurred at varying times within the first 10 years of follow-up. Furthermore, while lifetime anorexia nervosa appeared to confer greater risk of mortality, the overall mortality rate was still low in both groups (survival at 20 years after study intake among individuals with and without lifetime anorexia nervosa was 92% and 97%, respectively).
FIGURE 1. Survival Curve Comparing Female Patients With and Without a Lifetime History of Anorexia Nervosa
Significant univariate predictors (before and after Bonferroni correction) are presented in Table 3. After applying automated model selection separately to the significant intake, course, and last visit variables, duration of illness was the only significant intake variable to predict mortality. Among course variables, percent of weeks with alcohol abuse and percent of weeks with low body mass index (BMI) (<16) remained in the model. Among last visit covariates, alcohol abuse, BMI, and social adjustment score remained significant. To determine which of the intake, course, and last visit variables together best predicted mortality, we conducted one final automated stepwise selection, which resulted in three variables remaining significant: percent of weeks with alcohol abuse, BMI at last visit, and social adjustment score at last visit. Finally, to account for the fact that, by definition, the last study visit was closer to the time of death than to the time of the last follow-up for those still alive, we forced age at intake into the final model to account for the passage of calendar time. Both the significance and the direction of effect of the covariates were maintained in the final model after adjusting for age.
TABLE 3. Significant Univariate Predictors of Mortality Among Female Patients With Lifetime Anorexia Nervosa
Univariate PredictorTime PointEstimateStandard ErrorHazard Ratio95% CIp
Age (years)Intake0.100.0311.681.2–2.3a0.0009**
Eating disorder diagnosisLast visit 0.04*
Eating disorder diagnosisLast visit (bulimia nervosa compared with anorexia nervosa, restricting type)−2.151.0490.120.02–0.90.04*
Eating disorder diagnosis, last visitLast visit (full eating disorder recovery compared with anorexia nervosa, restricting type)−2.381.0490.0920.01–0.70.02*
Years of eating disorderIntake0.130.0361.941.4–2.8a0.0002**
Years of eating disorderTotal0.0780.0341.471.0–2.1a0.03*
Anorexia nervosa Psychiatric Status Rating Scale scorePercent of weeks ≥50.0200.00651.221.1–1.4b0.002*
Anorexia nervosa Psychiatric Status Rating Scale scoreLast visit0.640.201.891.3–2.80.002*
Bulimia nervosa Psychiatric Status Rating Scale scorePercent of weeks ≥5–above compared with at or below median (6.5%)−1.330. 650.270.1–0.9b0.04*
Percent ideal body weightIntake−5.682.170.570.4–0.9b0.009*
Weight lossPercent of weeks ≥21%–29% below ideal body weight0.0190.00631.211.1–1.4b0.003*
Weight lossLast visit 0.04*
Weight lossLast visit; 6%–9% compared with 21%–29% below ideal body weight−2.010.690.130.0–0.50.004*
BMIIntake−0.290.100.750.6–0.90.005*
BMIPercent of 13-week periods <160.0770.0222.151.4–3.3b0.0004**
BMILast visit−0.390.0840.680.6–0.8b<0.0001**
Alcohol abuse Psychiatric Status Rating Scale scorePercent of weeks ≥30.0480.00961.611.3–1.9b<0.0001**
Alcohol abuse Psychiatric Status Rating Scale scoreLast visit0.940.242.551.6–4.1<0.0001**
Major depressive disorder Psychiatric Status Rating Scale scorePercent of weeks ≥50.0210.00821.231.0–1.4b0.01*
Major depressive disorder Psychiatric Status Rating Scale scoreLast visit0.440.141.561.2–2.00.001*
Social adjustment scoreAverage during study1.410.314.102.2–7.5<0.0001**
Social adjustment scoreLast visit1.290.273.642.21–6.2<0.0001**
Global Assessment of Functioning Scale scoreAverage during study−0.110.0270.320.2–0.5b<0.0001**
Global Assessment of Functioning Scale scoreLast visit−0.110.0230.340.2–0.5b<0.0001**
a
The hazard ratio is calculated for a 5-year increase in the covariate.
b
The hazard ratio is calculated for a 10-unit increase in the covariate.
* Indicates significance at an alpha level of 0.05; ** indicates significance at a Bonferroni-corrected alpha level of 0.0011.
To understand the factors captured by the social adjustment score, we compared social adjustment components at last visit by mortality status. Women who died had moderate to severe impairment in employment (t=–4.92, df=160, p<0.0001), mild to moderate impairment in household functioning (t=–4.24, df=174, p<0.0001), and fair to poor interpersonal relationships with friends (t=–2.96, df=184, p=0.003) and siblings (t=–2.35, df=184, p=0.02) and were more likely to be single (Fisher’s exact p=0.07). They also had fair to poor enjoyment of recreational activities (t=–3.00, df=184, p=0.003) and low global satisfaction (t=–2.88, df=184, p=0.004). There were no significant differences in interpersonal relationships with partners or with parents.

Discussion

Our analyses revealed that patients with lifetime anorexia nervosa had higher premature mortality rates than the general population and that risk of premature death was highest in the first 10 years of follow-up and among individuals with the longest duration of illness. This finding may be explained by the fact that most of the women who died came into the study with a long duration of illness. With one exception, those who died reported an illness duration spanning 7 to 25 years before entry into the study. It may be that their deaths tended to come early in the study because they had already suffered a long period of time with an eating disorder. Thus, while mortality rates in anorexia nervosa varied based on when in the course of this longitudinal study mortality was assessed as well as by the duration of the disorder, it seems likely that chronicity is a crucial factor in premature death.
In some (25) but not all (26, 27) studies, the standardized mortality ratio for bulimia nervosa has been reported to be lower than that for anorexia nervosa. Interestingly, however, two of the three women with bulimia nervosa in our study who died had never been diagnosed with anorexia nervosa. Future research might investigate causes of death in bulimia nervosa, as well as potential predictors, by combining data sets in order to achieve adequate sample sizes.
The age and cause of death in this sample of patients with anorexia nervosa are noteworthy. All deaths occurred in middle adulthood, with all but three deaths occurring between ages 35 and 48 years, suggesting that for women with long-standing histories of eating disorders, middle adulthood is a particularly high-risk period for dying. Furthermore, the causes of death, with a few exceptions (e.g., amyotrophic lateral sclerosis), may have been related to eating disorder symptoms, although given the time lapse between the last interview and death, we are not able to address this issue definitively. In the case of the four suicides, the causes of death represent extreme methods with high lethality (28).
Although a number of predictor variables were significant in univariate analyses, alcohol abuse over the course of the study and BMI and social adjustment at the last interview remained significant in multivariate analyses. Our earlier analyses at the 10-year follow-up found that longer duration of illness at intake and severity of alcohol use disorder during follow-up increased the risk of mortality (11). Over the longer follow-up period, the degree of low weight and the social adjustment score at the last visit also emerged as significant multivariate predictors of mortality.
Social adjustment has been linked to mortality in depression and substance abuse (29, 30). While it is difficult to know in what ways poor social adjustment may be related to mortality (i.e., directly, in concert with comorbidity, or as a reflection of eating disorder severity), our findings indicate that assessing the quality of relationships, the capacity for work and play, and the degree of impairment in psychosocial functioning is vital when working with patients with anorexia nervosa. Recent efforts examining the care of individuals with long-term anorexia nervosa are important, given how little is known about how to treat patients with a chronic eating disorder (31, 32).
Strengths of our study include the large well-maintained sample, the long duration of follow-up, and the careful assessment of diagnoses. Limitations include that the assessment of comorbidity was limited to substance abuse and depression and that no longitudinal data were available between the last study visit and the assessment of mortality, which constituted a lengthy period in some cases. Thus, it is possible that mortality was affected by unobserved life events that occurred between the last study visit and death. Furthermore, the National Death Index does not report deaths that occur outside the United States.
In conclusion, anorexia nervosa continues to be a disorder with high mortality rates and one for which effective treatment remains elusive (33). Our findings highlight the need for early identification and intervention and suggest that among those with a long duration of illness, particularly when substance abuse, low weight, or poor psychosocial functioning are also present, the risk for mortality increases substantially.

References

1.
Arcelus J, Mitchell A, Wales J, Nielsen S: Is there an elevated mortality rate in anorexia nervosa and other eating disorders? a meta-analysis of 36 studies. Arch Gen Psychiatry 2011; 68:724–731
2.
Papadopoulos FC, Ekbom A, Brandt L, Ekselius L: Excess mortality, causes of death and prognostic factors in anorexia nervosa. Br J Psychiatry 2009; 194:10–17
3.
Button EJ, Chadalavada B, Palmer RL: Mortality and predictors of death in a cohort of patients presenting to an eating disorders service. Int J Eat Disord 2010; 43:387–392
4.
Huas C, Caille A, Godart N, Foulon C, Pham-Scottez A, Divac S, Dechartres A, Lavoisy G, Guelfi JD, Rouillon F, Falissard B: Factors predictive of ten-year mortality in severe anorexia nervosa patients. Acta Psychiatr Scand 2011; 123:62–70
5.
Steinhausen HC, Seidel R, Winkler Metzke C: Evaluation of treatment and intermediate and long-term outcome of adolescent eating disorders. Psychol Med 2000; 30:1089–1098
6.
Herpertz-Dahlmann B, Müller B, Herpertz S, Heussen N, Hebebrand J, Remschmidt H: Prospective 10-year follow-up in adolescent anorexia nervosa: course, outcome, psychiatric comorbidity, and psychosocial adaptation. J Child Psychol Psychiatry 2001; 42:603–612
7.
Strober M, Freeman R, Morrell W: The long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study. Int J Eat Disord 1997; 22:339–360
8.
Ratnasuriya RH, Eisler I, Szmukler GI, Russell GF: Anorexia nervosa: outcome and prognostic factors after 20 years. Br J Psychiatry 1991; 158:495–502
9.
Löwe B, Zipfel S, Buchholz C, Dupont Y, Reas DL, Herzog W: Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study. Psychol Med 2001; 31:881–890
10.
Fichter MM, Quadflieg N, Hedlund S: Twelve-year course and outcome predictors of anorexia nervosa. Int J Eat Disord 2006; 39:87–100
11.
Keel PK, Dorer DJ, Eddy KT, Franko D, Charatan DL, Herzog DB: Predictors of mortality in eating disorders. Arch Gen Psychiatry 2003; 60:179–183
12.
Spitzer RL, Endicott J: Schedule for Affective Disorders and Schizophrenia (SADS), 3rd ed. New York, New York State Psychiatric Institute, Biometrics Research, 1979
13.
Metropolitan Life Insurance Company: 1983 metropolitan height and weight tables. Stat Bull Metrop Life Found 1983; 64:3–9
14.
Keller MB, Lavori PW, Friedman B, Nielsen E, Endicott J, McDonald-Scott P, Andreasen NC: The Longitudinal Interval Follow-up Evaluation: a comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987; 44:540–548
15.
Leon AC, Solomon DA, Mueller TI, Turvey CL, Endicott J, Keller MB: The Range of Impaired Functioning Tool (LIFE-RIFT): a brief measure of functional impairment. Psychol Med 1999; 29:869–878
16.
Leon AC, Solomon DA, Mueller TI, Endicott J, Posternak M, Judd LL, Schettler PJ, Akiskal HS, Keller MB: A brief assessment of psychosocial functioning of subjects with bipolar I disorder: the LIFE-RIFT. Longitudinal Interval Follow-up Evaluation-Range Impaired Functioning Tool. J Nerv Ment Dis 2000; 188:805–812
17.
Herzog DB, Dorer DJ, Keel PK, Selwyn SE, Ekeblad ER, Flores AT, Greenwood DN, Burwell RA, Keller MB: Recovery and relapse in anorexia and bulimia nervosa: a 7.5-year follow-up study. J Am Acad Child Adolesc Psychiatry 1999; 38:829–837
18.
Horm J: National Death Index User’s Manual, Appendix A: Assignment of Probabilistic Scores to National Death Index Record Matches. Hyattsville, Md, National Center for Health Statistics, 1996
19.
Calle EE, Terrell DD: Utility of the National Death Index for ascertainment of mortality among cancer prevention study II participants. Am J Epidemiol 1993; 137:235–241
20.
National Center for Health Statistics: U.S. Decennial Life Tables for 1989–91, vol 2, State Life Tables, No 22, Massachusetts. Hyattsville, Md, National Center for Health Statistics, 1998
21.
Ulm K: A simple method to calculate the confidence interval of a standardized mortality ratio (SMR). Am J Epidemiol 1990; 131:373–375
22.
Lin D, Wei LJ, Ying Z: Checking the cox model with cumulative sums of martingale-based residuals. Biometrika 1993; 80:557–572
23.
Eddy KT, Dorer DJ, Franko DL, Tahilani K, Thompson-Brenner H, Herzog DB: Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V. Am J Psychiatry 2008; 165:245–250
24.
Eddy KT, Swanson SA, Crosby RD, Franko DL, Engel S, Herzog DB: How should DSM-V classify eating disorder not otherwise specified (EDNOS) presentations in women with lifetime anorexia or bulimia nervosa? Psychol Med 2010; 40:1735–1744
25.
Smink FRE, van Hoeken D, Hoek HW: Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep 2012; 14:406–414
26.
Crow SJ, Peterson CB, Swanson SA, Raymond NC, Specker S, Eckert ED, Mitchell JE: Increased mortality in bulimia nervosa and other eating disorders. Am J Psychiatry 2009; 166:1342–1346
27.
Crow SJ, Swanson SA, Peterson CB, Crosby RD, Wonderlich SA, Mitchell JE: Latent class analysis of eating disorders: relationship to mortality. J Abnorm Psychol 2012; 121:225–231
28.
Holm-Denoma JM, Witte TK, Gordon KH, Herzog DB, Franko DL, Fichter M, Quadflieg N, Joiner TE: Deaths by suicide among individuals with anorexia as arbiters between competing explanations of the anorexia-suicide link. J Affect Disord 2008; 107:231–236
29.
Feigelman W, Gorman BS: Prospective predictors of premature death: evidence from the National Longitudinal Study of Adolescent Health. J Psychoactive Drugs 2010; 42:353–361
30.
Holwerda TJ, Beekman AT, Deeg DJ, Stek ML, van Tilburg TG, Visser PJ, Schmand B, Jonker C, Schoevers RA: Increased risk of mortality associated with social isolation in older men: only when feeling lonely? results from the Amsterdam Study of the Elderly (AMSTEL). Psychol Med 2012; 42:843–853
31.
Bamford BH, Mountford VA: Cognitive behavioural therapy for individuals with longstanding anorexia nervosa: adaptations, clinician survival and system issues. Eur Eat Disord Rev 2012; 20:49–59
32.
Wonderlich S, Mitchell JE, Crosby RD, Myers TC, Kadlec K, Lahaise K, Swan-Kremeier L, Dokken J, Lange M, Dinkel J, Jorgensen M, Schander L: Minimizing and treating chronicity in the eating disorders: a clinical overview. Int J Eat Disord 2012; 45:467–475
33.
Keel PK, Brown TA: Update on course and outcome in eating disorders. Int J Eat Disord 2010; 43:195–204

Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 917 - 925
PubMed: 23771148

History

Received: 2 July 2012
Revision received: 24 October 2012
Revision received: 1 November 2012
Revision received: 7 December 2012
Accepted: 3 January 2013
Published online: 1 August 2013
Published in print: August 2013

Authors

Details

Debra L. Franko, Ph.D.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
Aparna Keshaviah, Sc.M.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
Kamryn T. Eddy, Ph.D.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
Meera Krishna, B.A.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
Martha C. Davis, B.A.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
Pamela K. Keel, Ph.D.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.
David B. Herzog, M.D.
From the Harris Center for Education and Advocacy in Eating Disorders and the Department of Psychiatry, Massachusetts General Hospital, Boston; Department of Counseling and Applied Educational Psychology, Northeastern University, Boston; and Department of Psychology, Florida State University, Tallahassee, Fla.

Notes

Presented in part at the 2012 International Conference on Eating Disorders, Austin, Tex., May 3–5, 2012.
Address correspondence to Dr. Franko ([email protected]).

Funding Information

The authors report no financial relationships with commercial interests.Supported by NIMH grants R01 MH-38333 (to Dr. Herzog) and R03 MH-094832 (to Drs. Eddy and Herzog).

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