Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Samples
Image Acquisition and Processing
Statistical Analysis
Results
Characteristic | Adult OCD Patients (N=1,498) | Adult Healthy Controls (N=1,436) | Pediatric OCD Patients (N=407) | Pediatric Healthy Controls (N=324) | ||||
---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
Age (years) | 32.1a | 9.7 | 30.5a | 9.7 | 13.8 | 2.5 | 13.6 | 2.6 |
OCD illness severity scoreb | 24.4 | 6.9 | 21.4 | 7.3 | ||||
Age at onset of clinical symptoms (years) | 19.8 | 9.1 | 10.6 | 3.1 | ||||
N | % | N | % | N | % | N | % | |
Male | 756 | 50.5 | 713 | 49.7 | 220 | 54.1 | 164 | 50.6 |
Medication use at time of scan | 646 | 43.1 | 183 | 45.0 | ||||
Current comorbid disorders | ||||||||
Anxiety disorder | 224 | 15.0 | 132 | 32.4 | ||||
Major depression | 167 | 11.1 | 29 | 7.1 | ||||
Tourette’s disorderc | 24 | 1.6 | 30 | 7.4 | ||||
Attention deficit hyperactivity disorderc | 13 | 0.9 | 42 | 10.3 | ||||
Autism spectrum disorderc | 0 | 0.0 | 5 | 1.2 | ||||
OCD symptom dimensionsd | ||||||||
Aggressive/checking | 927 | 61.9 | 195 | 47.9 | ||||
Contamination/cleaning | 791 | 52.8 | 172 | 42.3 | ||||
Symmetry/ordering | 640 | 42.7 | 181 | 44.5 | ||||
Sexual/religious | 487 | 32.5 | 92 | 22.6 | ||||
Hoarding | 379 | 25.3 | 92 | 22.6 |
Mega-Analysis
Cortical thickness and surface area differences between OCD patients and controls.
Adults:
Children:
Influence of medication on cortical thickness and surface area.
Adults:
Children:
Influence of comorbidities on cortical thickness and surface area.
Influence of symptom dimensions on cortical thickness and surface area.
Adults:
Children:
Influence of age at onset and illness duration on cortical thickness and surface area.
Association between illness severity and cortical thickness and surface area.
Meta-Analysis
Discussion
Cortical Thickness
Surface Area
Limitations
Conclusions
Acknowledgments
Supplementary Material
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