Polygenic Risk and Progression to Bipolar or Psychotic Disorders Among Individuals Diagnosed With Unipolar Depression in Early Life
Abstract
Objective:
Methods:
Results:
Conclusions:
Methods
Data Sources
Genotyping
Study Sample
Measures
Analysis
Sensitivity Analysis
Results
Sample Characteristics
Characteristic | N | % |
---|---|---|
Sex | ||
Female | 11,675 | 68.9 |
Male | 5,274 | 31.1 |
Treatment setting | ||
Outpatient | 10,390 | 61.3 |
Inpatient | 2,495 | 14.7 |
Emergency department | 4,064 | 24.0 |
ICD-10 diagnostic code | ||
F32 | 13,655 | 80.6 |
F33 | 3,294 | 19.4 |
Severity | ||
Mild | 2,969 | 17.5 |
Moderate | 7,484 | 44.2 |
Severe | 1,584 | 9.3 |
Psychotic | 441 | 2.6 |
Unspecified | 4,471 | 26.4 |
Diagnosis type | ||
Main | 14,167 | 83.6 |
Secondary | 2,773 | 16.4 |
Underlying cause | 9 | 0.1 |
Age at diagnosis (years) | ||
10–18 | 7,041 | 41.5 |
19–24 | 6,562 | 38.7 |
25–29 | 3,241 | 19.1 |
30–35 | 105 | 0.6 |
Parental history of mental disorders | ||
Unipolar depression | 1,468 | 8.7 |
Bipolar disorder | 191 | 1.1 |
Psychotic disorder | 498 | 2.9 |
Main Outcomes
Secondary Outcomes
PRS and Parental History
Absolute Risk of Progression by Parental History and Polygenic Liability
Sensitivity Analysis
Discussion
Limitations
Footnote
Supplementary Material
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