Reversible Mirror Clock Drawing After Acute Right Frontoparietal Lobe Infarct

A 30-year-old right-handed woman experienced acute onset left hemiparesis and visuospatial problems during her first experience with scuba diving. Before this event, she worked as an illustrator of three-dimensional computer graphics and was generally healthy, except that she had experienced two episodes of transient left arm numbness and weakness while under acute emotional stress: the first event occurred when she was 6 years old, and the other occurred when she was 12 years old. The left hemiparesis developed within 30 minutes after the scuba diving, with some fluctuation for the following 3 days. Meanwhile, she got lost in the Mass Rapid Transit station, lost her ability to touch type, and became unable to find the toolbox in the computer graphics program she used for her work. On admission to our Stroke Center on the third day after onset, the patient manifested left central–type facial palsy, left hemiparesis, left hypesthesia, and left-sided unilateral spatial neglect. Interestingly, mirror clock drawing (Figure 1, panel A) in addition to the unilateral spatial neglect (Figure 1, panel B) was noted, whereas spatial orientation was preserved on her handwriting and picture copying (Figure 1, panels C and D). Brain MRI scans showed recent infarcts in the right frontoparietal subcortical regions (Figure 2, panels A and B) and small cortical areas (Figure 2, panel C). MR angiography and further conventional angiography revealed bilateral steno-occlusive middle cerebral arteries with formation of multiple tiny collateral vessels, indicating moyamoya disease. Her clock drawing became normalized at 3 weeks after stroke onset, along with improvements in the left hemiparesis and spatial neglect.

Visuospatial disorientation has long been associated with right hemispheric lesions, especially in the right parietal lobe.^1,2 It commonly presents as hemispatial neglect, spatial disorientation, constructional apraxia, or impairments of topographic memory.³ In our patient, the hemispatial neglect could be demonstrated by the line cancellation test. The patient's history of getting lost in a familiar place and the inability to perform her regular computer graphics program suggested impairment in topographic memory. Importantly, the patient demonstrated a consistent mirror clock drawing with intact abilities of picture copying and writing words during the acute stroke stage. The reversibility of her visuospatial symptoms in the subacute phase suggested a direct link with the acute ischemic process rather than underlying moyamoya disease.

The discrepancy between free clock drawing and picture copying indicated a specific deficit in visuospatial memory, with preserved spatial perceptual and remapping functions. To the best of our knowledge, our patient is the first to demonstrate the particular mirror clock drawing after a right hemispheric infarct, which provides novel insight about the delicate and complicated processes involved in visuospatial perception, recall, and remapping.