American Journal of Psychiatry

Objective: In this review, the authors update the 2018 report of the American Psychiatric Association Council of Research Workgroup on Biomarkers and Novel Treatments on pharmacogenomic (PGx) tools for treatment selection in depression. Methods: The ...

https://doi.org/10.1176/appi.ajp.20230657

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Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits

Publication date: 15 May 2024

Pages608–619

Objective: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability ...

https://doi.org/10.1176/appi.ajp.20230247

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Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder

Publication date: 11 June 2024

Pages620–629

Objective: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known ...

https://doi.org/10.1176/appi.ajp.20230073

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A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression

Publication date: 01 July 2024

Pages630–638

Objective: Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk ...

https://doi.org/10.1176/appi.ajp.20230477

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Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects

Publication date: 30 April 2024

Pages639–650

Objective: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address ...

https://doi.org/10.1176/appi.ajp.20230382

Associations Between General and Specific Mental Health Conditions in Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A 40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish Individuals

Publication date: 24 January 2024

Pages651–657

Objective: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured ...

https://doi.org/10.1176/appi.ajp.20220951