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Published Online: 1 August 2002

Subcortical Hyperintensities in Alzheimer's Disease: Associated Clinical and Metabolic Findings

David L. Sultzer, M.D., Stephen T. Chen, M.D., Charles V. Brown, M.D., Michael E. Mahler, M.D., Jeffrey L. Cummings, M.D., Charles H. Hinkin, Ph.D., and Mark A. Mandelkern, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 14, Number 3
https://doi.org/10.1176/jnp.14.3.262
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Abstract

The authors measured subcortical hyperintensities (SH) on magnetic resonance images (MRI) in 18 patients with probable Alzheimer's disease and examined the relationships of SH severity with cortical metabolic function and clinical symptoms. Severity of SH was not correlated with absolute metabolic rates in cortical lobes. However, anterior SH severity was inversely correlated with frontal/ parietal metabolic ratios after covarying for cognitive impairment. SH severity in some areas was associated with the severity of global neuropsychiatric symptoms, but marked effects on individual symptoms were not apparent. The small sample size and multiple variables limit conclusions that can be drawn. These preliminary findings indicate that subcortical MRI hyperintensities may play a role in the pathophysiology and clinical expression of Alzheimer's disease.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 14 • Number 3 • August 2002
Pages: 262 - 269
PubMed: 12154149

History

Published online: 1 August 2002
Published in print: August 2002

Authors

Details

David L. Sultzer, M.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Stephen T. Chen, M.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Charles V. Brown, M.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Michael E. Mahler, M.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Jeffrey L. Cummings, M.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Charles H. Hinkin, Ph.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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Mark A. Mandelkern, M.D., Ph.D.
Received August 21, 2001; revised January 15, 2002; accepted January 25, 2002. From the Departments of Psychiatry and Biobehavioral Sciences (s.t.c., j.l.c., c.h.h., d.l.s.) and Neurology (j.l.c., m.e.m.), University of California-Los Angeles; and Psychiatry (s.t.c., m.e.m., d.l.s.), Psychology (c.h.h.), and Nuclear Medicine Services (c.v.b., m.a.m.), Veterans Affairs Greater Los Angeles Healthcare System. The views expressed are those of the authors and do not necessarily represent those of the Department of Veterans Affairs. Address correspondence to Dr. Sultzer, Psychiatry, 3South, 116AF, West Los Angeles VA Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073. E-mail: [email protected].
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