American Journal of Psychiatry

Objective: Childhood maltreatment is associated with mental health problems, but the extent to which this relationship is causal remains unclear. To strengthen causal inference, the authors conducted a systematic review and meta-analysis of quasi-...

https://doi.org/10.1176/appi.ajp.20220174

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Racial Disparities in Adversity During Childhood and the False Appearance of Race-Related Differences in Brain Structure

Publication date: 01 February 2023

Pages127–138

Objective: Black Americans in the United States are disproportionately exposed to childhood adversity compared with White Americans. Such disparities may contribute to race-related differences in brain structures involved in regulating the emotional ...

https://doi.org/10.1176/appi.ajp.21090961

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Polygenic Risk and Social Support in Predicting Depression Under Stress

Publication date: 11 January 2023

Pages139–145

Objective: Despite substantial progress in identifying genomic variation associated with major depression, the mechanisms by which genomic and environmental factors jointly influence depression risk remain unclear. Genomically conferred sensitivity to the ...

https://doi.org/10.1176/appi.ajp.21111100

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Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

Publication date: 11 January 2023

Pages146–154

Objective: The weak link between subjective symptom-based diagnostic methods for posttraumatic psychopathology and objectively measured neurobiological indices forms a barrier to the development of effective personalized treatments. To overcome this ...

https://doi.org/10.1176/appi.ajp.20220271

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Project Harmony: A Meta-Analysis With Individual Patient Data on Behavioral and Pharmacologic Trials for Comorbid Posttraumatic Stress and Alcohol or Other Drug Use Disorders

Publication date: 07 December 2022

Pages155–166

Objective: Treatment efficacy for co-occurring posttraumatic stress disorder (PTSD) and substance use disorders is well established, yet direct evidence for comparative effectiveness across treatments is lacking. The present study compared the ...

https://doi.org/10.1176/appi.ajp.22010071