American Journal of Psychiatry

One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the ...

https://doi.org/10.1176/appi.ajp.20230025

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Polygenic Risk and Episode Polarity Among Individuals With Bipolar Disorder

Publication date: 18 January 2023

Pages200–208

Objective: The authors investigated associations between polygenic liabilities for bipolar disorder, major depression, and schizophrenia and episode polarity among individuals with bipolar disorder. Methods: The sample consisted of 2,705 individuals ...

https://doi.org/10.1176/appi.ajp.22010003

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Moderate Alcohol Consumption and Depression: A Marginal Structural Model Approach Promoting Causal Inference

Publication date: 18 January 2023

Pages209–217

Objective: Moderate alcohol consumption is associated with decreased risk for depression, but it remains unclear whether this is a causal relationship or a methodological artifact. To compare the effects of consistent abstinence and occasional, moderate, ...

https://doi.org/10.1176/appi.ajp.22010043

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Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy

Publication date: 18 January 2023

Pages218–229

Objective: The authors sought to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with ...

https://doi.org/10.1176/appi.ajp.21070727

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Functional Connectivity Mapping for rTMS Target Selection in Depression

Publication date: 01 March 2023

Pages230–240

Objective: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize treatment targets. However, the efficacy of this approach is unclear, with ...

https://doi.org/10.1176/appi.ajp.20220306

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Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study

Publication date: 15 February 2023

Pages241–251

Objective: The purpose of this study was to investigate the efficacy of cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive therapy for patients with major depressive disorder and nonresponse to at least ...

https://doi.org/10.1176/appi.ajp.20220504