American Journal of Psychiatry
- Volume 180
- Number 4
- April 2023
Editor’s Note
Editorials
Review and Overview
Publication date: 01 April 2023
Pages265–276While autism spectrum disorder affects nearly 2% of children in the United States, little is known with certainty concerning the etiologies and brain systems involved. This is due, in part, to the substantial heterogeneity in the presentation of the core ...
https://doi.org/10.1176/appi.ajp.20230153Articles
Publication date: 07 September 2022
Pages277–284Objective: Mitochondrial dysfunction has been implicated in the pathophysiology of autism spectrum disorder (ASD) in previous studies of postmortem brain or peripheral samples. The authors investigated whether and where mitochondrial dysfunction occurs in ...
https://doi.org/10.1176/appi.ajp.22010014Publication date: 22 February 2023
Pages285–293Objective: Family history is an established risk factor for mental illness. The authors sought to investigate whether polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. Methods: ...
https://doi.org/10.1176/appi.ajp.20220476Publication date: 01 April 2023
Pages294–304Objective: Emerging evidence supports a bidirectional phenotypic association between stress-related disorders and autoimmune disease. However, the biological underpinnings remain unclear. Here, the authors examined whether and how shared genetics ...
https://doi.org/10.1176/appi.ajp.20220364Publication date: 21 September 2022
Pages305–317Objective: Deficits in social cognition consistently underlie functional disabilities in a wide range of psychiatric disorders. Neuroimaging studies have suggested that the anterior insula is a “common core” brain region that is impaired across ...
https://doi.org/10.1176/appi.ajp.21010053