American Journal of Psychiatry
- Volume 176
- Number 5
- May 2019
Editor's Note
Editorials
Commentary
Perspectives in Global Mental Health
Images in Psychiatry
Reviews and Overviews
Publication date: 01 May 2019
Pages342–347Over the past two decades, research in the biology and treatment of major depression has led to advances in our understanding of the biology of the disorder and to the development of novel treatments. While progress has been made, a number of key issues ...
https://doi.org/10.1176/appi.ajp.2019.19030273Articles
Publication date: 05 April 2019
Pages348–357Objective:Almost two-thirds of patients with major depressive disorder do not achieve remission with initial treatments. Thus, identifying and providing effective, feasible, and safe “next-step” treatments are clinical imperatives. This study explores ...
https://doi.org/10.1176/appi.ajp.2018.18091079Publication date: 29 March 2019
Pages358–366Objective:The authors evaluated improvement in irritability with antidepressant treatment and its prognostic utility in treatment-seeking adult outpatients with major depressive disorder.Methods:Mixed-model analyses were used to assess changes in ...
https://doi.org/10.1176/appi.ajp.2018.18030355Publication date: 15 February 2019
Pages367–375Objective:Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for refractory major depressive disorder, yet no studies have characterized trajectories of rTMS response. The aim of this study was to characterize response ...
https://doi.org/10.1176/appi.ajp.2018.18091096Publication date: 08 March 2019
Pages376–387Objective:Interest in candidate gene and candidate gene-by-environment interaction hypotheses regarding major depressive disorder remains strong despite controversy surrounding the validity of previous findings. In response to this controversy, the ...
https://doi.org/10.1176/appi.ajp.2018.18070881Publication date: 04 January 2019
Pages388–400Objective:The N-methyl-d-aspartate receptor antagonist ketamine produces rapid and sustained antidepressant actions even in patients with treatment-resistant depression. Vascular endothelial growth factor (VEGF) has been implicated in the effects of ...
https://doi.org/10.1176/appi.ajp.2018.17121368Publication date: 29 March 2019
Pages401–409Objective:Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration. The purpose of this study was to evaluate the ...
https://doi.org/10.1176/appi.ajp.2018.18070834Letters to the Editor
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