American Journal of Psychiatry

The objective of this article is to provide an operational definition of recovery from alcohol use disorder (AUD) to facilitate the consistency of research on recovery and stimulate further research. The construct of recovery has been difficult to ...

https://doi.org/10.1176/appi.ajp.21090963

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Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

Publication date: 07 September 2022

Pages814–823

Objective:Individuals with posttraumatic stress disorder (PTSD) are significantly more likely to be diagnosed with cardiovascular disease (CVD) (e.g., myocardial infarction, stroke). The evidence for this link is so compelling that the National Institutes ...

https://doi.org/10.1176/appi.ajp.21111113

Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression: A Nationwide Swedish Study of Siblings

Publication date: 21 September 2022

Pages824–832

Objective:Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial ...

https://doi.org/10.1176/appi.ajp.21090954

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Publication date: 07 September 2022

Pages833–843

Objective:Mental disorders are heritable and polygenic, and genome-wide genetic correlations (r_g) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, r_g ...

https://doi.org/10.1176/appi.ajp.21101051

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Association Between Polygenic Risk Scores and Outcome of ECT

Publication date: 07 September 2022

Pages844–852

Objective:Identifying biomarkers associated with response to electroconvulsive therapy (ECT) may aid clinical decisions. The authors examined whether greater polygenic liabilities for major depressive disorder, bipolar disorder, and schizophrenia are ...

https://doi.org/10.1176/appi.ajp.22010045

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Similar Rates of Deleterious Copy Number Variants in Early-Onset Psychosis and Autism Spectrum Disorder

Publication date: 24 August 2022

Pages853–861

Objective:Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 years of age, is thought to be more strongly influenced by genetic factors than ...

https://doi.org/10.1176/appi.ajp.21111175