American Journal of Psychiatry

The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened ...

https://doi.org/10.1176/appi.ajp.19010091

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The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

Publication date: 01 August 2023

Pages548–564

A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes ...

https://doi.org/10.1176/appi.ajp.19010020

Overview of Alcohol Use Disorder

Henry R. Kranzler, M.D.

Publication date: 01 August 2023

Pages565–572

Alcohol is regularly consumed throughout most of the world, including by nearly half the U.S. population age 12 or older. Heavy drinking, which is also common, contributes to multiple adverse medical, psychiatric, and social outcomes and more than 140,000 ...

https://doi.org/10.1176/appi.ajp.20230488

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A Comprehensive Multilevel Analysis of the Bucharest Early Intervention Project: Causal Effects on Recovery From Early Severe Deprivation

Publication date: 22 May 2023

Pages573–583

Objective: The Bucharest Early Intervention Project is the first randomized controlled trial of foster care as an alternative to institutional care. The authors synthesized data from nearly 20 years of assessments of the trial to determine the overall ...

https://doi.org/10.1176/appi.ajp.20220672

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Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample

Publication date: 07 June 2023

Pages584–593

Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes have uncovered key differences in the underlying genetic architectures of alcohol consumption and alcohol use disorder (AUD), with the two traits having opposite ...

https://doi.org/10.1176/appi.ajp.21090892