Investigators from minoritized backgrounds are underrepresented in psychiatric research. That underrepresentation contributes to disparities in outcomes of access to mental health care. Drawing on lived experience, scholarly qualitative reports, and ...

https://doi.org/10.1176/appi.ajp.20220685

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Disparities in Suicide-Related Behaviors Across Sexual Orientations by Gender: A Retrospective Cohort Study Using Linked Health Administrative Data

Publication date: 07 June 2023

Pages660–667

Objective: The authors used a population-representative sample and health administrative data to quantify suicide-related behavior leading to acute care or deaths across self-identified heterosexual, gay/lesbian, and bisexual individuals. Methods: Data from ...

https://doi.org/10.1176/appi.ajp.20220763

Zuranolone for the Treatment of Postpartum Depression

Publication date: 26 July 2023

Pages668–675

Objective: Postpartum depression (PPD) is a common perinatal complication with adverse maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone, a positive allosteric modulator of synaptic and extrasynaptic GABAA ...

https://doi.org/10.1176/appi.ajp.20220785

Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo‐Controlled Phase 3 Trial

Publication date: 03 May 2023

Pages676–684

Objective: This study assessed the efficacy and safety of a 14-day treatment course of once-daily zuranolone 50 mg, an investigational oral positive allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, for the treatment of major ...

https://doi.org/10.1176/appi.ajp.20220459

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Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants

Publication date: 12 July 2023

Pages685–698

Objective: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for ...

https://doi.org/10.1176/appi.ajp.20220304