Objective: Major depressive disorder (MDD) is highly heterogeneous. Standard typology partly captures the disorder’s symptomatic heterogeneity, although whether it adequately captures etiological heterogeneity remains elusive. The aim of this study was to ...

https://doi.org/10.1176/appi.ajp.20220906

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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

Publication date: 01 October 2023

Pages723–738

Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present ...

https://doi.org/10.1176/appi.ajp.21121266

Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response

Publication date: 26 July 2023

Pages739–754

Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on bulk-tissue ...

https://doi.org/10.1176/appi.ajp.20220478

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Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts

Publication date: 16 August 2023

Pages755–765

Objective: Previous population-based studies have identified associations between childhood neurodevelopmental traits and depression in childhood, adolescence, and young adulthood. However, neurodevelopmental traits are highly correlated with each other, ...

https://doi.org/10.1176/appi.ajp.20220868

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Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring

Publication date: 06 September 2023

Pages766–777

Objective: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in ...

https://doi.org/10.1176/appi.ajp.21111176