American Journal of Psychiatry

Irritability, defined as proneness to anger that may impair an individual’s functioning, is common in youths. There has been a recent upsurge in relevant research. The authors combine systematic and narrative review approaches to integrate the latest ...

https://doi.org/10.1176/appi.ajp.20230256

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Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability

Publication date: 29 February 2024

Pages291–298

Objective:The authors investigated the neural impact of intranasal oxytocin on emotion processing areas in youths with severe irritability in the context of disruptive mood and behavior disorders.Methods:Fifty-two participants with severe irritability, as ...

https://doi.org/10.1176/appi.ajp.20230174

Sex-Specific Distributed White Matter Microarchitectural Alterations in Preadolescent Youths With Anxiety Disorders: A Mega-Analytic Study

Publication date: 13 March 2024

Pages299–309

Objective:Anxiety disorders are among the most common psychiatric disorders in youths and emerge during childhood. This is also a period of rapid white matter (WM) development, which is critical for efficient neuronal communication. Previous work in ...

https://doi.org/10.1176/appi.ajp.20221048

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Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood

Publication date: 13 March 2024

Pages310–321

Objective:The role of negative parenting in the development of callous-unemotional (CU) traits remains unclear. Both negative parenting and CU traits are influenced by genetic and environmental factors. The authors used genetically informed longitudinal ...

https://doi.org/10.1176/appi.ajp.20230208

Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder

Publication date: 29 February 2024

Pages322–329

Objective:The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample.Methods:To this end, 1,244,516 offspring in intact families with ...

https://doi.org/10.1176/appi.ajp.20230376

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N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm

Publication date: 29 February 2024

Pages330–341

Objective:Schizophrenia often occurs during youth, and psychosis risk syndrome occurs before the onset of psychosis. The aim of this study was to determine whether the visual event-related potential responses in youths with psychosis risk syndrome were ...

https://doi.org/10.1176/appi.ajp.20221013