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American Journal of Psychiatry

  • Volume 170
  • Number 4
  • April 2013

In This Issue

Perspectives

Editorials

Perspectives

Clinical Case Conference

Publication date: 01 April 2013

Pages366–369

Late-onset agranulocytosis is rare during treatment with clozapine, especially in monotherapy. The authors describe a case of agranulocytosis that emerged after 19 years of continuous clozapine monotherapy. The discovery of the agranulocytosis was due to ...

https://doi.org/10.1176/appi.ajp.2012.12081036

Perspectives

Images in Psychiatry

Perspectives

Reviews and Overviews

Publication date: 01 April 2013

Pages372–382

The hypothesis that rapid eye movement (REM) sleep disturbances are the hallmark of posttraumatic stress disorder (PTSD), proposed by Ross and colleagues in 1989, has stimulated a wealth of clinical, preclinical, and animal studies on the role of sleep in ...

https://doi.org/10.1176/appi.ajp.2012.12040432

New Research

Articles

Publication date: 01 April 2013

Pages383–390

Alcohol and drug use are known to increase the risk for traumatic brain injury (TBI), but the reverse was also true in this study of active-duty U.S. Air Force enlisted and officer personnel. A greater risk for alcohol and nicotine dependence and drug ...

https://doi.org/10.1176/appi.ajp.2012.12010126

Publication date: 01 April 2013

Pages391–398

ObjectiveUnderstanding the relationship between fetal growth and autism spectrum disorder (ASD) is likely to advance the search for genetic and nongenetic causes of ASD. The authors explored the associations between fetal growth, gestational age, and ASD ...

https://doi.org/10.1176/appi.ajp.2012.12040543

Publication date: 01 April 2013

Pages399–407

Immunization with a nicotine conjugate vaccine (3′-AmNic-rEPA) significantly reduced nicotine’s ability to enter the brain and bind to β2-containing nicotinic acetylcholine receptors (β2*-nAChRs) by sequestering nicotine in the blood. Healthy tobacco ...

https://doi.org/10.1176/appi.ajp.2012.12060793

Publication date: 01 April 2013

Pages408–413

ObjectiveEarly onset of regular smoking is associated with an elevated risk for later nicotine dependence. Whether or not this association is causal is unknown and has substantial public policy implications.MethodThe authors used a monozygotic co-twin ...

https://doi.org/10.1176/appi.ajp.2012.12030321

Publication date: 01 April 2013

Pages426–433

ObjectiveThe relationship between depression and estrogen withdrawal remains controversial. The authors examined the effects of gonadotropin-releasing hormone agonist-induced ovarian suppression on mood, sleep, sexual function, and nighttime hot flushes. ...

https://doi.org/10.1176/appi.ajp.2012.12010117

Publication date: 01 April 2013

Pages434–441

ObjectiveUnderstanding the origins of negative cognitive style could provide a means to prevent adult depression. Cognitive style is an important target for intervention because although it is not possible to remove the stress and adversities in people’s ...

https://doi.org/10.1176/appi.ajp.2012.12050673

Communications and Updates

Letters to the Editor

Communications and Updates

Books Received

Past Issues

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