American Journal of Psychiatry
- Volume 157
- Number 2
- February 2000
Editorial
Images In Neuroscience
Special Article
Publication date: 01 February 2000
Pages163–171OBJECTIVE: Cross-sectional studies are often used in psychiatric research as a basis of longitudinal inferences about developmental or disease processes. While the limitations of such usage are often acknowledged, these are often understated. The authors ...
https://doi.org/10.1176/appi.ajp.157.2.163Publication date: 01 February 2000
Pages172–178OBJECTIVE: Although schizophrenia is generally regarded as an illness with onset in late adolescence or early adult life, a sizeable minority of patients first become ill in middle or old age. Inconsistencies in diagnostic systems and nomenclature, ...
https://doi.org/10.1176/appi.ajp.157.2.172Regular Article
Publication date: 01 February 2000
Pages179–184OBJECTIVE: Pregnancy poses major challenges for the treatment of bipolar disorder, and information to guide clinical care remains very sparse. The authors sought to determine the illness recurrence risk for women with bipolar disorder who discontinue ...
https://doi.org/10.1176/appi.ajp.157.2.179Publication date: 01 February 2000
Pages185–189OBJECTIVE: The purpose of this study was to determine the extent of infant medication exposure through breast-feeding during maternal treatment with paroxetine. METHOD: Breast milk and paired maternal and infant sera were collected after 10 days of ...
https://doi.org/10.1176/appi.ajp.157.2.185Publication date: 01 February 2000
Pages190–195OBJECTIVE: In a previous study, the authors demonstrated an association between prenatal famine in middle to late gestation and major affective disorders requiring hospitalization. In this study, they sought to examine the association by using newly ...
https://doi.org/10.1176/appi.ajp.157.2.190Publication date: 01 February 2000
Pages196–202OBJECTIVE: Epidemiologic evidence linking obstetric complications to schizophrenia has been positive but inconclusive. One reason for the lack of conclusive evidence may be the inconsistency in measuring disturbances of fetal/neonatal brain development ...
https://doi.org/10.1176/appi.ajp.157.2.196Publication date: 01 February 2000
Pages203–212OBJECTIVE: The aim of the study was to determine whether a history of obstetric complications and congenital minor physical anomalies are related to differences in the characteristics of brain structures observed within monozygotic twin pairs discordant ...
https://doi.org/10.1176/appi.ajp.157.2.203Publication date: 01 February 2000
Pages213–219OBJECTIVE: This study examined clinical differences between subjects with early-onset and adult-onset psychotic mania. METHOD: Subjects were from an epidemiologically derived, hospitalized sample who met criteria for definite bipolar disorder after 24 ...
https://doi.org/10.1176/appi.ajp.157.2.213Publication date: 01 February 2000
Pages220–228OBJECTIVE: Psychotic affective disorders are the most prevalent idiopathic psychoses, but their outcome from onset has rarely been studied. In this study, the authors determined the rate and latency of syndromal recovery and rates of functional recovery ...
https://doi.org/10.1176/appi.ajp.157.2.220Publication date: 01 February 2000
Pages229–233OBJECTIVE: The authors of this study examined multiple recurrences of unipolar major depressive disorder. METHOD: A total of 318 subjects with unipolar major depressive disorder were prospectively followed for 10 years within a multicenter naturalistic ...
https://doi.org/10.1176/appi.ajp.157.2.229Publication date: 01 February 2000
Pages234–238OBJECTIVE: The prevalence of seasonal affective disorder—as measured by the Seasonal Pattern Assessment Questionnaire—has been found to be unexpectedly low among Icelanders. The aim of this cross-sectional study was to measure seasonal variations in the ...
https://doi.org/10.1176/appi.ajp.157.2.234Publication date: 01 February 2000
Pages239–243OBJECTIVE: Few controlled trials of pharmacologic intervention in women with antidepressant-associated sexual dysfunction have been reported, and there is uncertainty about the usefulness of putative treatments and the assessment methodologies. The ...
https://doi.org/10.1176/appi.ajp.157.2.239Publication date: 01 February 2000
Pages244–247OBJECTIVE: The psychiatric and medical characteristics of victims of homicide have not been systematically studied and are often confounded by race. This study was undertaken to determine health and social factors contributing to the risk of being ...
https://doi.org/10.1176/appi.ajp.157.2.244Publication date: 01 February 2000
Pages248–254OBJECTIVE: Little is known about the impact of comorbid psychiatric symptoms in persons with HIV. This study estimates the burden on health-related quality of life associated with comorbid psychiatric conditions in a nationally representative sample of ...
https://doi.org/10.1176/appi.ajp.157.2.248Publication date: 01 February 2000
Pages255–261OBJECTIVE: Previous studies have shown elevated autonomic responses to startling tones in trauma survivors with chronic posttraumatic stress disorder (PTSD). The origin of these abnormal responses is obscure. The present study attempted to clarify this ...
https://doi.org/10.1176/appi.ajp.157.2.255Clinical Case Conference
Images In Psychiatry
Brief Report
Publication date: 01 February 2000
Pages269–271OBJECTIVE: Recent in vivo imaging studies indicate a dysregulated presynaptic function of the striatal dopaminergic system in patients with schizophrenia. To further explore the basis of this phenomenon, the authors studied brain dopamine transporter ...
https://doi.org/10.1176/appi.ajp.157.2.269Publication date: 01 February 2000
Pages272–274OBJECTIVE: This study explored the genetic basis of neurological soft signs in schizophrenia and addressed disturbed hemispheric lateralization. METHOD: The authors investigated neurological soft signs in 30 monozygotic twin pairs, 13 pairs discordant for ...
https://doi.org/10.1176/appi.ajp.157.2.272Publication date: 01 February 2000
Pages275–277OBJECTIVE: The evidence for verbal working memory deficits in schizophrenia has been inconsistent. Few studies have evaluated verbal working memory in the first-degree relatives of schizophrenia patients, who likely share the genetic diathesis for ...
https://doi.org/10.1176/appi.ajp.157.2.275Publication date: 01 February 2000
Pages278–280OBJECTIVE: The authors used a functional neuroimaging study with a working memory probe to investigate the pathophysiology of attention deficit hyperactivity disorder (ADHD). Their goal was to compare regional cerebral blood flow (rCBF) changes related to ...
https://doi.org/10.1176/appi.ajp.157.2.278Publication date: 01 February 2000
Pages281–283OBJECTIVE: The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection. METHOD: Using computer-assisted morphometric ...
https://doi.org/10.1176/appi.ajp.157.2.281Publication date: 01 February 2000
Pages284–286OBJECTIVE: The purpose of this study was to assess cAMP-dependent protein kinase A in patients with obsessive-compulsive disorder (OCD). METHOD: The levels and the activity of protein kinase A were evaluated in whole platelets obtained from 12 unmedicated ...
https://doi.org/10.1176/appi.ajp.157.2.284Publication date: 01 February 2000
Pages287–289OBJECTIVE: The authors examined the efficacy, tolerability, and safety of ondansetron, a selective serotonin 3 receptor antagonist, in patients with tardive dyskinesia. METHOD: Twenty patients with schizophrenia who had neuroleptic-induced tardive ...
https://doi.org/10.1176/appi.ajp.157.2.287Publication date: 01 February 2000
Pages290–292OBJECTIVE: Low striatal dopamine D2 receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors ...
https://doi.org/10.1176/appi.ajp.157.2.290Book Forum: CHILD PSYCHIATRY
Book Forum: GERIATRIC PSYCHIATRY
Book Forum: HISTORICAL TRENDS AND THE STRUCTURE OF BELIEF
Book Forum: PSYCHOANALYSIS
Letter to the Editor
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