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American Journal of Psychiatry

  • Volume 178
  • Number 12
  • December 2021

Editor's Note

Editorials

Reviews and Overviews

Publication date: 01 December 2021

Pages1082–1088

For many decades, psychiatric treatment has been primarily guided by two major paradigms of psychopathology: a neurochemical paradigm leading to the development of medications and a psychological paradigm resulting in the development of psychotherapies. A ...

https://doi.org/10.1176/appi.ajp.2021.21101034

Articles

Publication date: 10 September 2021

Pages1089–1097

Objective: This observational study examined the effects of electroconvulsive therapy (ECT) on suicide and all-cause mortality risk in older psychiatric patients. Methods: Participants were Medicare-insured psychiatric inpatients age 65 or older. ...

https://doi.org/10.1176/appi.ajp.2021.21040351

Publication date: 23 September 2021

Pages1098–1106

Objective: In a phase 3 randomized double-blind placebo-controlled study, the authors investigated the efficacy and safety of 42 mg/day of lumateperone in patients with bipolar I or bipolar II disorder experiencing a major depressive episode. Methods: ...

https://doi.org/10.1176/appi.ajp.2021.20091339

Publication date: 14 October 2021

Pages1107–1118

Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between ...

https://doi.org/10.1176/appi.ajp.2021.20121776

Publication date: 14 October 2021

Pages1119–1128

Objective: Structural neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological limitations, lack of distinction between MDD and late-life depression (LLD), or ...

https://doi.org/10.1176/appi.ajp.2021.21010088

Letters to the Editor

Appreciation

Past Issues

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No.11
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1 Nov 2024

Vol. 181 | No. 11

No.10
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1 Oct 2024

Vol. 181 | No. 10

No.9
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1 Sep 2024

Vol. 181 | No. 9

No.8
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1 Aug 2024

Vol. 181 | No. 8