American Journal of Psychiatry

For many decades, psychiatric treatment has been primarily guided by two major paradigms of psychopathology: a neurochemical paradigm leading to the development of medications and a psychological paradigm resulting in the development of psychotherapies. A ...

https://doi.org/10.1176/appi.ajp.2021.21101034

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Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients

Publication date: 10 September 2021

Pages1089–1097

Objective: This observational study examined the effects of electroconvulsive therapy (ECT) on suicide and all-cause mortality risk in older psychiatric patients. Methods: Participants were Medicare-insured psychiatric inpatients age 65 or older. ...

https://doi.org/10.1176/appi.ajp.2021.21040351

Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial

Publication date: 23 September 2021

Pages1098–1106

Objective: In a phase 3 randomized double-blind placebo-controlled study, the authors investigated the efficacy and safety of 42 mg/day of lumateperone in patients with bipolar I or bipolar II disorder experiencing a major depressive episode. Methods: ...

https://doi.org/10.1176/appi.ajp.2021.20091339

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Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies

Publication date: 14 October 2021

Pages1107–1118

Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between ...

https://doi.org/10.1176/appi.ajp.2021.20121776

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Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis

Publication date: 14 October 2021

Pages1119–1128

Objective: Structural neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological limitations, lack of distinction between MDD and late-life depression (LLD), or ...

https://doi.org/10.1176/appi.ajp.2021.21010088