American Journal of Psychiatry
- Volume 178
- Number 12
- December 2021
Editor's Note
Editorials
Reviews and Overviews
Publication date: 01 December 2021
Pages1082–1088For many decades, psychiatric treatment has been primarily guided by two major paradigms of psychopathology: a neurochemical paradigm leading to the development of medications and a psychological paradigm resulting in the development of psychotherapies. A ...
https://doi.org/10.1176/appi.ajp.2021.21101034Articles
Publication date: 10 September 2021
Pages1089–1097Objective: This observational study examined the effects of electroconvulsive therapy (ECT) on suicide and all-cause mortality risk in older psychiatric patients. Methods: Participants were Medicare-insured psychiatric inpatients age 65 or older. ...
https://doi.org/10.1176/appi.ajp.2021.21040351Publication date: 23 September 2021
Pages1098–1106Objective: In a phase 3 randomized double-blind placebo-controlled study, the authors investigated the efficacy and safety of 42 mg/day of lumateperone in patients with bipolar I or bipolar II disorder experiencing a major depressive episode. Methods: ...
https://doi.org/10.1176/appi.ajp.2021.20091339Publication date: 14 October 2021
Pages1107–1118Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between ...
https://doi.org/10.1176/appi.ajp.2021.20121776Publication date: 14 October 2021
Pages1119–1128Objective: Structural neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological limitations, lack of distinction between MDD and late-life depression (LLD), or ...
https://doi.org/10.1176/appi.ajp.2021.21010088