Adversity early in life is common and is a major risk factor for the onset of psychopathology. Delineating the neurodevelopmental pathways by which early adversity affects mental health is critical for early risk identification and targeted treatment ...

https://doi.org/10.1176/appi.ajp.2021.21090944

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Amyloid and Tau in Alzheimer’s Disease: Biomarkers or Molecular Targets for Therapy? Are We Shooting the Messenger?

Publication date: 01 November 2021

Pages1014–1025

Alzheimer’s disease is a neuropsychiatric disorder with devastating clinical and socioeconomic consequences. Since the original description of the neuropathological correlates of the disorder, neuritic plaques and neurofibrillary tangles have been ...

https://doi.org/10.1176/appi.ajp.2021.19080873

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Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology

Publication date: 19 August 2021

Pages1026–1036

Objective: Childhood abuse represents one of the most potent risk factors for developing psychopathology, especially in females. Evidence suggests that exposure to early-life adversity may be related to advanced maturation of emotion processing neural ...

https://doi.org/10.1176/appi.ajp.2021.20081192

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Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

Publication date: 14 October 2021

Pages1037–1049

Objective: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of ...

https://doi.org/10.1176/appi.ajp.2021.20101526

Predictors of Suicide Attempt Within 30 Days After First Medically Documented Suicidal Ideation in U.S. Army Soldiers

Publication date: 01 September 2021

Pages1050–1059

Objective: The authors sought to identify predictors of imminent suicide attempt (within 30 days) among U.S. Army soldiers following their first documented suicidal ideation. Methods: Using administrative data from the Army Study to Assess Risk and ...

https://doi.org/10.1176/appi.ajp.2021.20111570

On the Genetic and Environmental Relationship Between Suicide Attempt and Death by Suicide

Publication date: 14 July 2021

Pages1060–1069

Objective: The authors examined the extent to which the genetic and environmental etiology of suicide attempt and suicide death is shared or unique. Methods: The authors used Swedish national registry data for a large cohort of twins, full siblings, ...

https://doi.org/10.1176/appi.ajp.2020.20121705