AJP Audio
Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research. Discover more podcasts produced by the American Psychiatric Association.
Latest Episode
July 2024: Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder
Dr. Lina Jonsson (Sahlgrenska Academy at University of Gothenburg, Sweden) joins AJP Audio to discuss the association of occupational dysfunction and hospital admissions with polygenic profiles in patients with bipolar disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of AJP.
All Episodes
July 2024: Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder
Dr. Lina Jonsson (Sahlgrenska Academy at University of Gothenburg, Sweden) joins AJP Audio to discuss the association of occupational dysfunction and hospital admissions with polygenic profiles in patients with bipolar disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of AJP.
TranscriptJune 2024: Long-Term Course of Remission and Recovery in Psychotic Disorders
Ms. Sara Tramazzo (Stony Brook University) joins AJP Audio to discuss the long-term outlook for patients with schizophrenia spectrum disorders and other psychotic disorders over the course of 25 years. Afterwards, Dr. Ned Kalin joins to discuss the rest of the June issue of AJP..
TranscriptMay 2024: Predictors of Substance Use Initiation by Early Adolescence
Dr. ReJoyce Green (Medical University of South Carolina, Charleston, SC) joins AJP Audio to discuss predictors of substance use initiation in a large cohort of early adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin speaks with AJP Deputy Editor Dr. Kathleen Brady about the May issue of AJP, a special issue guest edited by Dr. Brady focusing on latest developments in the understanding and treatment of substance use disorders.
TranscriptApril 2024: Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial
Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin youths with severe irritability.
TranscriptMarch 2024: Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial
Dr. Drew Rothenberg (Duke University, Durham, NC) joins AJP Audio to discuss the long term, intergenerational impacts of the Fast Track program, and whether the mental health intervention lead to lasting improvements in mental health, including in the participants own children.
TranscriptFebruary 2024: Trends in Prevalence of Cannabis Use Disorder Among U.S. Veterans With and Without Psychiatric Disorders Between 2005 and 2019
Dr. Ofir Livne (Columbia University, New York) joins AJP Audio to discuss recent trends in the prevalence of cannabis use disorder youths in US veterans with and without psychiatric disorder diagnosis. Dr. Ned Kalin joins afterwards to discuss how the rest of the February issue of AJP touches on cannabis use disorder and other substance use disorders.
TranscriptJanuary 2024: Predicting Acute Changes in Suicidal Ideation and Planning: A Longitudinal Study of Symptom Mediators and the Role of the Menstrual Cycle in Female Psychiatric Outpatients With Suicidality
Dr. Jaclyn Ross, Ms. Jordan Barone, and Dr. Tory Eisenlohr-Moul (University of Illinois at Chicago) join AJP Audio to discuss the impact of the menstrual cycle on suicide ideation and planning in psychiatric patients with suicidality. Afterwards, American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin brings us up to date on the rest of the January issue of AJP.
TranscriptDecember 2023: Racial and Ethnic Disparities in COVID-19-Related Stressor Exposure and Adverse Mental Health Outcomes Among Health Care Workers
Dr. Aaron Samuel Breslow (Montefiore Medical Center and Albert Einstein College of Medicine) joins AJP Audio to discuss the racial and ethnic disparities in the impact of COVID-19 and pandemic related stressors and adverse mental health outcomes on health care workers in the Bronx, New York. Following we’ll once again check in with American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin on the rest of the December issue of AJP.
TranscriptNovember 2023: Inequalities in the Incidence of Psychotic Disorders Among Racial and Ethnic Groups
Dr. Winston Chung (Kaiser Permanente Northern California) joins AJP Audio to discuss inequalities in the diagnosis of psychotic disorders between racial and ethnic groups in a large cohort. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the November issue of AJP, which focuses on different aspects of psychotic disorder.
TranscriptOctober 2023: Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts
Dr. Luis Farhat and Dr. Guilherme V. Polanczyk (University of São Paulo, Brazil) join AJP Audio to discuss the impact of socioenviromental factors, emotional dysregulation, and other factors impact neurodevelopment in children. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together.
TranscriptSeptember 2023: Disparities in Suicide-Related Behaviors Across Sexual Orientations by Gender: A Retrospective Cohort Study Using Linked Health Administrative Data
Dr. Antony Chum (York University, Toronto) joins AJP Audio to discuss disparities in suicide-related behaviors between sexual orientations by gender in a large cohort from the province of Ontario. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together.
TranscriptAugust 2023: A Comprehensive Multilevel Analysis of the Bucharest Early Intervention Project: Causal Effects on Recovery From Early Severe Deprivation
Dr. Lucy S. King (Tulane University School of Medicine, New Orleans) and Dr. Kathryn L. Humphreys (Vanderbilt University, Nashville) join AJP Audio to discuss the long term impacts of a pioneering randomized controlled trial that looked at that looked at the impacts of institutional care versus home foster care in children, the Bucharest Early Intervention Project. They also discuss the impacts of deprivation on children’s development and mental health, and the thorny ethics of research involving children.
TranscriptJuly 2023: Differences in Social Determinants of Health Underlie Racial/Ethnic Disparities in Psychological Health and Well-Being: Study of 11,143 Older Adults
Dr. Dylan J. Jester (VA Palo Alto Medical Center in Palo Alto, California) joins AJP Audio to discuss the differential impact of selected social determinants of health on the mental health outcomes of older Black, White, and Latinx adults in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the July issue.
TranscriptJune 2023: Opioid Prescribing and Suicide Risk in the United States
Dr. Mark Olfson (Columbia University) discusses the links between opioid prescribing and suicide risk in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the June issue.
TranscriptMay 2023: Attention Bias Modification Treatment Versus a Selective Serotonin Reuptake Inhibitor Or Waiting List Control for Social Anxiety Disorder
Ms. Gal Arad (Tel Aviv University, Tel Aviv, Israel) discusses a non-pharmacological intervention for the treatment of social anxiety disorder in comparison with standard care. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the May issue.
TranscriptApril 2023: Translational Neuroscience Approaches to Understanding Autism
Dr. David G. Amaral (University of California, Davis) is an author on a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder. He joins us on AJP Audio to discuss it. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue.
TranscriptMarch 2023: Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder
Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue.
TranscriptFebruary 2023: Adversity, Toxic Stress, and Racial Disparities in Children, and Evaluating the Evidence for Brain-Based Biotypes
This episode of AJP Audio features two articles from the February issue of AJP. First up, we have Nathaniel G. Harnett, Ph.D. (Harvard Medical School), discussing the impact of adversity and stress on racial disparities in childhood brain development among Black and White American children. Following that, Ziv Ben-Zion, Ph.D. (Yale University), discusses a non-exact replication study of a study published in AJP by Stevens et al. (previously featured on AJP Audio) looking at brain-based biotypes to guide treatment following trauma. And of course, we’ll check in with AJP Editor-in-Chief Dr. Ned Kalin about the rest of the February issue and how it all fits together.
TranscriptJanuary 2023: Resting-State Connectivity and Response to Psychotherapy Treatment in Adolescents and Adults With OCD: A Randomized Clinical Trial
Dr. Stefanie Russman Block (University of Michigan, Ann Arbor) discusses a trial looking at whether connectivity patterns in the brain can be used to predict treatment response in patients with obsessive-compulsive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses childhood and neurodeveloment-related psychiatric disorders explored in the January issue.
TranscriptDecember 2022: A Novel, Brief, Fully Automated Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion: A Randomized Clinical Trial
Dr. Rebecca Price (University of Pittsburgh) discusses a novel, computer-based intervention designed to extend the antidepressant effects of a single dose of ketamine. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue and what draws it together.
TranscriptNovember 2022: Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy
Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together.
TranscriptOctober 2022: Neural Signatures of Pain Modulation in Short-Term and Long-Term Mindfulness Training: A Randomized Active-Control Trial
Dr. Richard Davidson (University of Wisconsin-Madison) discusses the effects of mindfulness training on the neural mechanisms of pain and what it means for the future of pain management. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses what draws together that paper and the rest of the October issue.
TranscriptSeptember 2022: Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure
Dr. Lauren A. M. Lebois (Dissociative Disorders and Trauma Research Program, McLean Hospital, Harvard Medical School) discusses persistent dissociation following trauma exposure and whether it can be predictive of later psychiatric outcomes in at risk populations. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue and what draws it together.
TranscriptAugust 2022: Subcortical Brain Development in Autism and Fragile X Syndrome
Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome. Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis.
TranscriptJuly 2022: Digital Intervention for Cognitive Deficits in Major Depression
Dr. Richard S.E. Keefe (Duke University Medical Center, Durham, North Carolina) discusses an article looking at an intervention for major depressive disorder that takes the form of a videogame. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the July issue’s theme.
June 2022: Structural Racism and Mental Health Disparities
AJP Editor-in-Chief Dr. Ned Kalin discusses the June issue with guest editor Dr. Crystal Barksdale (National Institute on Minority Health and Health Disparities). The issue focuses on mental health disparities, the pervasive negative consequences of structural racism, and the importance of community-wide and systemic interventions.
May 2022: The Emergence of Psychiatry: 1650–1850
Dr. Kenneth Kendler (Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, Roanoke, VA) discusses the history and emergence of psychiatry as a discipline, and how the conception of mind, body, and soul evolved. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses the May issue of AJP, and the past, present, and future of psychiatry.
April 2022: Effects of County-Level Opioid Dispensing Rates on Individual-Level Patterns of Prescription Opioid and Heroin Consumption: Evidence From National U.S. Data
Dr. Brian Kelly (Purdue University, West Lafayette, Indiana) discusses a study that found recent efforts to curb opioid prescriptions appear to have had an effect on reducing prescription opioid misuse and dependence, with no evidence that shifts in local-level opioid dispensing affected odds of heroin use, frequency of heroin use, or heroin dependence. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together.
March 2022: Genetics and Brain Transcriptomics of Completed Suicide
Dr. Giovanna Punzi and Dr. Daniel Weinberger (Lieber Institute for Brain Development, Baltimore, Maryland) discuss findings from their new paper, “Genetics and Brain Transcriptomics of Completed Suicide,” which looks at differences in the brains of those who die by violent versus less violent means of suicide. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together.
February 2022: Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD
Dr. Margaret Sibley (University of Washington, Seattle, WA) joins the podcast this month to discuss an article from the February issue of the Journal looking at patterns of remission in attention deficit hyperactivity disorder in children. Dr. Ned Kalin, Editor-in-Chief of AJP will join us afterwards to discuss the rest of the February issue of the Journal.
January 2022: Cannabis Use and the Endocannabinoid System
In this month’s AJP Audio, Dr Margert Haney (Director of the Cannabis Research Laboratory at Columbia Psychiatry) discusses her new review from the January issue of the American Journal of Psychiatry, “Cannabis Use and the Endocannabinoid System: A Clinical Perspective,” and the questions around the legal status of cannabis research. Afterward, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the January 2022 issue of AJP.
December 2021: Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients
In this month’s AJP Audio, Dr. Samuel Wilkinson (Yale University, Associate Director of the Yale Depression Research Program) discusses a study looking at the association of electro-convulsive therapy or ECT on all-cause mortality and suicide in Medicare patients with mood and bipolar disorders. Following that, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the December issue of AJP.
November 2021: Using Neuroimaging to Classify Victims of Trauma
Dr. Jennifer Stevens discusses a technique to classify trauma victims into discrete biotypes in the immediate aftermath of trauma, with the hope of providing insight into the groups that could guide treatment, and American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin puts the November, 2021 issue of AJP into context.
May 2021: Quality of Depression Care for Patients With Comorbid Substance Use Disorder
Executive Editor Michael Roy speaks with Lara N. Coughlin, Ph.D., and Lewei Allison Lin, M.D., M.S., about their article on the provision of guideline-concordant depression treatment to patients with and without substance use disorders.
April 2021: Reducing Adolescent Psychopathology in Socioeconomically Disadvantaged Children
Executive Editor Michael Roy speaks with Karen L. Bierman, Ph.D., about her article on reducing adolescent psychopathology in socioeconomically disadvantaged children with a preschool intervention..
March 2021: Psychiatry Diversity Leadership in Academic Medicine
Executive Editor Michael Roy speaks with Ayana Jordan, M.D., Ph.D., and Christina Mangurian, M.D., M.A.S., about their article on psychiatry diversity leadership in academic medicine.
February 2021: Maternal Psychological Resilience and Newborn Telomere Length
Executive Editor Michael Roy speaks with Glenn Verner, M.P.H., and Sonja Entringer, Ph.D., about their article on the relationship between maternal psychological resilience during pregnancy and newborn telomere length.
January 2021: Brain Activation and Symptom Reduction in OCD Following CBT
Executive Editor Michael Roy speaks with Luke J. Norman, Ph.D.,and Kate D. Fitzgerald, M.D., about their article examining whether brain activity is associated with treatment response to cognitive-behavioral therapy in adolescents and adults with obsessive-compulsive disorder, and whether any associations are treatment specific relative to an active control psychotherapy.
December 2020: Year in Review
Executive Editor Michael Roy speaks with American Journal of Psychiatry Editor-in-Chief Ned H. Kalin, M.D., and Deputy Editor Carolyn Rodriguez, M.D., Ph.D., about the Journal’s response to COVID-19; strategies to combat racism, social injustice, and health care inequities; research highlights from the past year; and what lies ahead in 2021.
November 2020: Brain Responses During Treatment for Alcohol Use Disorder
Executive Editor Michael Roy speaks with Sara K. Blaine, Ph.D., and Rajita Sinha, Ph.D., about their article on the use of brain imaging in the evaluation of drinking outcomes during early outpatient treatment for alcohol use disorder.
October 2020: Burnout and Depression Among Psychiatrists
Executive Editor Michael Roy speaks with Constance Guille, M.D., and Richard F. Summers, M.D., about their article on the prevalence of burnout and depressive symptoms among North American psychiatrists, demographic and practice characteristics associated with risk for these symptoms, and the correlation between burnout and depression. A related commentary on burnout by Dr. Summers also is discussed.
September 2020: Callous-Unemotional Traits and Gun Violence
Executive Editor Michael Roy speaks with Emily Robertson, M.A., and Paul Frick, Ph.D., about their article on the role that callous-unemotional traits have in the risk for gun carrying and gun use during a crime.
August 2020: Hormonal Treatments for Major Depressive Disorder
Executive Editor Michael Roy speaks with Jennifer Dwyer, M.D., Ph.D., and Awais Aftab, M.D., about the physiology of three major endocrine systems and about the evidence for hormone-based interventions in the treatment of major depressive disorder.
July 2020: Association Between the Use of Cannabis and Physical Violence in Youths
Executive Editor Michael Roy speaks with Stéphane Potvin, Ph.D., and Alexandre Dumais, M.D., Ph.D., about their meta-analysis investigating the association between cannabis use and violence, and, more specifically, the perpetration of any type of physical violence by adolescents and young adults.
June 2020: Sleep Patterns in Children With Autism Spectrum Disorder
Executive Editor Michael Roy speaks with Katherine MacDuffie, Ph.D., and Annette Estes, Ph.D., about their longitudinal neuroimaging study examining associations between sleep difficulties and developmental trajectories among infants who go on to develop autism spectrum disorder
May 2020: Psychedelics and Psychedelic-Assisted Psychotherapy
Executive Editor Michael Roy speaks with Collin Reiff, M.D., and William McDonald, M.D., about their evidence-based summary of the literature on the clinical application of psychedelic drugs in psychiatric disorders.
April 2020: Incidence of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder
Executive Editor Michael Roy speaks with Sarah A. Sullivan, Ph.D., and Stanley Zammit, Ph.D., about their research on the incidence, course, and outcome of psychotic experiences from childhood through early adulthood in the general population, and the prediction of psychotic disorder.
March 2020: Efficacy of Deep Brain Stimulation for Obsessive-Compulsive Disorder
Executive Editor Michael Roy speaks with Damiaan Denys, M.D., Ph.D., and Ilse Graat, M.D., about their research on the tolerability and effectiveness of deep brain stimulation for patients with refractory obsessive-compulsive disorder.
February 2020: Adverse Outcomes Following Buprenorphine Discontinuation
Executive Editor Michael Roy speaks with Arthur Robin Williams, M.D., M.B.E., and Mark Olfson, M.D., M.P.H., about their research on adverse health outcomes following discontinuation of buprenorphine.
January 2020: Maternal Bacterial Infection and Offspring Psychosis Risk
Executive Editor Michael Roy speaks with Younga H. Lee, Ph.D., and Stephen L. Buka, Sc.D., about their research on the association between maternal bacterial infection during pregnancy and risk for psychotic disorders in offspring.
December 2019: Dimensions of Psychopathology and Brain Structure
Executive Editor Michael Roy speaks with Antonia Kaczkurkin, Ph.D., and Theodore Satterthwaite, M.D., about their research on how different measures of brain structure (cortical thickness and volume) in youths are associated with various dimensions of psychopathology.
November 2019: CBD for the Reduction of Craving and Anxiety in Heroin Use Disorder
Executive Editor Michael Roy speaks with Yasmin Hurd, Ph.D., about her research on the potential of cannabidiol (CBD) to reduce cue-induced craving and anxiety, two critical features of addiction that often contribute to relapse and continued drug use, in drug-abstinent individuals with heroin use disorder.
October 2019: Cognitive Change in Schizophrenia and Other Psychoses
Executive Editor Michael Roy speaks with Avi Reichenberg, Ph.D., about research on cognitive decline after the first episode of schizophrenia and other psychoses.
September 2019: Sexual Harassment and Gender Discrimination in Health Care
Guest host Ann Thomas speaks with Jessica A. Gold, M.D., M.S., and Christina Mangurian, M.D., M.A.S., about their commentary on sexual harassment and gender discrimination in the health care workplace and on how mental health professionals can help remedy these inequities.
August 2019: Youth Mental Health Development
Executive Editor Michael Roy speaks with Thorhildur Halldorsdottir, Ph.D., and Elisabeth B. Binder, M.D., Ph.D., about their research on predicting depression outcomes in youths and how the interaction between FKBP5, a gene involved in regulating the stress system, and early-life exposure to intimate partner violence affects the physiological response to stress early in life, with consequences for emotional and cognitive development.
July 2019: Treating Negative Symptoms in Schizophrenia
Executive Editor Michael Roy speaks with Roscoe O. Brady, Jr., M.D., Ph.D., and Mark A. Halko, Ph.D., about their research on identifying and treating a network of connectivity in the brain corresponding to negative symptom severity in schizophrenia.
June 2019: Treating Adults With Anorexia Nervosa
Executive Editor Michael Roy speaks with Evelyn Attia, M.D., about her research evaluating the benefits of olanzapine compared with placebo for adult outpatients with anorexia nervosa.
May 2019: The Clinical Utility of Irritability in Major Depressive Disorder
Executive Editor Michael Roy speaks with Madhukar H. Trivedi, M.D., about his research evaluating the clinical utility of adding irritability to the current paradigm of measuring depressive symptom severity during the course of antidepressant treatment.
April 2019: Patient Treatment Preference for PTSD
Executive Editor Michael Roy speaks with Lori A. Zoellner, Ph.D., about her research on how patient treatment preference affects outcomes in the treatment of posttraumatic stress disorder (PTSD).
March 2019: Self-Harm and Violent Crime
Executive Editor Michael Roy speaks with Leah S. Richmond-Rakerd, Ph.D., about her research on the antecedents, clinical features, and life characteristics of adolescents who engage in both self-harming and violent criminal behaviors.
February 2019 Highlights
Executive Editor Michael Roy speaks with Patricia J. Conrod, Ph.D., about her research on the relationship between substance use and adolescent cognitive development. Deputy Editor Kathleen T. Brady, M.D., Ph.D., discusses her editorial on improving our understanding of substance use disorders.
January 2019 Highlights
Ned Kalin, M.D., begins his term as Editor-in-Chief of the Journal. Speaking with Executive Editor Michael Roy, Dr. Kalin outlines his vision for his tenure and discusses the kinds of research that will appear in the Journal.
December 2018
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Outgoing Editor-in-Chief Robert Freedman, M.D., reflects on his tenure as Editor of the Journal. Executive Editor Michael Roy reviews research on the management of vascular depression, the use of prazosin for alcohol use disorder, and how maternal severe mental illness and exposure to obstetric complications are associated with intellectual disability and psychotic disorders in children.
November 2018
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Host Ann Thomas talks with Alan S. Brown, M.D., M.P.H., about his research on the association of maternal insecticide levels with autism, and on maternal immune activation and neuropsychiatric illness. Executive Editor Michael Roy reviews research on how smoking affects cognitive functioning, a randomized controlled trial of parent-child psychotherapy, and challenges in managing mental health problems in transgender individuals.
October 2018
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Executive Editor Michael Roy talks with Betsy D. Kennard, Psy.D., about her research on an inpatient intervention and smartphone app to reduce adolescent suicide attempts following hospital discharge. Other highlights: care of patients with nonepileptic seizures; how sudden parental death affects depression in children; computerized CBT for addiction treatment; and the relationship between abortion and suicidal ideation.
September 2018
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Executive Editor Michael Roy talks with M. Camille Hoffman, M.D., about her research on the use of nutritional supplements in pregnancy. Michael Roy also speaks with Daniel S. Pine, M.D., Deputy Editor of the Journal, about a clinical trial involving ketamine and whether a framework can be established for the safe use of ketamine. Other highlights: how physical activity can affect depression, and treatment of alcohol-dependent adults who are involved with the criminal justice system.
August 2018
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Host Ann Thomas talks with Wilson M. Compton, M.D., M.P.E., about his research on patterns of misuse of prescription stimulant medication in the United States. Executive Editor Michael Roy reviews burnout among physicians, whether depression causes premature aging, discontinuation of antipsychotic treatment in schizophrenia, and risk of postpartum psychiatric episodes.
July 2018
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Executive Editor Michael Roy talks with M. Camille Hoffman, M.D., about her research on the use of nutritional supplements in pregnancy. Michael Roy also speaks with Daniel S. Pine, M.D., Deputy Editor of the Journal, about a clinical trial involving ketamine and whether a framework can be established for the safe use of ketamine. Other highlights: how physical activity can affect depression, and treatment of alcohol-dependent adults who are involved with the criminal justice system.
June 2018
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Executive Editor Michael Roy talks with Avshalom Caspi, Ph.D., about his research on the relationship between early-life stress and later changes in DNA methylation. Other highlights: a unique form of episodic psychosis, health care use before an opioid-related death, new genetic markers for depression, and the effect of antipsychotic medication on the risk for diabetes in pregnancy.
May 2018
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Executive Editor Michael Roy talks with Kelly K. Anderson, Ph.D., about her research on the effectiveness of early psychosis intervention programs. Other highlights: early-onset dementia in a patient with 22q11 deletion syndrome and Huntington’s disease, early intervention in bipolar disorder, a novel memory-based therapy with propranolol to reduce PTSD symptoms, and patterns of health care use prior to first diagnosis of a psychotic disorder.
April 2018
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Executive Editor Michael Roy speaks with Edith V. Sullivan, Ph.D., and Adolf Pfefferbaum, M.D., of Stanford University about their article investigating how drinking affects the development of the adolescent brain. Other highlights: how long the effects of ketamine can last, trends associated with substance-induced psychosis, the relationship between hormonal contraception and suicide, and treatment for patients with conversion disorder.
March 2018
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Executive Editor Michael Roy talks with Philip McGuire, F.R.C.Psych., F.Med.Sci., about his research on cannabidiol as an adjunctive therapy in schizophrenia. Other highlights: the relationship between age-related hearing loss and cognitive decline; how long-term SSRI treatment may delay progression from mild cognitive impairment to Alzheimer’s dementia; comparing computer-assisted cognitive-behavioral therapy (CBT) with standard CBT; and the value of exercise in early psychosis.
February 2018
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Executive Editor Michael Roy speaks with Margaret Sibley, Ph.D., about her article examining the diagnosis of late-onset ADHD. Other highlights: bright light therapy for bipolar depression; how well a single dose of ketamine reduced suicidal thoughts in patients with depression; a roadmap for understanding neurodevelopmental origins of conditions that manifest in early childhood; and prolonged postconcussive symptoms.
January 2018
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Editor-in-Chief Robert Freedman, M.D., discusses the 175th publication year of the Journal. Executive Editor Michael Roy reviews refugee mental health issues, exercise and the prevention of depression, cannabis use and risk of prescription opioid use disorder, and increased risk of smoking in female adolescents who had childhood ADHD.
December 2017
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This month, Executive Editor Michael Roy discusses brain function and psychotherapy outcomes in patients with PTSD, transgender research from a neurocognitive angle, research results of a new drug for schizophrenia, and characteristics of resilience in bipolar disorder and how individuals who are bipolar experience the world.
November 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses clinical genetic testing in psychiatry, binge drinking as a possible risk factor for alcohol use disorder, lithium versus divalproex for bipolar disorder in the elderly, the course of schizophrenia over the first 20 years, as well as trajectories of social functioning over 20 years.
October 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses the efficacy of psychodynamic therapy, the protective effect of pregnancy on the risk for drug abuse, the relation of ovarian hormone levels to symptoms in premenstrual dysphoric disorder, rates of mortality and self-harm in patients taking clozapine, and pharmacogenomic testing in psychiatry.
September 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses challenges in treating undocumented immigrants, long-term effects of antipsychotics in schizophrenia, whether substance use problems are associated with medications for ADHD, use of Social Security disability benefits by patients with first-episode psychosis receiving multifaceted specialty care, a large genome-wide association study of anorexia nervosa, and when and why medical students choose to specialize in psychiatry.
August 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses smartphones for self-management in schizophrenia, behavioral interventions in buprenorphine maintenance treatment, suicide following self-harm, effects of lithium and valproate on suicidal behavior in bipolar disorder, treatment of pediatric anxiety disorders with cognitive-behavioral-therapy (CBT) plus attention bias modification therapy, treatment of hypochondriasis with CBT plus medication, and treatment of major depression with amygdala neurofeedback.
July 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses psychiatric complications in primary parathyroidism with hypercalcemia, low-intensity transcranial current stimulation for psychiatric conditions, outcomes of vagus nerve stimulation for treatment-resistant depression, brain structure and function related to suicide attempts in young people with bipolar disorder, endogenous and medication-related risk for diabetes in schizophrenia, and gaze-contingent music reward therapy for social anxiety disorder.
June 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses patient preference and functional connectivity of the subcallosal cingulate cortex as possible predictors of treatment response in major depression, a behavioral phenotype of autism spectrum disorder characteristic of patients with known genetic abnormalities, functioning of the brain’s reward system in anorexia nervosa, collaboration between psychiatry and law enforcement, and a model of irritability in children and teens.
May 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses antidepressant efficacy for depression in children and adolescents, morbidity and mortality related to medications for depression, possible benefits of valbenazine for tardive dyskinesia, opioid detoxification using oral naltrexone versus buprenorphine, and the relation of divorce to the onset of alcohol use disorders.
April 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses the fetal origins of mental health, the effect of methylphenidate on the risk of manic episodes in bipolar disorder, contingency management for alcohol abuse in patients with serious mental illness, computerized cognitive training for older adults with mild cognitive impairment or dementia, prediction of relapse in Alzheimer’s disease patients after discontinuation of antipsychotic treatment, and the origins of cognitive deficits in people victimized during childhood.
March 2017
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This month, Executive Editor Michael Roy discusses collaboration between psychiatry and obstetrics, prescription opioid use disorder during pregnancy, integrated behavioral health homes, a possible relationship between Alzheimer’s disease and low hippocampal volume in late-life depression, switch rates during lithium and sertraline treatment of bipolar II depression, internet gaming disorder, and the relation of mental health to social networks following disaster.
February 2017
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This month, Executive Editor Michael Roy discusses use of stimulants and performance enhancers as a possible risk factor for PTSD, behavioral and brain markers of overgeneralized fear conditioning in PTSD, the epidemiology of first-episode psychosis, predictors of suicidal behavior, neural predictors of initiating alcohol use during adolescence, and mediation of placebo effects by patient expectancy in antidepressant clinical trials.
January 2017
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This month, Deputy Editor Susan K. Schultz, M.D., discusses the association of hypnotic medications and suicide, neurometabolic disorders in treatment-refractory depression, diminished attention to eyes in autism, increased activity or energy as a primary criterion for diagnosis of bipolar mania, an instrument for diagnosing premenstrual dysphoric disorder, and how to differentiate the effects of deep brain stimulation in Parkinson’s disease from the effects of the disease itself and psychiatric issues.
December 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses combat attachment behaviors in former service members with PTSD, postpartum psychosis, the association between pain and opioid use disorder, work productivity in relation to depression outcome, neural response to rewards as a predictor of depression, and adjustment disorder following trauma exposure.
November 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses practice and policies on perinatal substance abuse, relapse risk in patients with remitted depression, right unilateral ultrabrief-pulse ECT combined with medication in acute and maintenance geriatric depression, suicide risk calculated prospectively in a population cohort, and a new approach to fear and anxiety that takes into account both behavioral responses and conscious feeling states.
October 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses research on preventing firearm suicide, treatment guidelines for adult attention deficit hyperactivity disorder, long-term effects of supported employment for people with psychiatric disabilities, predicting psychosis risk in individuals with prodromal symptoms, how often psychotic experiences precede mental disorders and vice versa, and a 30-year follow-up study of offspring of depressed parents.
September 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses the diagnosis and treatment of trichotillomania, combining antidepressants with antipsychotics in schizophrenia, outcomes of the FDA reduction in the citalopram maximum dosage, heritable and nonheritable pathways to early callous and unemotional behaviors, and the effect of marriage on the risk for alcohol use disorder.
August 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses accelerometers in diagnosis and treatment of late-life depression, concomitant use of SSRIs and statins, treatment of cognitive impairment in schizophrenia with an alpha-7 nicotinic receptor agonist, the relation of adolescent marijuana use to subclinical psychotic symptoms and to mortality at age 60, and the effect of nicotine exposure during pregnancy to development of schizophrenia in offspring.
July 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses how psychiatrists can extend their role to treatment of general health conditions, how to evaluate randomized clinical trials, interpersonal psychotherapy for mental health problems, fluidity of symptoms in borderline personality disorder, predictors of bipolar illness in offspring of bipolar parents, and the relation of prenatal maternal distress to fetal behavior and to DNA changes in glucocorticoid-related genes in the placenta.
June 2016
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This month, Executive Editor Michael Roy discusses nutrient-based treatments as adjuncts to antidepressants, the prevalence and characteristics of cannabis use disorder as defined in DSM-5, long-term mortality rates in women with severe postpartum psychiatric disorders, a program for children in foster care and their biological parents designed to prevent repetition of childhood maltreatment, whether the relationship between preschool poverty and school-age depression is mediated by functional brain connectivity, and the NIMH Research Domain Criteria project.
May 2016
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This month, Executive Editor Michael Roy discusses a generalist model for treatment of borderline personality disorder, citalopram treatment for agitated patients with Alzheimer’s dementia, buprenorphine for severe suicidal ideation and as an adjunctive treatment in cases of antidepressant nonresponse, effects of prenatal choline supplementation on early-childhood behavior problems, and mechanisms of executive system dysfunction across psychiatric disorders in youths.
April 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses lurasidone for major depression with mixed features, bitemporal ECT compared with high-dose unilateral ECT given twice a week, neurocircuitry of depression with increased versus decreased appetite, attenuated psychosis syndrome, identification of distinct psychosis biotypes, and comprehensive community care for first-episode psychosis.
March 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses depression following stroke, cerebral abnormalities in patients with first-episode schizophrenia, risks of poorly monitored ketamine use for depression, long-term outcomes of light therapy versus CBT for seasonal affective disorder, the reproductive safety of second-generation antipsychotics, and the effects of antipsychotic review and nonpharmacological interventions on antipsychotic use, symptoms, and mortality in nursing home residents.
February 2016
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This month, Executive Editor Michael Roy discusses the risk of postpartum relapse in bipolar disorder and postpartum psychosis, the relation of pregnant women’s defense mechanisms to later behavior in their toddlers, sequential integration of pharmacotherapy and psychotherapy for depression, the dose-response relationship of SSRIs, the effectiveness of clozapine versus standard antipsychotic treatment for schizophrenia, and the relation of prenatal maternal depression, SSRIs, and benzodiazepines to infant neurobehavioral functioning.
January 2016
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This month, Deputy Editor Susan K. Schultz, M.D., discusses a request for abortion by a woman with major depression and psychosis, prescription opioid abuse and its treatment, questions about MRI findings of neuropathology underlying psychiatric illness, predicting response to antipsychotic drugs from baseline striatal functional connectivity, the association between obesity and ADHD, and amygdala hyperactivity during autobiographical recall as a possible trait marker of depression.
December 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses management of alcohol use disorder in patients requiring liver transplant, adding ziprasidone to escitalopram for treatment of depression, attention training for reducing PTSD symptoms, extended-release guanfacine for hyperactivity in autism spectrum disorder, a program for preventing anxiety disorders in offspring of anxious parents, and pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders.
November 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses psychiatric symptoms in Wilson’s disease, interactions between inflammation and depression, circulating miRNA levels in schizophrenia, the relation of smoking status to later schizophrenia, development of posttraumatic stress disorder in Army service members following traumatic brain injury, and working in the Amish culture.
October 2015
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This month, Executive Editor Michael Roy discusses ketamine and other NMDA antagonists as treatments for depression, a gene-environment interaction affecting depression risk, a longitudinal study of ADHD in children and adults, a follow-up of adolescents at clinical high risk of psychosis, and a clinical trial of citicoline for cocaine dependence in bipolar I disorder.
September 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses differential diagnosis of frontotemporal dementia, autoimmune encephalitis in postpartum psychosis, the role of oxytocin in borderline personality disorder, neural correlates of error processing in young people exposed to severe childhood abuse, light therapy versus cognitive-behavioral therapy for seasonal affective disorder, and cognitive enhancement treatment for people with mental illness who do not respond to supported employment.
August 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses the role of the psychiatrist in the collaborative care model, pharmacological management of Lewy body dementia, the relationship of depression subtype to antidepressant response, amygdala activity at rest in paranoid individuals with schizophrenia, and use of clonidine in opioid abstinence to prolong abstinence and decouple stress from craving in daily life.
July 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses diagnostic precursors of bipolar disorder in offspring of bipolar parents, intergenerational transmission of anxiety in the children of twins, separation anxiety disorder in children and adults, genetic and environmental influences on irritability from childhood to young adulthood, and the relation of impaired response inhibition to neural activation in adolescents with ADHD, their siblings, and healthy subjects.
June 2015
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This month, Executive Editor Michael Roy discusses psychiatric care during hepatitis C treatment with the new direct-acting antivirals, cognitive-behavioral therapy for anxiety disorders in adolescents, brain development over time in adolescents who are heavy drinkers, a genetic polymorphism related to early escalation of drinking and to impulsivity, how working memory is related to the ratio of serum levels of clozapine and its major metabolite, and a clinical trial testing the combination of citalopram and methylphenidate for geriatric depression.
May 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses narcissistic personality disorder, interpersonal psychotherapy for PTSD, brief cognitive-behavioral therapy to reduce suicide attempts in high-risk military personnel, effects on children of their mothers’ response to antidepressant medication, and the relation of autistic traits to neuroanatomy in the general population.
April 2015
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This month, Deputy Editor Susan Schultz discusses an innovative study that used an algorithm to search electronic health records for clinical information relevant to the Research Domain Criteria; potentially modifiable conditions that predict a transition from mild cognitive impairment to dementia; a trial of cognitive-bias modification to reduce reactivity to alcohol cues in patients with alcohol dependence; a clinical trial that added health coaching to fitness club membership for overweight persons with serious mental illness; and an intriguing short essay about correspondence between Charles Darwin and the head gardener at an English mental institution.
March 2015
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This month, Executive Editor Michael Roy discusses adjustment disorder in a health care worker with Ebola, a case of psychotic symptoms that improved with a gluten-free diet, medication prescribing for first-episode schizophrenia, outcomes for young people at ultra-high risk for psychosis who do not transition to psychotic disorders, possible mechanisms in perimenopausal depression, and change during adolescence in reactivity of the amygdala in relation to stressful life events and family history of depression.
February 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses treatment for postpartum psychosis and mania, a home-visiting intervention for pregnant teenage American Indian mothers, brain patterns underlying learning deficits in autism spectrum disorders, an approach to the genetics of schizophrenia focusing on clusters of genetic variants and clusters of clinical features, and effects of the Affordable Care Act’s expansion of insurance for young adults on rates of hospital admissions and emergency department visits.
January 2015
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This month, Deputy Editor Susan K. Schultz, M.D., discusses hypercalcemia and hyperparathyroidism during lithium therapy, a weight loss intervention tailored to individuals taking antipsychotic medications, the effect of socioeconomic disadvantage on outcome of collaborative depression care in OB-GYN clinics, ECT for treatment-resistant bipolar depression, ECT for clozapine-resistant schizophrenia, and the relation of an intervention for kindergartners with chronic conduct problems to psychopathology and crime at age 25.