American Journal of Psychiatry
- Volume 167
- Number 7
- July 2010
In This Issue
Editorial
Commentary
Introspections
Clinical Case Conference
Images in Psychiatry
Reviews and Overviews
D2 Receptor Genetic Variation and Clinical Response to Antipsychotic Drug Treatment: A Meta-Analysis
Publication date: 01 July 2010
Pages763–772ObjectiveSeveral lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D2) receptor blockade. Therefore, it seems plausible that variation in the DRD2 gene is associated with clinical response to antipsychotic drug ...
https://doi.org/10.1176/appi.ajp.2009.09040598Article
Publication date: 01 July 2010
Pages773–781ObjectiveThe authors examined the prevalence and distribution of mental disorders in rural Chinese 15–34 years of age who committed suicide. They hypothesized that mental illness is a risk factor for suicide in this population and that the prevalence of ...
https://doi.org/10.1176/appi.ajp.2010.09101476Publication date: 01 July 2010
Pages782–791ObjectiveThe purpose of this study was to report on the outcome of participants in the Treatment of Resistant Depression in Adolescents (TORDIA) trial after 24 weeks of treatment, including remission and relapse rates and predictors of treatment outcome. ...
https://doi.org/10.1176/appi.ajp.2010.09040552Publication date: 01 July 2010
Pages792–800ObjectiveThe authors examined the safety and efficacy of long-term fluoxetine monotherapy, lithium monotherapy, and placebo therapy in preventing relapse and recurrence of bipolar type II major depressive episode. The authors hypothesized that fluoxetine ...
https://doi.org/10.1176/appi.ajp.2009.09020284Publication date: 01 July 2010
Pages801–808ObjectiveProspective long-term studies of risk factors for suicide attempts among patients with major depressive disorder have not investigated the course of illness and state at the time of the act. Therefore, the importance of state factors, ...
https://doi.org/10.1176/appi.ajp.2010.09050627Publication date: 01 July 2010
Pages809–817ObjectiveChildren with autism spectrum disorders often experience severe anxiety and depression, yet the explanation for this association remains unclear. The authors examined the longitudinal relationship between autistic-like and internalizing traits ...
https://doi.org/10.1176/appi.ajp.2009.09070990Publication date: 01 July 2010
Pages818–827ObjectiveSchizophrenia is characterized by widespread cognitive deficits that reflect distributed dysfunction across multiple cortical regions. Here the authors examined the relationship between lower- and higher-level dysfunction within the auditory ...
https://doi.org/10.1176/appi.ajp.2010.09030338Publication date: 01 July 2010
Pages828–835ObjectiveA recent meta-analysis identified processing speed inefficiency as the largest single cognitive impairment in schizophrenia. However, the effect of potential moderator variables, such as medication status and severity of illness, remained ...
https://doi.org/10.1176/appi.ajp.2010.09070937Publication date: 01 July 2010
Pages836–844ObjectiveDysfunction of the hippocampus has long been suspected to be a key component of the pathophysiology of major depressive disorder. Despite evidence of hippocampal structural abnormalities in depressed patients, abnormal hippocampal functioning has ...
https://doi.org/10.1176/appi.ajp.2009.09050614Publication date: 01 July 2010
Pages845–853ObjectiveThe view that everyday function is preserved in mild cognitive impairment may be problematic. The objectives of this study were to determine the magnitude of impairment in everyday function in patients with mild cognitive impairment and Alzheimer'...
https://doi.org/10.1176/appi.ajp.2010.09050692Publication date: 01 July 2010
Pages854–865ObjectiveThe Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N=3,364) and African American (N=1,301) subjects. MethodSubjects gave consent to deposit phenotypic data and blood samples ...
https://doi.org/10.1176/appi.ajp.2010.09071050Letter to the Editor
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