American Journal of Psychiatry

Skin picking consumes hours a day for some individuals, causing disfigurement and interfering with social or work life. Skin picking disorder has a prevalence of 1%–5% and can arise at any age, often after the onset of a dermatological condition. Although ...

https://doi.org/10.1176/appi.ajp.2012.12040508

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Perspectives

Reviews and Overviews

Synaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine

Publication date: 01 November 2012

Pages1150–1156

Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major depressive disorder, ...

https://doi.org/10.1176/appi.ajp.2012.12040531

New Research

Articles

Psychiatric Disorders in Preschoolers: Continuity From Ages 3 to 6

Publication date: 01 November 2012

Pages1157–1164

About half of 127 children meeting criteria for psychiatric diagnoses at age 3 received diagnoses again at age 6, and half of those with psychiatric diagnoses at age 6 also had disorders at age 3. Disorders most likely to remain constant were ADHD, ...

https://doi.org/10.1176/appi.ajp.2012.12020268

Neurodevelopment of Children Following Prenatal Exposure to Venlafaxine, Selective Serotonin Reuptake Inhibitors, or Untreated Maternal Depression

Publication date: 01 November 2012

Pages1165–1174

An examination of children of depressed mothers at age 3–6 found that IQs are lower in these children than in children of nondepressed mothers, and behavioral problems are somewhat more common. However, neither difference was related to prenatal ...

https://doi.org/10.1176/appi.ajp.2012.11111721

Psychopathology in Adolescent Offspring of Parents With Panic Disorder, Major Depression, or Both: A 10-Year Follow-Up

Publication date: 01 November 2012

Pages1175–1184

Objective The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder. Method The authors examined rates of psychiatric ...

https://doi.org/10.1176/appi.ajp.2012.11101514

Treatment Course With Antidepressant Therapy in Late-Life Depression

Publication date: 01 November 2012

Pages1185–1193

Objective In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg ...

https://doi.org/10.1176/appi.ajp.2012.12010122

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

Publication date: 01 November 2012

Pages1194–1202

Objective The subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of brain-derived neurotrophic factor (BDNF) and reduced markers for GABA function, including in the amygdala, ...

https://doi.org/10.1176/appi.ajp.2012.12020248

Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia

Publication date: 01 November 2012

Pages1203–1210

Objective Elevated presynaptic striatal dopaminergic function is a robust feature of schizophrenia. However, the relationship between this dopamine abnormality and the response to dopamine-blocking antipsychotic treatments is unclear. The authors tested ...

https://doi.org/10.1176/appi.ajp.2012.12010144