American Journal of Psychiatry

The authors review abnormal thyroid function test results for psychiatric patients, who are often screened routinely. Although primary thyroid abnormalities can have significant psychiatric symptoms, most of the abnormalities detected are asymptomatic, ...

https://doi.org/10.1176/appi.ajp.2011.11040631

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Perspectives

Reviews and Overviews

Persistent Pulmonary Hypertension of the Newborn and Selective Serotonin Reuptake Inhibitors: Lessons From Clinical and Translational Studies

Publication date: 01 February 2012

Pages134–140

The authors review the incidence of persistent pulmonary hypertension in newborns of women treated with SSRIs. Three of six studies showed elevated risk, but all failed to control fully for the possible effects of depression itself, including shorter ...

https://doi.org/10.1176/appi.ajp.2011.11040553

New Research

Articles

Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis

Publication date: 01 February 2012

Pages141–151

Objectives:Evidence suggests that childhood maltreatment may negatively affect not only the lifetime risk of depression but also clinically relevant measures of depression, such as course of illness and treatment outcome. The authors conducted the first ...

https://doi.org/10.1176/appi.ajp.2011.11020335

Ventral Striatum Response During Reward and Punishment Reversal Learning in Unmedicated Major Depressive Disorder

Publication date: 01 February 2012

Pages152–159

Objective:Affective biases may underlie many of the key symptoms of major depressive disorder, from anhedonia to altered cognitive performance. Understanding the cause of these biases is therefore critical in the quest for improved treatments. Depression ...

https://doi.org/10.1176/appi.ajp.2011.11010137

Stimulant Medication Use in Children: A 12-Year Perspective

Publication date: 01 February 2012

Pages160–166

Objective:The authors examined the utilization of stimulant medications for the treatment of ADHD in U.S. children during the period 1996–2008 to determine trends by age, sex, race/ethnicity, family income, and geographic region. Method:The 1996–2008 ...

https://doi.org/10.1176/appi.ajp.2011.11030387

Blood Pressure and Heart Rate Over 10 Years in the Multimodal Treatment Study of Children With ADHD

Publication date: 01 February 2012

Pages167–177

Objective:It is unknown whether prolonged childhood exposure to stimulant medication for the treatment of attention deficit hyperactivity disorder (ADHD) increases the risk for developing abnormalities in blood pressure or heart rate. The authors examined ...

https://doi.org/10.1176/appi.ajp.2011.10111705

Methylphenidate and Risk of Serious Cardiovascular Events in Adults

Publication date: 01 February 2012

Pages178–185

Methylphenidate treatment of ADHD in adults was associated with an increase in sudden death from ventricular arrhythmia, from 1 death per 1,000 person-years to 2 deaths. The effect was more marked at lower rather than higher doses, suggesting that lower ...

https://doi.org/10.1176/appi.ajp.2011.11010125

Investigating the Contribution of Common Genetic Variants to the Risk and Pathogenesis of ADHD

Publication date: 01 February 2012

Pages186–194

Objective:A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (...

https://doi.org/10.1176/appi.ajp.2011.11040551

Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3

Publication date: 01 February 2012

Pages195–204

Objective:Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings ...

https://doi.org/10.1176/appi.ajp.2011.11060822

Striatal Functional Alteration During Incentive Anticipation in Pediatric Anxiety Disorders

Publication date: 01 February 2012

Pages205–212

Objective:Behavioral inhibition is an early childhood temperament recently associated with altered striatal response in adolescence to incentives of increasing magnitudes. Since early childhood behavioral inhibition is also associated with risk for ...

https://doi.org/10.1176/appi.ajp.2011.11010006

Attention Bias Modification Treatment for Pediatric Anxiety Disorders: A Randomized Controlled Trial

Publication date: 01 February 2012

Pages213–230

Objective:While attention bias modification (ABM) is a promising novel treatment for anxiety disorders, clinical trial data remain restricted to adults. The authors examined whether ABM induces greater reductions in pediatric anxiety symptoms and symptom ...

https://doi.org/10.1176/appi.ajp.2011.11060886